The “field or frequency” dilemma in magnetic hyperthermia: The case of Zn Mn ferrite nanoparticles

Liu, N.N.; Pyatakov, A. P.; Saletsky, A. M.; Zharkov, Mikhail N.; Pyataev, N. A.; Sukhorukov, Gleb B.; Gun’ko, Yurii K.; Tishin, A.M.

doi:10.1016/j.jmmm.2022.169379

Cited by 19 publications

(20 citation statements)

References 27 publications

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“…These parameters fulfill the Atkinson–Brezovich criteria, making them essential factors. For potential biological, clinical, and tumor therapy applications, 50–2000 kHz frequencies are recommended to avoid excessive skeletal muscle stimulation. , Additionally, the product of magnetic field intensity and frequency should not exceed 4.85 × 10 9 A m –1 s –1 . − The combinations of frequencies and magnetic field intensities used for the drug release experiments fell within the previously proposed values (3.3 × 10 9 A m –1 s –1 ), suggesting the potential applications of the ternary systems for in vivo studies and physiological conditions.…”

Section: Resultsmentioning

confidence: 99%

Controlled Release of the Anticancer Drug Cyclophosphamide from a Superparamagnetic β-Cyclodextrin Nanosponge by Local Hyperthermia Generated by an Alternating Magnetic Field

Salazar Sandoval,

Díaz-Saldívar,

Araya

et al. 2024

ACS Appl. Mater. Interfaces

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A β-cyclodextrin (β-CD) nanosponge (NS) was synthesized using diphenyl carbonate (DPC) as a cross-linker to encapsulate the antitumor drug cyclophosphamide (CYC), thus obtaining the NSs-CYC system. The formulation was then associated with magnetite nanoparticles (MNPs) to develop the MNPs-NSs-CYC ternary system. The formulations mentioned above were characterized to confirm the deposition of the MNPs onto the organic matrix and that the superparamagnetic nature of the MNPs was preserved upon association. The association of the MNPs with the NSs-drug complex was confirmed through field emission scanning electron microscopy, energy dispersive spectroscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, dynamic light scattering, ζ-potential, atomic absorption spectroscopy, X-ray powder diffraction, selected area electron diffraction, and vibrating-sample magnetometer. The superparamagnetic properties of the ternary system allowed the release of CYC by utilizing magnetic hyperthermia upon the exposure of an alternating magnetic field (AMF). The drug release experiments were carried out at different frequencies and intensities of the magnetic field, complying with the "Atkinson−Brezovich criterion". The assays in AMF showed the feasibility of release by controlling hyperthermia of the drug, finding that the most efficient conditions were F = 280 kHz, H = 15 mT, and a concentration of MNPs of 5 mg/mL. CYC release was temperature-dependent, facilitated by local heat generation through magnetic hyperthermia. This phenomenon was confirmed by DFT calculations. Furthermore, the ternary systems outperformed the formulations without MNPs regarding the amount of released drug. The MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assays demonstrated that including CYC within the magnetic NS cavities reduced the effects on mitochondrial activity compared to those observed with the free drug. Finally, the magnetic hyperthermia assays showed that the tertiary system allows the generation of apoptosis in HeLa cells, demonstrating that the MNPs embedded maintain their properties to generate hyperthermia. These results suggest that using NSs associated with MNPs could be a potential tool for a controlled drug delivery in tumor therapy since the materials are efficient and potentially nontoxic.

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Section: Resultsmentioning

confidence: 99%

Controlled Release of the Anticancer Drug Cyclophosphamide from a Superparamagnetic β-Cyclodextrin Nanosponge by Local Hyperthermia Generated by an Alternating Magnetic Field

Salazar Sandoval,

Díaz-Saldívar,

Araya

et al. 2024

ACS Appl. Mater. Interfaces

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“…Several other types of magnetic nanoparticles have also been utilized in magnetic hyperthermia including iron, 46 magnesium alloys, 79 Ni alloys, 80 Ni-Cr alloy, 81 Ni-Si and Ni-Al, 82 Fe-Ni alloys, 83 Fe-Co alloy, 47 FeNiCo alloys, 84 Ni-Cu alloys, 85,86 Fe-Al alloy, 87 Fe-Au alloys, 88,89 Fe 3 C nanoparticles, 71 Fe-Cr-Nb-B alloy, 90 Fe-Mn-Gd ferrite, 91 hematite (α-Fe 2 O 3 ) and nickel ferrite, 92 cobalt ferrite, [93][94][95][96][97][98][99][100][101][102][103][104][105] cobalt zinc ferrite, [106][107][108][109][110][111] Zn-Mg ferrite, 112 Mg 0.7 Zn 0.3 Fe 2 O 4 nanocrystals, 113 manganese ferrite , 44,[114][115][116][117][118] ZnMn ferrite, [119][120][121][122]…”

