2015
DOI: 10.1111/voxs.12178
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The first case of foetal neonatal alloimmune thrombocytopenia caused by anti‐HPA‐1a antibodies in Asian population

Abstract: Background and Objectives The foetal neonatal platelet alloimmune thrombocytopenia (FNAIT) is one of the most frequent clinical implications of immunization against human platelet antigen (HPA). Maternal IgG platelet alloantibodies induce the destruction of foetal platelets leading to thrombocytopenia. In Caucasian, alloantibodies against HPA‐1a are responsible for the majority of severe FNAIT. As the frequency of HPA‐1bb homozygous individuals is very low in Asia, the clinical relevance of anti‐HPA‐1a alloant… Show more

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“…Whereas HPA‐1a represents the common cause of alloimmunization in Caucasians, this alloantigen does not seem to play an important role in Asian population ; almost all South‐East Asian individuals seem to be HPA‐1a positive . However, a rare case of FNAIT caused by anti‐HPA‐1a antibodies has been observed recently among Malay .…”
Section: Introductionmentioning
confidence: 99%
“…Whereas HPA‐1a represents the common cause of alloimmunization in Caucasians, this alloantigen does not seem to play an important role in Asian population ; almost all South‐East Asian individuals seem to be HPA‐1a positive . However, a rare case of FNAIT caused by anti‐HPA‐1a antibodies has been observed recently among Malay .…”
Section: Introductionmentioning
confidence: 99%