The first case of synchronous cellular angiofibromas of the scrotum

Hsu, Chih Chen; Fang, Chia Lang; Chien, Chin Wei; Hsiao, Chi Hao; Lee, Liang Ming

doi:10.1016/j.urols.2015.01.011

Cited by 6 publications

(13 citation statements)

References 8 publications

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“…The testicular tumor markers, which are the hCG and alpha-fetoprotein, are at a normal rate as that described in our case [5]. Testicular ultrasound usually shows a solid hypoechoic lesion [1, 3]. Macroscopically, the tumor is usually solid.…”

Section: Discussionsupporting

confidence: 59%

“…Histologically, the nomenclature, angiofibroblastoma, is based on the two main components of the tumor: blood vessels and connective tissue. This has been observed in the majority of reported cases [1–9]. The tumor is well circumscribed, even encapsulated [1, 2, 5, 7, 10].…”

Section: Discussionmentioning

confidence: 84%

“…This has been observed in the majority of reported cases [1–9]. The tumor is well circumscribed, even encapsulated [1, 2, 5, 7, 10]. Intralesional fat tissue can sometimes be present [1–3].…”

Section: Discussionmentioning

confidence: 98%

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Paratesticular Angiomyofibroblastoma-Like Tumor: Unusual Case of a Solidocystic Form

Msakni

Ghachem

Bani

et al. 2017

Case Reports in Medicine

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The angiomyofibroblastoma-like tumor of the male genital tract is a rare benign tumor. A total of 34 cases have been reported in the literature. We herein report an exceptional case of solidocystic form in its paratesticular location, in a 79-year-old man. Clinical examination objectified a right testicular induration. Macroscopic examination of the orchidectomy objectified a paratesticular solidocystic tumor formation. Microscopically, the solid area was composed of vessels with small caliber and turgidity of endothelial cells. These vessels were surrounded by clusters of epithelioid cells, sometimes having the appearance of giant cells. They were associated with spindle cells. The cystic area was uncoated. Immunohistochemically, the fusiform cells expressed Desmin and Smooth Muscle Actin. Endothelial cells and clusters of cells surrounding large vessels expressed CD34. The expression of receptors for estrogen and progesterone was negative. To our knowledge, this is the second solidocystic case of angiomyofibroblastoma-like tumor of male genital tract.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 84%

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Paratesticular Angiomyofibroblastoma-Like Tumor: Unusual Case of a Solidocystic Form

Msakni

Ghachem

Bani

et al. 2017

Case Reports in Medicine

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“…In spindle cell lipoma, the adipose tissue is the main component and the lesion is mostly identified in the head and neck regions. In solitary fibrous tumour, the blood vessels are elongated or ramified and display a staghorn architecture [11]. A lipomatous variant of AMF with presence of adipocytes ≥ 30% and possible sarcomatous transformation was also described.…”

Section: Discussionmentioning

confidence: 99%

Angiomyofibroblastoma mimicking an inguinal hernia: a challenging diagnosis in a male patient

Banias

Gurzu

Jung

et al. 2019

pdia

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Introduction Angiomyofibroblastoma is a rare benign myofibroblastic neoplasm which mainly occurs in the soft tissues of the pelvi-perineal region of females. Aim To present an unusual case of angiomyofibroblastoma mimicking an inguinal hernia in a 62-year-old male. Material and methods The patient was hospitalized with an irreducible, painless inguinal mass and surgical intervention for inguinal hernia was decided. The well-defined nodular mass was sent for histological examination. Results Under microscope, proliferation of spindle and oval cells around thin-walled vessels was observed, being intermingled with mature adipocytes. We did not identify necrosis, haemorrhage, cytologic atypia or mitotic figures. The tumour cells displayed positivity for desmin, vimentin, CD34, oestrogen and progesterone receptors, a low Ki67 index and unusual nuclear positivity for c-theta (PKCθ). They were negative for smooth muscle actin (SMA), S100, CD44, maspin, synaptophysin, DOG1 and CD117. The case was diagnosed as angiomyofibroblastoma, the main challenge being the differential diagnosis with aggressive angiomyxoma, which can present a similar histologic aspect and immunophenotype and recurs more frequently. No recurrences were observed 8 months after the surgery. Conclusions Angiomyofibroblastoma should be included in the differential diagnosis of inguinal hernia. This is the fourteenth case of angiomyofibroblastoma diagnosed in males.

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“…[ 1 ] In cellular angiofibroma, ultrasonography typically shows a solid mass with heterogeneous echogenicity. [ 5 6 7 8 9 10 ] These features, however, are inadequate to differentiate between benign and malignant lesion. Hence, further imaging naturally is required to evaluate further the mass.…”

Section: Discussionmentioning

confidence: 99%

Imaging modalities for an uncommon inguinal scrotal pathology: A case report and literature review

et al. 2017

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Inguinal scrotal swelling is a common presentation to surgical clinic with various differential diagnoses. In most circumstances, a good clinical assessment is sufficient to identify the diagnosis. Imaging is necessary when diagnostic difficulty was encountered. The choice of imaging study could affect the management and outcome. A 60-year-old male presented with an enlarging right inguinal scrotal swelling for 5 years. Clinical examination showed a swelling extended from the right inguinal region down to the right scrotum, firm, not reducible, and not separable from the right testis. Differential diagnoses range from the malignant testicular tumor, irreducible inguinal hernia to the soft-tissue tumor. Ultrasonography and computed tomography scan were unable to conclude the origin of the tumor and involvement of the right testis. Inguinal exploration with potential radical orchiectomy was planned and caused much distress to the patient, resulted in delay in surgery. Intraoperatively, the mass was separated from the testis and spermatic cord, and thus, excision biopsy was performed sparing the testis and spermatic cord. Histopathological examination showed cellular angiofibroma. The right choice of imaging modality is important to provide a precise diagnosis and better treatment plan. This could avoid the unnecessary distress to the patient for potential organ lost. A review through the literature showed the ability of magnetic resonance imaging to better delineate the anatomy of inguinal scrotal soft-tissue mass and thus should have been the imaging modality of choice.

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The first case of synchronous cellular angiofibromas of the scrotum

Cited by 6 publications

References 8 publications

Paratesticular Angiomyofibroblastoma-Like Tumor: Unusual Case of a Solidocystic Form

Paratesticular Angiomyofibroblastoma-Like Tumor: Unusual Case of a Solidocystic Form

Angiomyofibroblastoma mimicking an inguinal hernia: a challenging diagnosis in a male patient

Imaging modalities for an uncommon inguinal scrotal pathology: A case report and literature review

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