Section: Copper Ferritementioning

confidence: 99%

“…Several other types of magnetic nanoparticles have also been utilized in magnetic hyperthermia including iron, 46 magnesium alloys, 79 Ni alloys, 80 Ni-Cr alloy, 81 Ni-Si and Ni-Al, 82 Fe-Ni alloys, 83 Fe-Co alloy, 47 FeNiCo alloys, 84 Ni-Cu alloys, 85,86 Fe-Al alloy, 87 Fe-Au alloys, 88,89 Fe 3 C nanoparticles, 71 Fe-Cr-Nb-B alloy, 90 Fe–Mn–Gd ferrite, 91 hematite (α-Fe 2 O 3 ) and nickel ferrite, 92 cobalt ferrite, 93–105 cobalt zinc ferrite, 106–111 Zn‐Mg ferrite, 112 Mg 0.7 Zn 0.3 Fe 2 O 4 nanocrystals, 113 manganese ferrite , 44,114–118 ZnMn ferrite, 119–124 magnesium ferrite, 125–128 zinc ferrite, 45,129–133 Zn–Ni spinel ferrite, 134 Zn-doped spinel Fe 3 O 4 , 135 nickel ferrite, 136 copper ferrite, 137 copper zinc ferrite, 138 and γ-Fe 2 O 3 . 139–144…”

Section: Nanoparticles Used In Magnetic Hyperthermiamentioning

confidence: 99%

Magnetic hyperthermia in cancer therapy, mechanisms, and recent advances: A review

Molaei

2024

J Biomater Appl

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Hyperthermia therapy refers to the elevating of a region in the body for therapeutic purposes. Different techniques have been applied for hyperthermia therapy including laser, microwave, radiofrequency, ultrasonic, and magnetic nanoparticles and the latter have received great attention in recent years. Magnetic hyperthermia in cancer therapy aims to increase the temperature of the body tissue by locally delivering heat from the magnetic nanoparticles to cancer cells with the aid of an external alternating magnetic field to kill the cancerous cells or prevent their further growth. This review introduces magnetic hyperthermia with magnetic nanoparticles. It includes the mechanism of the operation and magnetism behind the magnetic hyperthermia phenomenon. Different synthesis methods and surface modification to enhance the biocompatibility, water solubility, and stability of the nanoparticles in physiological environments have been discussed. Recent research on versatile types of magnetic nanoparticles with their ability to increase the local temperature has been addressed.

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“…The replacement of ferrous iron in magnetite and the formation of a mixed oxide makes it possible to change the properties of MNPs, for example, magnetic (Co, Ni) or antibacterial (Zn, Cu). The MHT agents can be ferrites such as Co-Fe, Ni-Fe [67], and Ca-Mn [68], Zn-Mn [69], Cu-Co [70], Co-Mn [45] mixed ferrites.…”

Section: Types Of Mnps Suitable For Ht and Their Requirementsmentioning

confidence: 99%

Metal and Metal Oxides Nanoparticles and Nanosystems in Anticancer and Antiviral Theragnostic Agents

et al. 2023

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The development of antiviral treatment and anticancer theragnostic agents in recent decades has been associated with nanotechnologies, and primarily with inorganic nanoparticles (INPs) of metal and metal oxides. The large specific surface area and its high activity make it easy to functionalize INPs with various coatings (to increase their stability and reduce toxicity), specific agents (allowing retention of INPs in the affected organ or tissue), and drug molecules (for antitumor and antiviral therapy). The ability of magnetic nanoparticles (MNPs) of iron oxides and ferrites to enhance proton relaxation in specific tissues and serve as magnetic resonance imaging contrast agents is one of the most promising applications of nanomedicine. Activation of MNPs during hyperthermia by an external alternating magnetic field is a promising method for targeted cancer therapy. As therapeutic tools, INPs are promising carriers for targeted delivery of pharmaceuticals (either anticancer or antiviral) via magnetic drug targeting (in case of MNPs), passive or active (by attaching high affinity ligands) targeting. The plasmonic properties of Au nanoparticles (NPs) and their application for plasmonic photothermal and photodynamic therapies have been extensively explored recently in tumor treatment. The Ag NPs alone and in combination with antiviral medicines reveal new possibilities in antiviral therapy. The prospects and possibilities of INPs in relation to magnetic hyperthermia, plasmonic photothermal and photodynamic therapies, magnetic resonance imaging, targeted delivery in the framework of antitumor theragnostic and antiviral therapy are presented in this review.

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The “field or frequency” dilemma in magnetic hyperthermia: The case of Zn Mn ferrite nanoparticles

Cited by 19 publications

References 27 publications

Controlled Release of the Anticancer Drug Cyclophosphamide from a Superparamagnetic β-Cyclodextrin Nanosponge by Local Hyperthermia Generated by an Alternating Magnetic Field

Controlled Release of the Anticancer Drug Cyclophosphamide from a Superparamagnetic β-Cyclodextrin Nanosponge by Local Hyperthermia Generated by an Alternating Magnetic Field

Magnetic hyperthermia in cancer therapy, mechanisms, and recent advances: A review

Metal and Metal Oxides Nanoparticles and Nanosystems in Anticancer and Antiviral Theragnostic Agents

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