The first 13-vinyl derivatives of berberine: synthesis and antimicrobial activity

Демехин, Олег Д.; Zagrebaev, Aleksander D.; Буров, Олег Н.; Клецкий, М. Е.; Pavlovich, Natal’ya V.; Березняк, Елена Александровна; Цимбалистова, Марина В.; Kurbatov, S. V.

doi:10.1007/s10593-019-02589-0

Cited by 11 publications

(2 citation statements)

References 14 publications

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“…Previous antimicrobial evaluations revealed that BBR and some of its derivatives exhibited potent anti‐bacterial activity against Gram‐positive bacterial strains (Olleik et al, 2020). The antibacterial activity of BBR was confirmed against Brucella Abortus, Vibrio cholera , Escherichia coli (Gram‐negative), and Staphylococcus aureus (Gram‐positive) using a serial dilution method on Mueller–Hinton agar with the minimum inhibitory concentration (MIC) values ranging from 0.82 to 13.18 μmol/L (Demekhin et al, 2019). BBR is known as a potential DNA‐targeting antimicrobial agent (Gaba et al, 2021).…”

Section: Biological Activity Of Bbr: a Focus On The Applicable Aspect...mentioning

confidence: 99%

An insight into the potential of berberine in animal nutrition: Current knowledge and future perspectives

Ghavipanje

Nasri

Vargas‐Bello‐Pérez

2022

Animal Physiology Nutrition

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In animal nutrition, the interest for novel feed additives has expanded with elevating industry standards and consumer awareness besides the demand for healthy animalderived food products. Consumer and animal health are leading concerns dictating the importance of novel animal feed additives. Berberine (BBR) is a natural pentacyclic isoquinoline alkaloid that has exhibited diverse pharmacological properties, including metabolism-regulating, hepatoprotective, and inflammatory alleviative in addition to its antioxidant activity. Despite detailed information on cellular mechanisms associated with BBR therapeutics, and strong clinical evidence, only a few studies have focused on BBR applied to animal nutrition. However, great pieces of evidence have shown that dietary BBR supplementation could result in improved growth performance, enhanced oxidoinflammatory markers, and mitigated metabolic dysfunctions in both monogastric and ruminant animals. The data discussed in the present review may set the basis for further research on BBR in animal diets for developing novel strategies aiming to improve animal health as well as products with beneficial properties for humans.

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Section: Biological Activity Of Bbr: a Focus On The Applicable Aspect...mentioning

confidence: 99%

An insight into the potential of berberine in animal nutrition: Current knowledge and future perspectives

Ghavipanje

Nasri

Vargas‐Bello‐Pérez

2022

Animal Physiology Nutrition

View full text Add to dashboard Cite

show abstract

“…31 Nucleophilic addition at the C-ring or nucleophilic substitution of the methoxy group in the D-ring are commonly employed for structural modification of berberine. Successful approaches, including those developed by our group, [32][33][34][35][36] involve umpolung strategies. 37 These approaches enable the reduction of the C-ring, followed by the use of electrophilic reagents to attack the C and D rings 10,29,[38][39][40][41] (Scheme 1).…”

Section: Introductionmentioning

confidence: 99%