The First Case of Omental Metastasis from Primary Choroidal Melanoma

Zhao, Hong; Mi, Yang; Zhang, Xiaosan; Yao, Guo‐Dong; Zhou, Dajun; Wang, Yan; Zhang, Qingyuan

doi:10.1093/jjco/hys229

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…Malignant melanoma, depending on the localization, invades the environment, by spreading through lymphatics and hematogenously. Metastatic melanoma of the forehead skin and the eye presented in our patients most likely originates from hematogenous dissemination, as evidenced by angioinvasion stromal metastases, as pointed out by other authors (21)(22)(23)(24)(25)(26).…”

Section: Discussionsupporting

confidence: 78%

Rare Metastases of Malignant Melanoma

Trenkic-Božinović¹,

Katić²,

Nagorni³

et al. 2014

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Melanomas are malignant neoplasms that originate from melanocytes. The most common are on the skin and mucous membranes. Choroidal melanomas are quite different from cutaneous melanomas with regard to presentation, metastases, and treatment.We report two cases of metastatic gastric malignant melanoma of the eye and skin, with reference to the literature. The first patient was a woman aged 23 years, who underwent gastrectomy 22 months after enucleation of the eye due to malignant choroid melanoma. The second patient was a man, 72 years old, who underwent surgery 28 months before because of malignant melanoma of the skin of the forehead. Paraffin sections, 4 μm thick were stained using a classic method, as well as immunohistochemical DAKO APAAP method, using a specific S -100 antibody and Melan A antibodies.The stomach is considered a rare place for the development of metastases. Metastases in the stomach are often limited to the submucosal as well as the serousmuscular layer, as noted in one of our patients. Metastatic melanoma of the gastrointestinal tract should be suspected in any patient with a history of malignant melanoma and new gastrointestinal symptoms. Because of the similarity between certain common histopathological types of malignant melanoma, primarily achromatic, and types of primary cancers of the stomach, the following immunohistochemical studies are needed: Melan A and S -100 protein ( markers of malignant melanoma ), as well as mucins: MUC5AC, MUC2 and CDX2 ( markers of different types of primary gastric carcinoma).

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Section: Discussionsupporting

confidence: 78%

Rare Metastases of Malignant Melanoma

Trenkic-Božinović¹,

Katić²,

Nagorni³

et al. 2014

amm

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“…The only similar case, published by Zhao et al [3] is of a melanoma of choroidal origin metastasising to the omentum [3]. …”

Section: Discussionmentioning

confidence: 99%

Synchronous metastatic omental melanoma and colonic adenocarcinoma: a case report

et al. 2015

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BackgroundMalignant melanoma is a rare malignancy of the skin with very high mortality rates. Distal metastases are common especially to other areas of the skin, subcutaneous tissues lungs or liver. There are no previously reported cases of skin melanoma metastasizing to the omentum.Case presentationA 62 year-old white British man with a past medical history of a malignant melanoma of the skin underwent a laparotomy for a partially obstructing sigmoid tumour. Intra-operatively, a round, smooth textured black lesion was identified on the anterior surface of the omentum; the nodule was confirmed to be a metastatic malignant melanoma with abundant brown pigment and a focal necrotic area.ConclusionA metastatic malignant melanoma was discovered incidentally on the omentum during a laparotomy for bowel obstruction. The significance of this is unclear but it is possible that the omentum may have played a protective role in limiting its spread systemically.

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“…Limited burden of disease do best with surgical treatment. Cases of omental metastases of melanoma are extremely unusual in the literature [10], [11], [12]. Either complete surgical resection or chemotherapy should be chosen as option treatments in such uncommon patients.…”

Section: Discussionmentioning

confidence: 99%

“…Although, melanoma is a tumor with a behavior that is not always predictable, there have been very few reports published of melanoma metastasizing to rectus abdominis muscle [7], [8], [9], and fewer publications of melanoma metastasizing to the omentum, which is an extremely rare site for metastasis [10], [11], [12]. As the condition is so rare, there is no consensus on the best treatment and proper chemotherapy [13].…”

Section: Introductionmentioning

confidence: 99%