The first case of genotype 4 hepatitis E related to wild boar in South Korea

Kim, Yeo Myeong; Jeong, Sook‐Hyang; Kim, Jong Yeop; Song, Joon Chang; Lee, Ji Hye; Kim, Jin-Wook; Yun, Haesun; Kim, Jin Seon

doi:10.1016/j.jcv.2010.11.005

Cited by 55 publications

(37 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The HEV molecular epidemiology has been found to be complex in this country, as several HEV-4 subtypes, including subtypes b and d, have been detected, and sequences recovered from humans were found (although inconsistently) to share a high level of nucleotide similarity with those found from swine in the same geographical area [19,20,22]. Otherwise, HEV-4 have been collected in India, Indonesia, South Korea, Taiwan and Vietnam [18,20,23,24,25,26,27], including in autochthonous hepatitis E, and an epidemiological link with pigs or wild boars has been observed in cases diagnosed in Bali and South Korea [14,23,25]. In addition, HEV-4 infection was reported in 2010 in England in a patient who returned from a 2-month stay in India 1 month before presenting jaundice [28].…”

Section: Figmentioning

confidence: 99%

Emergence of Autochthonous Infections with Hepatitis E Virus of Genotype 4 in Europe

et al. 2013

View full text Add to dashboard Cite

In Europe, autochthonous hepatitis E is caused by genotype 3 hepatitis E virus (HEV) in almost all cases. A total of 15 infections with genotype 4 HEV were diagnosed in France from May 2009 to April 2012, and all but one of the HEV-4 strains implicated in these infections were genetically related and highly similar to HEV-4 sequences isolated from swine in Belgium. In addition, 5 autochthonous HEV-4 infections have been described in the region of Lazio, Italy, during March and April 2011, and these HEV sequences were 100% identical to one another but showed relatively low similarity (74-85%) to HEV-4 RNA samples collected in France. We report 6 additional HEV-4 infections that were diagnosed from May to July 2012 which represented 50% of the HEV infections diagnosed during this period in our clinical microbiology laboratory. Five of these HEV-4 strains were associated with autochthonous infections and were clustered together and with the majority of HEV-4 previously described in France, whereas the sixth strain was genetically divergent. Taken together with reports from other teams, these observations indicate that autochthonous infections with HEV-4 are emerging in Europe and have been transmitted by at least two distinct sources.

show abstract

Section: Figmentioning

confidence: 99%

Emergence of Autochthonous Infections with Hepatitis E Virus of Genotype 4 in Europe

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Therefore, other animals including zoo animals would also be infected with HEV through the same route as demonstrated in humans and pigs. A considerable portion HEV infection in humans is mediated by consumption of raw or under-cooked animal products or by direct contact with HEV-infected animals [5,6,10]. Therefore, zoo animal species are implicated as another risk factor for transmission of HEV to humans.…”

