The first and second phase of insulin secretion in naive Chinese type 2 diabetes mellitus

Lin, Jiunn Diann; Hsia, Te Lin; Wu, Chung Ze; Su, Ching Chieh; Wen, Ya; Hsieh, An Tsz; Hsieh, Chang Hsun; Wang, Kun; Chu, Yi-Min; Pei, Dee

doi:10.1016/j.metabol.2009.09.024

Cited by 20 publications

(15 citation statements)

References 36 publications

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“…Although it results from synthetic action involving insulin resistance and impaired insulin secretion [3], a detailed etiology underlying T2DM is still unclear. Meanwhile, T2DM is a major factor that along with other risk factors such as obesity, endothelial dysfunction, and dyslipidemia contribute to atherosclerotic diseases.…”

Section: Introductionmentioning

confidence: 99%

Genetic Polymorphism of Apolipoprotein A5 Gene and Susceptibility to Type 2 Diabetes Mellitus: A Meta-Analysis of 15,137 Subjects

Yin

Sun²,

Wang

et al. 2014

PLoS ONE

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BackgroundSeveral studies have investigated whether the polymorphism in the apolipoprotein A5 (APOA5) is associated with type 2 diabetes mellitus (T2DM) risk. However, those studies have produced inconsistent results. The purpose of this study was to investigate whether the APOA5 -1131T/C polymorphism (rs662799) confers significant susceptibility to T2DM using a meta-analysis.MethodsPubMed, Embase, Web of Science, Cochrane database, CBMdisc, CNKI and Google Scholar were searched to get the genetic association studies. All statistical analyses were done with Stata 11.0.ResultsA total of 19 studies included 4,767 T2DM cases and 10,370 controls (four studies involving 555 T2DM cases and 2958 controls were performed among Europeans and 15 studies involving 4212 T2DM cases and 7412 controls were performed among Asians) were combined showing significant association between the APOA5 -1131T/C polymorphism and T2DM risk (for C allele vs. T allele: OR = 1.28, 95% CI = 1.17–1.40, p<0.00001; for C/C vs. T/T: OR = 1.57, 95% CI = 1.35–1.83, p<0.00001; for C/C vs. T/C+T/T: OR = 1.36, 95% CI = 1.18–1.57, p<0.0001; for C/C+T/C vs. T/T: OR = 1.32, 95% CI = 1.16–1.51, p<0.0001). In the subgroup analysis by ethnicity, significant association was also found among Asians (for C allele vs. T allele: OR = 1.31, 95% CI = 1.22–1.40, p<0.00001; for C/C vs. T/T: OR = 1.61, 95% CI = 1.38–1.88, p<0.00001; for C/C vs. T/C+T/T: OR = 1.39, 95% CI = 1.20–1.61, p<0.0001; for C/C+T/C vs. T/T: OR = 1.42, 95% CI = 1.25–1.62, p<0.00001). However, no significant association was found between the APOA5 -1131T/C polymorphism and T2DM risk among Europeans.ConclusionsThe present meta-analysis suggests that the APOA5 -1131T/C polymorphism is associated with an increased T2DM risk in Asian population.

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Section: Introductionmentioning

confidence: 99%

Genetic Polymorphism of Apolipoprotein A5 Gene and Susceptibility to Type 2 Diabetes Mellitus: A Meta-Analysis of 15,137 Subjects

Yin

Sun²,

Wang

et al. 2014

PLoS ONE

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“…The growing global epidemic of T2DM is expected to increase from 171 million cases in 2000 to 366 millions in 2030 [2]. Although it results from synthetic action involving insulin resistance and impaired insulin secretion [3], a detailed etiology underlying T2DM is still unclear. Previous studies have reported that the prevalence rates of T2DM vary substantially throughout the world [4][5][6][7], and relatives of T2DM patients are at greater risk for developing the disease than the general population.…”

Section: Introductionmentioning

confidence: 99%

Association between interleukin-10 gene −592 C/A polymorphism and the risk of type 2 diabetes mellitus: A meta-analysis of 5320 subjects

Yin

Sun²,

Zhang

et al. 2012

Human Immunology

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“…However, the M-LDGGI is less time-and effort-consuming. This method has been described by our group elsewhere [14]. Second, it is generally agreed that measuring C-peptide during MTT might be more accurate than insulin.…”

Section: Conflict Of Interestmentioning

confidence: 99%

“…These two conditions limit the wide application of LDGGI. Our group proposed a modified LDGGI (M-LDGGI) and described its use in our previous study [14]. In brief, compared with the LDGGI, the M-LDGGI is shorter and contains fewer time points for blood drawing.…”

Section: Subjectsmentioning

confidence: 99%

Evaluation of second phase insulin secretion with simple surrogates derived from the mixed meal tolerance test in patients with type 2 diabetes

et al. 2013

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Abstract. The major contributors to the pathogenesis of type 2 diabetes are impaired insulin action and insulin secretion, including second phase insulin secretion (2 nd ISEC). This study aimed to compare surrogates derived from the mixed meal tolerance test (MTT) with 2 nd ISEC derived from modified low-dose graded glucose infusion (M-LDGGI) in patients with type 2 diabetes. We were subsequently able to decide which surrogate would be performed easily and accurately. Twenty type 2 diabetes patients were enrolled. They received both MTT and M-LDGGI. The standardized MTT meals were provided at 8:00 A.M. and 12:00 P.M. The M-LDGGI was a simplified version of the Polonsky method; only two 80-min stages of glucose infusion (2 and 6 mg/kg/min) were given. The slopes of the insulin to glucose curve during the test were regarded as the 2 nd ISEC. First, we used the area under the insulin curve (AUC IN ) during MTT to quantify the 2 nd ISEC. The best correlated AUC IN was from 60-240 min. Second, the slopes between any two time points of the plasma insulin to glucose level (SLOPE I/G ) were also assessed. The time period best correlated with 2 nd ISEC was from 0-120 min (SLOPE 0-120 ). Finally, the insulin-toglucose ratio (IG r ) of each time point was used to estimate the 2 nd ISEC, and the best correlation was observed at 180 min. In conclusion, estimating 2 nd ISEC surrogates derived from MTT proved to be possible. The most accurate surrogate is the SLOPE 0-120 , while IG r180 is another less precise but more convenient method.

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The first and second phase of insulin secretion in naive Chinese type 2 diabetes mellitus

Cited by 20 publications

References 36 publications

Genetic Polymorphism of Apolipoprotein A5 Gene and Susceptibility to Type 2 Diabetes Mellitus: A Meta-Analysis of 15,137 Subjects

Genetic Polymorphism of Apolipoprotein A5 Gene and Susceptibility to Type 2 Diabetes Mellitus: A Meta-Analysis of 15,137 Subjects

Association between interleukin-10 gene −592 C/A polymorphism and the risk of type 2 diabetes mellitus: A meta-analysis of 5320 subjects

Evaluation of second phase insulin secretion with simple surrogates derived from the mixed meal tolerance test in patients with type 2 diabetes

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