Abstract:Objectives: We tested the ability of the VASFIQ, a seven-item scale composed of Fibromyalgia Impact Questionnaire (FIQ) visual analog scales (VASs), to quantify fibromyalgia global disease severity and identify fibromyalgia patients with significant symptoms of fatigue, poor sleep, depression or anxiety. . Patient scores used in the analyses were derived from 2229 patients enrolled in three pregabalin fibromyalgia trials. Receiver operating characteristic analyses determined VASFIQ cutoff scores identifying patients with clinically significant symptom levels using full-length, validated symptom questionnaires to define cases. Results: Global VASFIQ and FIQ scores correlated highly at baseline and study endpoints (r ¼ 0.94 and 0.97, respectively; both p < 0.0001). Change in global VASFIQ and FIQ scores correlated similarly to PGIC scores at study endpoints (r ¼ 0.58 and 0.61, respectively; both p < 0.0001). Individual FIQ VAS scores correlated with corresponding full-length symptom questionnaire scores at baseline and study endpoints (VASfatigue with MAF-GFI, r ¼ 0.64 and 0.76; VASsleep with SPI, r ¼ 0.50 and 0.67; VASdepression with HADS-D, r ¼ 0.43 and 0.62; VASanxiety with HADS-A, r ¼ 0.47 and 0.67, respectively; p < 0.0001 for all). Patients with significant symptoms of fatigue were identified by VASfatigue >7.5, poor sleep by VASsleep >7.9, depression by VASdepression >5.8 and anxiety by VASanxiety >6.0. VASFIQ global scores 31.4 and 45.0 identified patients with moderate and severe global fibromyalgia symptoms, respectively. Conclusions: The VASFIQ scale accurately quantifies global fibromyalgia severity and identifies patients with significant symptoms of fatigue, poor sleep, depression or anxiety with brevity, enabling rapid patient assessment and informing treatment decisions in busy clinics.