2022
DOI: 10.1055/s-0042-1756194
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The Fibrinolytic System in Peripartum Depression

Abstract: The relationship between depression and reduced fibrinolytic activity reflects the role of tissue plasminogen activator and plasmin in brain remodeling underlying resilience, depression remission, and reward processing, rather than the dissolution of fibrin clots. Individuals who experience depression demonstrate hippocampal and prefrontal cortex atrophy, as well as impaired neuronal connectivity. Brain-derived neurotrophic factor (BDNF), synthesized as a precursor that is activated through cleavage by tissue … Show more

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“…The role of the fibrinolytic system in maternal peripartum depression is described by Hoirisch-Clapauch. 8 Both tissue plasminogen activator and plasmin are involved in brain remodeling underlying resilience, depression remission, and reward processing rather than dissolution of fibrin clots. The article depicts the fibrinolytic status in the healthy brain, in stress, and depression and discusses a potential association between hypo-fibrinolysis and peripartum depression.…”
mentioning
confidence: 99%
“…The role of the fibrinolytic system in maternal peripartum depression is described by Hoirisch-Clapauch. 8 Both tissue plasminogen activator and plasmin are involved in brain remodeling underlying resilience, depression remission, and reward processing rather than dissolution of fibrin clots. The article depicts the fibrinolytic status in the healthy brain, in stress, and depression and discusses a potential association between hypo-fibrinolysis and peripartum depression.…”
mentioning
confidence: 99%