The First Analysis and Clinical Evaluation of Native Breast Tissue Using Differential Phase-Contrast Mammography

Stampanoni, Marco; Wang, Zhentian; Thüring, Thomas; Dávid, Christian; Roessl, Ewald; Trippel, Mafalda; Ra, Kubik-Huch; Singer, Gad; Höhl, Michael; Hauser, Nik

doi:10.1097/rli.0b013e31822a585f

Cited by 244 publications

(215 citation statements)

References 25 publications

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“…This triggered many studies, for instance in the bio-medical imaging field [5][6][7], showing the potential of this technique for mainstream applicability. Although phase-shift interactions have a higher cross section than interactions by absorption for hard X-rays (δ/β ≈ 10 3 ), the eventual gain in the contrast-to-noise ratio (CNR) of two materials strongly depends on the imaging technique itself.…”

Section: Introductionmentioning

confidence: 99%

Performance and optimization of X-ray grating interferometry

Thuering

Stampanoni

2014

Phil. Trans. R. Soc. A.

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The monochromatic and polychromatic performance of a grating interferometer is theoretically analysed. The smallest detectable refraction angle is used as a metric for the efficiency in acquiring a differential phase-contrast image. Analytical formulae for the visibility and the smallest detectable refraction angle are derived for Talbot-type and Talbot-Lau-type interferometers, respectively, providing a framework for the optimization of the geometry. The polychromatic performance of a grating interferometer is investigated analytically by calculating the energydependent interference fringe visibility, the spectral acceptance and the polychromatic interference fringe visibility. The optimization of grating interferometry is a crucial step for the design of application-specific systems with maximum performance.

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Section: Introductionmentioning

confidence: 99%

Performance and optimization of X-ray grating interferometry

Thuering

Stampanoni

2014

Phil. Trans. R. Soc. A.

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“…Recently, using an X-ray Talbot-Lau grating interferometry (GI) 17,18 , we generated phase-contrast mammograms of non-fixed human whole-breasts samples ex vivo 19,20 . Our imaging technique records absorption, differential phase and smallangle scattering signals from the sample simultaneously 18,21 .…”

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confidence: 99%

“…Our imaging technique records absorption, differential phase and smallangle scattering signals from the sample simultaneously 18,21 . Especially for breast diagnostics, the GI technique may provide superior contrast compared with conventional absorption-based X-ray imaging, and might potentially reduce dose deposition to the sample 19 .…”

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confidence: 99%

Non-invasive classification of microcalcifications with phase-contrast X-ray mammography

et al. 2014

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Microcalcifications can be indicative in the diagnosis of early breast cancer. Here we report a non-invasive diagnostic method that may potentially distinguish between different types of microcalcifications using X-ray phase-contrast imaging. Our approach exploits the complementary nature of the absorption and small-angle scattering signals of microcalcifications, obtained simultaneously with an X-ray grating interferometer on a conventional X-ray tube. We demonstrate that the new approach has 100% sensitivity and specificity when applied to phantom data, and we provide evidence of the solidity of the technique by showing its discrimination power when applied to fixed biopsies, to non-fixed tissue specimens and to fresh, whole-breast samples. The proposed method might be further developed to improve early breast cancer diagnosis and has the potential to increase the diagnostic accuracy and reduce the number of uncomfortable breast biopsies, or, in case of widespread microcalcifications, to select the biopsy site before intervention.

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“…Propagation-based phase-contrast imaging (PPCI) [4] was applied, based on the high coherence of the synchrotron radiation (SR) beam. In fact, albeit other phase-sensitive techniques were successfully experimented in in vitro mammography [5][6][7][8], PPCI was preferred because of its simplicity in the experimental set-up, that allowed a straightforward translation to the in vivo application. Moreover, clinical mammography has very tight constraints in acquisition time because of the discomfort related to the breast compression and of the potential motion artefacts related to the physiologic motions of the human body (e.g.…”

Section: Introductionmentioning

confidence: 99%

Clinical study in phase- contrast mammography: image-quality analysis

Longo

Tonutti

Rigon

et al. 2014

Phil. Trans. R. Soc. A.

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The first clinical study of phase-contrast mammography (PCM) with synchrotron radiation was carried out at the Synchrotron Radiation for Medical Physics beamline of the Elettra synchrotron radiation facility in Trieste (Italy) in 2006-2009. The study involved 71 patients with unresolved breast abnormalities after conventional digital mammography and ultrasonography exams carried out at the Radiology Department of Trieste University Hospital. These cases were referred for mammography at the synchrotron radiation facility, with images acquired using a propagation-based phase-contrast imaging technique. To investigate the contribution of phase-contrast effects to the image quality, two experienced radiologists specialized in mammography assessed the visibility of breast abnormalities and of breast glandular structures. The images acquired at the hospital and at the synchrotron radiation facility were compared and graded according to a relative seven-grade visual scoring system. The statistical analysis highlighted that PCM with synchrotron radiation depicts normal structures and abnormal findings with higher image quality with respect to conventional digital mammography

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The First Analysis and Clinical Evaluation of Native Breast Tissue Using Differential Phase-Contrast Mammography

Cited by 244 publications

References 25 publications

Performance and optimization of X-ray grating interferometry

Performance and optimization of X-ray grating interferometry

Non-invasive classification of microcalcifications with phase-contrast X-ray mammography

Clinical study in phase- contrast mammography: image-quality analysis

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