Section: Hepatitis E Virus (Hev) Is An Emerging Zoonotic Agentmentioning

confidence: 99%

Seroprevalence of hepatitis E virus in zoo animal species in Korea

Song¹,

Kim²,

Park³

et al. 2013

Korean Journal of Veterinary Research

View full text Add to dashboard Cite

: Hepatitis E virus (HEV) can infect not only human but also several animals. This study has been conducted to evaluate the comprehensive anti-HEV seroprevalence in zoo animals in Korea. Anti-HEV antibodies were identified in 14 of 64 zoo animal species. HEV antibodies were detected for the first time in Eurasian Lynx, Setland Pony, Fallow Deer, Ezo Sika, Formosa Deer, East Wapitis, Barasingha, Corriedale, American Bison, Guanacos, Reticulated Giraffe, and Saanen. These results indicate that the several zoo animal species were exposed to HEV.Keywords : hepatitis E virus, seroprevalence, zoo animal species Hepatitis E virus (HEV) is an emerging zoonotic agent. HEV is the only member of the genus Hepevirus in the family Hepeviridae. HEV is a non-enveloped virus that has an approximately 7.2 kb single-stranded genome comprised of positive-sense RNA [7]. HEV strains have been classified into four major genotypes based on phylogenetic analysis of full genome sequences or highly conserved partial sequences [7]. HEV infections by genotypes 1 and 2 are restricted to humans and cause mainly waterborne outbreak of hepatitis in developing countries. However, HEV genotypes 3 and 4 are detected in both humans and animals, and induce sporadic cases of acute hepatitis in developed countries. Human infections by HEV genotypes 3 and 4 are possibly transmitted from animal species including pigs and wild boar [8]. Previous serological studies in human, pig, and cat populations in Korea reported seroprevalence of anti-HEV antibody as 18%, 15%, and 8.1%, respectively [3,12]. However, no reports have addressed the seroprevalence study in zoo animal species. This study was conducted to evaluate the comprehensive anti-HEV seroprevalence status in zoo animal species in Korea.This study was conducted to evaluate comprehensively the anti-HEV seroprevalence in zoo animal species. A total of 201 serum samples were obtained from zoo animals at a Seoul Zoo, Korea from 2005 to 2010. The samples were stored at -80 o C until analysis. The samples were all tested in duplicate for anti-HEV antibody with a direct sandwich enzyme immunoassay kit (Wantai Biopharmaceutical, China). The assay was carried out by following the manufacturer's instructions. Briefly, 50 µL of the serum sample was added to each well containing 50 µL of the diluent, and the microplate was incubated for 30 min at 37 o C. The microplate was washed five times with 350 µL of a wash solution. 100 µL of horseradish peroxidase-conjugated recombinant HEV antigen was added to each well, and the microplate was incubated for 30 min at 37 o C. The microplate was washed five times with 350 µL of a wash solution. 50 µL of chromogen A and chromogen B solution were added into each well, and the microplate was incubated at 37 o

show abstract

“…However, reports of locally acquired HEV infection have recently increased in non-endemic areas; these cases were associated with zoonotic transmission, particularly by consumption of uncooked animal meat (Tamada et al, 2004). Additionally, Kim et al, (2011) reported the first case of zoonotic transmission of HEV (genotype 4) in a patient who developed acute hepatitis E after ingestion of raw bile juice from a wild boar living on a domestic mountain in Korea. It was suggested that wild boar could be a potential risk factor for zoonotic HEV transmission to humans (Tamada et al, 2014;Yugo and Meng, 2013).…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, anti-HEV antibodies were detected in 14 of 64 zoo animal species at different ratios (Song et al, 2013). However, no reports have addressed the seroprevalence of anti-HEV antibodies in wild boar populations in Korea, even though a wild boar-related human HEV infection has already been reported (Kim et al, 2011). Therefore, in the present study, we conducted a nationwide serological survey using enzyme-linked immunosorbent assay (ELISA) to investigate the prevalence of anti-HEV antibodies in wild boars in Korea.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of antibodies against hepatitis E virus in wild boars (Sus scrofa) in Korea

Park¹,

박지영²,

Kang³

et al. 2016

Korean Journal of Veterinary Service

View full text Add to dashboard Cite

We determined the nationwide seroprevalence of hepatitis E virus (HEV) infection in the wild boar population in Korea. Enzyme-linked immunosorbent assay (ELISA) results showed that 42% of the 528 wild boars that were hunted between 2013 and 2014 were anti-HEV antibody positive. Furthermore, all Korean provinces showed an HEV seroprevalence between 9.8% and 51.1%, suggesting that wild boar HEV infection occurs throughout the country. Importantly, infected wild boar could act as a potential reservoir for HEV and could aid transmission to other animals and humans.

show abstract

The first case of genotype 4 hepatitis E related to wild boar in South Korea

Cited by 55 publications

References 20 publications

Emergence of Autochthonous Infections with Hepatitis E Virus of Genotype 4 in Europe

Emergence of Autochthonous Infections with Hepatitis E Virus of Genotype 4 in Europe

Seroprevalence of hepatitis E virus in zoo animal species in Korea

Prevalence of antibodies against hepatitis E virus in wild boars (Sus scrofa) in Korea

Contact Info

Product

Resources

About