The fetal origins of coronary heart disease

Barker, Djp

doi:10.1111/j.1651-2227.1997.tb18351.x

Cited by 515 publications

(550 citation statements)

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“…In 1989, Barker exposed the relationship between birth weight and the lifetime risk for CHD. He showed that the lower the weight of the newborn and during infancy, the higher the risk for CHD in later life, a fact that has been demonstrated in many subsequent studies (15)(16)(17) . The relationship between birth weight and later obesity has been less studied and there is insufficient evidence.…”

mentioning

confidence: 78%

Birth weight and obesity risk at first grade of high school in a non-concurrent cohort of Chilean children

Loaiza

Atalah

2012

Public Health Nutr.

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Objective: To determine the association of birth weight with obesity risk at first grade of high school in Chilean children after accounting for potential confounding factors. Design: National non-concurrent cohort of newborns. Sociodemographic information, height, weight and anthropometric measurements at first grade of high school were analysed. Birth weight was classified as macrosomia ($4000 g), by gestational age and by ponderal index. The relationship between birth weight and obesity at first grade of high school (BMI $ 95th percentile of the US Centers for Disease Control and Prevention's reference) was assessed using logistic regression models adjusted for sociodemographic information at delivery. Setting: First grade of public high school of low and middle socio-economic status in the whole country (about 77 % of Chilean children in this age group). Subjects: Newborns (n 119 070) and the same number of high-school students. Results: A positive relationship of high ponderal index (OR 5 1?86, 95 % CI 1?69, 2?03), birth weight $4000 g (OR 5 1?66, 95 % CI 1?54, 1?78) and large for gestational age (OR 5 1?69, 95 % CI 1?58, 1?81) with obesity at adolescence (P , 0?001) was found. Macrosomic children had a higher risk of being obese at first grade of high school after controlling for prenatal confounding variables (OR 5 1?63, 95 % CI 1?52, 1?76; P , 0?001). Conclusions: A direct relationship between high birth weight and obesity at first grade of high school was observed in this group of Chilean children. The results highlight the significance of birth weight as a simple tool to be used as an indicator of obesity risk for children by health-care providers.

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confidence: 78%

Birth weight and obesity risk at first grade of high school in a non-concurrent cohort of Chilean children

Loaiza

Atalah

2012

Public Health Nutr.

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“…A strand of recent work suggests that nutrition in utero can affect health status in middle age, through its impact on such important chronic conditions as coronary heart disease and diabetes (Barker, 1995;Ravelli et al, 1998). New experimental work finds that mice whose fetal growth is restricted, but who are fed well after birth, exhibit rapid catch-up growth but die significantly earlier than mice well fed in utero (Ozanne and Hales, 2004).…”

Section: Introductionmentioning

confidence: 99%

The lasting impact of childhood health and circumstance

Case

Fertig

Paxson

2005

Journal of Health Economics

1,341

1,054

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We quantify the lasting effects of childhood health and economic circumstances on adult health, employment and socioeconomic status, using data from a birth cohort that has been followed from birth into middle age. Controlling for parental income, education and social class, children who experience poor health have significantly lower educational attainment, poorer health, and lower social status as adults. Childhood health and circumstance appear to operate both through their impact on initial adult health and economic status, and through a continuing direct effect of prenatal and childhood health in middle age. Overall, our findings suggest more attention be paid to health as a potential mechanism through which intergenerational transmission of economic status takes place: cohort members born into poorer families experienced poorer childhood health, lower investments in human capital and poorer health in early adulthood, all of which are associated with lower earnings in middle age-the years in which they themselves become parents.

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“…The notion that exposure to risk factors in early life in utero or in childhood may causally affect health later in life was first empirically investigated by Barker in relation to the metabolic syndrome, type II diabetes and cardiovascular diseases. Barker suggested that the last trimester of life in utero was a "critical period" which if exposed to growth retardation would eventually result in a number of increased risk factors and diseases related to the metabolic syndrome (Barker, 1995;Barker, 1998). The critical period hypothesis has later been empirically investigated with regard to a variety of diseases other than the metabolic syndrome and its clinical consequences (Sahade et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Economic stress in childhood and adulthood, and poor psychological health: Three life course hypotheses

Lindström

Fridh

2014

Psychiatry Research

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Link to publication Citation for published version (APA): Lindström, M., Fridh, M., & Rosvall, M. (2014). Economic stress in childhood and adulthood, and poor psychological health: Three life course hypotheses. Psychiatry Research, 215(2), 386-393. DOI: 10.1016/j.psychres.2013 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Logistic regression models were used to investigate the associations adjusting for age, country of birth, socioeconomic status, emotional support, instrumental support and trust, and stratifying by sex. The accumulation hypothesis was confirmed because combined childhood and adulthood exposures to economic stress were associated with poor psychological health in a graded manner. The social mobility hypothesis was also confirmed. The critical period hypothesis was not confirmed because both childhood and adulthood economic stress remained significantly associated with poor psychological health in adulthood. Economic stress in childhood is associated with mental health in adulthood.

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The fetal origins of coronary heart disease

Cited by 515 publications

References 30 publications

Birth weight and obesity risk at first grade of high school in a non-concurrent cohort of Chilean children

Birth weight and obesity risk at first grade of high school in a non-concurrent cohort of Chilean children

The lasting impact of childhood health and circumstance

Economic stress in childhood and adulthood, and poor psychological health: Three life course hypotheses

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