The fine structure of reovirus, a new member of the icosahedral series

Antibody-Mediated Immunity to Transplantable Tumors Following Reovirus Oncolysis

“…Hollow' particles generally constituted about 10-20% of total particles observed in any given field. The diameter of both complete and incomplete forms was estimated at about 60 to 70/*, in agreement with the findings of other workers (14,35). The virus appeared to develop in connection with cytoplasmic multi-membraned vesicles near the cell nucleus.…”

“…Figure 1 shows the developing reovirus in the Ehrlich ascites tumor cell 48 hours post-infection of the tumor in an A/.Jax mouse. I he morphological characteristics of Ihe virions seen are quite typical of Ihe reovirus group as described by others (14,32,35).…”

Sensitivity of bluetongue virus to lipid solvents, trypsin and pH changes and its serological relationship to arboviruses

“…Both viruses contain RNA, resist treatment with lipid solvents (Gomatos, Tamm, Dales & Franklin, 1962) and are trypsin sensitive (Gomatos & Tamm, 1962;Mayor & Jordan, 1965). Of interest in this context are results by Polson & Deeks (1963) indicating that African horse sickness virus, another serologically unclassified, RNA-containing and ether-resistant arbovirus, which also is unstable below pH 6 and transmitted by Culicoides spp., has an ultrastructure which closely resemblea that of reoviruses (Vasques & Tournier, 1962;Jordan & Mayor, 1962 buffer. Below pH 6 bluetongue was irreversibly inactivated within 1 min.…”

The Second Open Reading Frame of the Avian Reovirus S1 Gene Encodes a Transcription-Dependent and CRM1-Independent Nucleocytoplasmic Shuttling Protein

“…Avian reoviruses and mammalian reoviruses are members of the Orthoreovirus genus, 1 of the 11 genera of the Reoviridae family (22,37). These agents, which replicate in the cytoplasm of infected cells, lack a lipid envelope and contain a fragmented double-stranded RNA genome enclosed within a double protein capsid shell with a 70-to 80-nm external diameter.…”