The first case of Lassa fever imported from Mali to the United Kingdom, February 2009

Atkin, Sara; Anaraki, S; Gothard, Philip; Walsh, Amanda L.; Brown, David W.; Gopal, Robin; Hand, Julie; Morgan, Dilys

doi:10.2807/ese.14.10.19145-en

Cited by 68 publications

(12 citation statements)

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“…In a recent study, four infected monkeys all survived infection with a similar dose of LASV AV [ 13 ]. These observations suggest that strains from lineage V, which have, thus far, caused only two known human deaths [ 24 , 25 ], are less pathogenic than strains from other lineages. But it is not the case in all lineages.…”

Section: Discussionmentioning

confidence: 99%

Pathogenesis of recent Lassa virus isolates from lineages II and VII in cynomolgus monkeys

et al. 2022

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The area of Lassa virus (LASV) circulation is expanding, with the emergence of highly pathogenic new LASV lineages. Benin recently became an endemic country for LASV and has seen the emergence of a new LASV lineage (VII). The first two outbreaks in 2014 and 2016 showed a relatively high mortality rate compared to other outbreaks. We infected cynomolgus monkeys with two strains belonging to lineage II and lineage VII that were isolated from deceased patients during the 2016 outbreak in Benin. The lineage VII strain (L7) caused uniform mortality. Death was associated with uncontrolled viral replication, unbalanced inflammatory responses characterized by increased concentrations of pro- and anti-inflammatory mediators, and the absence of efficient immune responses, resembling the pathogenesis associated with the prototypic Josiah strain in monkeys. The lineage II strain (L2) showed apparently lower virulence than its counterpart, with a prolonged time to death and a lower mortality rate. Prolonged survival was associated with better control of viral replication, a moderate inflammatory response, and efficient T -cell responses. Transcriptomic analyses also highlighted important differences in the immune responses associated with the outcome. Both strains caused strong inflammation in several organs. Notably, meningitis and encephalitis were observed in the cerebral cortex and cerebellum in all monkeys, independently of the outcome. Due to their apparently high pathogenicity, emerging strains from lineage VII should be considered in preclinical vaccine testing. Lineage II would also be beneficial in pathogenesis studies to study the entire spectrum of Lassa fever severity.

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Section: Discussionmentioning

confidence: 99%

Pathogenesis of recent Lassa virus isolates from lineages II and VII in cynomolgus monkeys

et al. 2022

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“…In recent imported cases of Lassa fever, a period of up to 16 days (median of 10 d) was taken to identify patients as potentially infected. [1][2][3] Thus, we have highlighted the need for laboratory diagnostic tools to assist in differential diagnosis of dengue fever, particularly in travelers from Lassa fever and yellow fever endemic regions.…”

Section: Response To Lettermentioning

confidence: 99%

Response to Letter

et al. 2013

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“…Lassa fever (LF) is an acute viral zoonotic illness caused by the Lassa virus (an arenavirus); it is characterized by fever, muscle ache, sore throat, nausea, vomiting, and chest and abdominal pain [1]. Approximately 29 imported LF cases were documented worldwide, and one-third of which was fatal [2][3][4][5][6]. LF is endemic in West African countries (Nigeria, Sierra Leone, Guinea, and Liberia).…”

Section: Introductionmentioning

confidence: 99%

Risk factors for Lassa fever infection among survivors at the Federal Medical Center, Owo, Ondo State, Nigeria

et al. 2021

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Background and Aim: There is insufficient information about the successfully managed Lassa fever (LF) patients in Nigeria. This study aimed to utilize the One Health approach to identify the risk factors for LF infection among LF patients who were managed and on follow-up at the Federal Medical Center, Owo, Ondo State, Nigeria. Materials and Methods: A cross-sectional study was done on 101 LF survivors who were managed and on follow-up at the Federal Medical Center. The data were collected using a semi-structured interviewer-administered questionnaire. The respondents were assessed for symptoms and factors that might have predisposed them to LF, and the data were analyzed with SPSS version 23 (IBM Corp., NY, USA). Those who had more than 3 identifiable risks were categorized as high risk. Descriptive statistics were done, and the association between sociodemographic characteristics and high risk was explored using Chi-square test. Results: The median age of the respondents was 33 years (8-85 years); 62 (61.4%) were male, and 93 (92.1%) have heard of LF before diagnosis. The perceived cause of LF infection among the respondents included the consumption of food contaminated by rats' feces among 57 (56.4%) persons, while 16 (15.8) attributed their infection to contact with LF-infected persons. Among the respondents with primary education and below, 5 (29.4%) were at higher risk for LF infection compared to 7 (8.3%) with secondary education and above (p=0.014). Conclusion: The mass media and other sources of information should be well-harnessed in the communication of risks and preventive practices for LF. Public information campaigns should be organized to discourage bush burning in affected communities.

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The first case of Lassa fever imported from Mali to the United Kingdom, February 2009

Abstract: This is the first case of Lassa fever to be imported from Mali to the United Kingdom. This paper discusses the investigations, the virological analysis, the surveillance and management of contacts undertaken following a case of Lassa fever.

Cited by 68 publications

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Pathogenesis of recent Lassa virus isolates from lineages II and VII in cynomolgus monkeys

Pathogenesis of recent Lassa virus isolates from lineages II and VII in cynomolgus monkeys

Response to Letter

Risk factors for Lassa fever infection among survivors at the Federal Medical Center, Owo, Ondo State, Nigeria

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