The First Case Report of Acute Cholangitis and Bacteremia Due to &lt;i&gt;Neisseria subflava&lt;/i&gt;

Uwamino, Yoshifumi; Sugita, Kayoko; Iwasaki, Eisuke; Fujiwara, Hiroshi; Nishimura, Tomoyasu; Hasegawa, Naoki; Iwata, Satoshi

doi:10.2169/internalmedicine.56.7482

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…We identified two genus Escherichia-Shigella in the R. norvegicus intestines, reportedly responsible for human gastrointestinal disorders (Belotserkovsky and Sansonetti, 2018). The commensal species Neisseria subflava identified in our current study is a rare cause of invasive diseases like meningitis, endocarditis, bacteremia, pericarditis, and septic arthritis in humans (Uwamino et al, 2017). S. azizii (associated with meningoencephalitis in newborn weanling C57BL/6 mice) was et al, 2021).…”

Section: Discussionsupporting

confidence: 51%

Comparative analysis of the intestinal microbiome in Rattus norvegicus from different geographies

Shah,

Hou,

Jiang

et al. 2023

Front. Microbiol.

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Rat species Rattus norvegicus, also known as the brown street rat, is the most abundant mammal after humans in urban areas, where they co-exist with humans and domestic animals. The reservoir role of R. norvegicus of zoonotic pathogens in cities among rodent-borne diseases that could endanger the lives of humans and other mammals. Therefore, understanding the normal microbiome of R. norvegicus is crucial for understanding and preventing zoonotic pathogen transmission to humans and animals. We investigated the intestinal microbiome of free-living R. norvegicus collected from the Ruili, Nujiang, and Lianhe regions of Yunnan, China, using 16S rRNA gene sequence analysis. Proteobacteria, followed by Firmicutes, and Bacteroidetes were abundant in the intestines of R. norvegicus; however, bacterial compositions varied significantly between samples from different locations. Following a similar trend, Gammaproteobacteria, Bacilli, and Clostridia were among the top bacterial classes in most intestinal samples. The situation differed slightly for the Lianhe and Nujiang samples, although Phyla Bacteroidota and Spirochaetota were most prevalent. The Alpha diversity, Chao1, and Simpson indexes revealed microbial richness among the R. norvegicus samples. A slight variation was observed among the samples collected from Ruili, Nujiang, and Lianhe. At species levels, several opportunistic and zoonotic bacterial pathogens, including Lactococcus garvieae, Uruburuella suis, Bartonella australis, Clostridium perfringens, Streptococcus azizii, Vibrio vulnificus, etc., were revealed in the R. norvegicus intestines, implying the need for a regular survey to monitor and control rodent populations. In conclusion, we explored diverse microbial communities in R. norvegicus intestines captured from different regions. Further, we identified several opportunistic and potential bacterial pathogens, which still need to be tested for their underlying pathogenesis. The findings of our current study should be considered a warning to the health authorities to implement rat control and surveillance strategies globally.

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Section: Discussionsupporting

confidence: 51%

Comparative analysis of the intestinal microbiome in Rattus norvegicus from different geographies

Shah,

Hou,

Jiang

et al. 2023

Front. Microbiol.

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“…lactamica , occasionally cause invasive infections in humans. These infections include meningitis, endocarditis, ocular infections, pericarditis, empyema, peritonitis, septic arthritis, bursitis and osteomyelitis that were primarily based on individual case reports [5–10].…”

Section: Introductionmentioning

confidence: 99%

“…are part of the normal flora of the upper respiratory tract, although certain species, such as N. sicca, N. subflava, N. cinerea and N. lactamica, occasionally cause invasive infections in humans. These infections include meningitis, endocarditis, ocular infections, pericarditis, empyema, peritonitis, septic arthritis, bursitis and osteomyelitis that were primarily based on individual case reports [5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Evidence of horizontal gene transfer within porB in 19 018 whole-genome Neisseria spp. isolates: a global phylogenetic analysis

et al. 2023

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The PorB porins are the major pore-forming proteins in the genus Neisseria . The trimeric PorB porins consist of 16 highly conserved transmembrane domains that form an amphipathic β-sheet connected by short periplasmic turns and eight extracellular hydrophilic loops. These loops are immunogenic and also play an important role in mediating antimicrobial influx. This study sought to (i) characterize the variations in Neisserial loop 3(355–438 bp) associated with intermediate resistance to penicillin/tetracycline and (ii) evaluate if there was evidence of horizontal gene transfer in any of the loops. We collated an integrated database consisting of 19 018 Neisseria spp. genomes – 17 882 Neisseria gonorrhoeae , 114 Neisseria meningitidis and 1022 commensal Neisseria spp. To identify the porB alleles, a gene-by-gene approach (chewBBACA) was employed. To evaluate the presence of recombination events, the Recombination Detection Programme (RDP4) was used. In total, 3885 porB alleles were detected. Paralogues were identified in 17 Neisseria isolates. Putative recombination was identified in loop regions. Intraspecies recombination among N. gonorrhoeae isolates and interspecies recombination between N. meningitidis and commensal Neisseria spp., and N. gonorrhoeae and N. lactamica were identified. Here, we present a large-scale study of 19 018 Neisseria isolates to describe recombination and variation in the porB gene. Importantly, we found putative recombination in loop regions between the pathogenic and non-pathogenic Neisseria spp. These findings suggest the need for pheno- and genotypic surveillance of antimicrobial susceptibility in commensal Neisseria spp. to prevent the emergence of AMR in the pathogenic Neisseria . This article contains data hosted by Microreact.

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Beyond the usual suspects: Reviewing infections caused by typically-commensal Neisseria species

Walsh,

Clark,

Derrick

et al. 2023

Journal of Infection

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The First Case Report of Acute Cholangitis and Bacteremia Due to <i>Neisseria subflava</i>

Cited by 5 publications

References 10 publications

Comparative analysis of the intestinal microbiome in Rattus norvegicus from different geographies

Comparative analysis of the intestinal microbiome in Rattus norvegicus from different geographies

Evidence of horizontal gene transfer within porB in 19 018 whole-genome Neisseria spp. isolates: a global phylogenetic analysis

Beyond the usual suspects: Reviewing infections caused by typically-commensal Neisseria species

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