The fight against multidrug-resistant organisms: The role of ZnO crystalline defects

Lucas-Gil, Eva de; Campo, Adolfo del; Pascual, L.; Monte-Serrano, Mercedes; Menéndez, J.Á.; Fernández, J.F.; Rubio-Marcos, Fernando

doi:10.1016/j.msec.2019.02.004

Cited by 22 publications

(26 citation statements)

References 43 publications

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“…Specifically, Figure S2d (Supplementary Materials) allows observing clearly and unequivocally the nanometric character of the obtained ZnO. A close study of a particle is shown in Figure S2e It should be noted that recently we have been evidenced an excellent antimicrobial response of the nanoparticulated ZnO against multidrug-resistant organisms (MDROs), which strongly depends on the crystalline defects of ZnO [30]. In the next section, we go a step further and will demonstrate that the high antimicrobial activity can be used for the development of an inorganic composite as a paint preservative for antifungal applications…”

Section: Initial Premises: High Antimicrobial Response Of the Nanoparmentioning

confidence: 84%

“…The choice of modified bentonite clay with Ag cations, hereafter Clay, is due to the well-known antibacterial properties of Ag [31,32]. Even, previous studies show the good antibacterial activity of this modified clay against different types of bacteria [30,33]. Therefore, it is mandatory to complement the antibacterial activity of Ag cation with a preservative against fungi such as ZnO.…”

Section: Finding a Potential Technological Application Of The Zno/clamentioning

confidence: 99%

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The Benefits of the ZnO/Clay Composite Formation as a Promising Antifungal Coating for Paint Applications

Lucas-Gil

Menéndez²,

Pascual

et al. 2020

Applied Sciences

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Featured Application: Herein, we provide an inorganic composite as a paint preservative for antifungal applications. From a paint commercial additive, we add synthesized ZnO nanoparticles in order to improve the antimicrobial response. The main aim of this study is to generate a cost-efficient, eco-friendly material, without human health risk. We have developed a method for the controlled dispersion of ZnO nanoparticles on paint additive through a cooperative assembly-directed process at room temperature. The antifungal response of the inorganic composite is tested against the common fungi, Aspergillus niger. In this work we take a step further, studying the composite developed in a paint application. We believe that this paper can serve as a turning point in the search of alternative preservatives against fungi in different environments from industrial to hospital. Abstract:The presence of mold is a serious problem in different environments as industrial, agricultural, hospital and household, especially for human health. Large quantities of mold spores can potentially cause allergic reactions and respiratory problems. Therefore, it is essential to keep buildings free of fungi without harming human health and the environment. Here, we pose a composite of modified bentonite clay and ZnO nanoparticles as an alternative antifungal preservative. The new composite is obtained by an easy and eco-friendly method based on a dry nanodispersion, without altering the properties of each material. The antifungal test reveals a robust response against fungi thanks to the ZnO nanoparticles' contribution. Our results reveal that the antifungal activity of ZnO/clay composite is governed by both a uniform distribution and an adequate concentration of the ZnO nanoparticles onto the clay surface. Specifically, we find that for concentration below 10 wt.% of the ZnO nanoparticles, the nanoparticles are well dispersed onto clay giving rise to an excellent antifungal response. By contrast, when the concentration of ZnO increases, the formation of ZnO agglomerates onto the clay surface is favored. This effect provokes that antifungal behavior changes towards a more moderate improvement. Finally, we have demonstrated that this composite can be used as a promising paint preservative for antifungal applications.

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Section: Initial Premises: High Antimicrobial Response Of the Nanoparmentioning

confidence: 84%

Section: Finding a Potential Technological Application Of The Zno/clamentioning

confidence: 99%

The Benefits of the ZnO/Clay Composite Formation as a Promising Antifungal Coating for Paint Applications

Lucas-Gil

Menéndez²,

Pascual

et al. 2020

Applied Sciences

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“…ZnO is a potential antibacterial agent due to its flexibility and broad spectrum of action against microbes [ 20 , 21 ]. Based on the electric charges stored in the Schottky barriers, it was recently revealed that nanostructured ZnO microparticles have outstanding antibacterial characteristics [ 20 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Novel 1,2,3-Triazole-sulphadiazine-ZnO Hybrids as Potent Antimicrobial Agents against Carbapenem Resistant Bacteria

et al. 2022

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Bacterial pneumonia is considered one of the most virulent diseases with high morbidity and mortality rates, especially in hospitalized patients. Moreover, bacterial resistance increased over the last decades which limited the therapy options to carbapenem antibiotics. Hence, the metallo-β-lactamase-producing bacteria were deliberated as the most deadly and ferocious infectious agents. Sulphadiazine-ZnO hybrids biological activity was explored in vitro and in vivo against metallo-β-lactamases (MBLs) producing Klebsiella pneumoniae. Docking studies against NDM-1 and IMP-1 MBLs revealed the superior activity of the 3a compound in inhibiting both MBLs enzymes in a valid reliable docking approach. The MBLs inhibition enzyme assay revealed the remarkable sulphadiazine-ZnO hybrids inhibitory effect against NDM-1 and IMP-1 MBLs. The tested compounds inhibited the enzymes both competitively and noncompetitively. Compound 3b-ZnO showed the highest antibacterial activity against the tested metallo-β-lactamase producers with an inhibition zone (IZ) diameter reaching 43 mm and a minimum inhibitory concentration (MIC) reaching 2 µg/mL. Sulphadiazine-ZnO hybrids were tested for their in vitro cytotoxicity in a normal lung cell line (BEAS-2Bs cell line). Higher cell viability was observed with 3b-ZnO. Biodistribution of the sulphadiazine-ZnO hybrids in the lungs of uninfected rats revealed that both [124I]3a-ZnO and [124I]3b-ZnO hybrids remained detectable within the rats’ lungs after 24 h of endotracheal aerosolization. Moreover, the residence duration in the lungs of [124I]3b-ZnO (t1/2 4.91 h) was 85.3%. The histopathological investigations confirmed that compound 3b-ZnO has significant activity in controlling bacterial pneumonia infection in rats.

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“…The coupling of two different semiconductors can yield an efficient charge separation, leading to a vector transmission of photogenerated electrons and holes from one semiconductor material to the other [7][8][9][10]. ZnO is a semiconductor material with a wide direct bandgap of 3.2 eV, which can absorb a small part of the solar spectrum in the UV region [11][12][13]. CuO is a nontoxic, chemically stable and naturally abundant material.…”

Section: Introductionmentioning

confidence: 99%

Preparation, characterization and photocatalytic performance of heterostructured CuO–ZnO-loaded composite nanofiber membranes

Fang¹,

Liang²,

Xu³

2020

Beilstein J. Nanotechnol.

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Inorganic semiconductor oxides loaded on composite nanofibers (CNFs) have been widely applied in environmental monitoring, industry, aviation, and transportation. In this paper, heterostructured CuO-ZnO-loaded CNF membranes (CNFMs) were prepared successfully by a combination of electrospinning, heat treatment, and hydrothermal synthesis. The influence of the synthesis parameters on morphology, structure, and properties of the CNFMs was investigated, and the optimal process parameters were determined. Then, the CNFMs obtained with optimal process parameters were applied for the photocatalytic degradation of methyl orange. It was found that the CNFMs could be reused to degrade methyl orange at least three times, and the degradation rate remained above 90%. 631

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The fight against multidrug-resistant organisms: The role of ZnO crystalline defects

Cited by 22 publications

References 43 publications

The Benefits of the ZnO/Clay Composite Formation as a Promising Antifungal Coating for Paint Applications

The Benefits of the ZnO/Clay Composite Formation as a Promising Antifungal Coating for Paint Applications

Novel 1,2,3-Triazole-sulphadiazine-ZnO Hybrids as Potent Antimicrobial Agents against Carbapenem Resistant Bacteria

Preparation, characterization and photocatalytic performance of heterostructured CuO–ZnO-loaded composite nanofiber membranes

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