The first case report of Pityriasis lichenoides chronica following COVID ‐19 mRNA vaccination

Abstract

Many cutaneous adverse reactions to the Coronavirus disease-2019 (COVID-19) vaccines have been reported. Delayed reactions, which occur following several days or weeks, either involve new onset cutaneous disorder or flare of preexisting dermatomes. Here, we report the first case of new onset Pityriasis lichenoides chronica (PLC) following the Pfizer-BioNTech COVID-19 mRNA vaccine, aiming to highlight their possible association.An adolescent 16-year-old boy experienced gradual onset of asymptomatic scaly erythematous papules over his trunk (Figure 1A, B). The eruption started 1 week after the first dose of the Pfizer-BioNTech COVID-19 vaccine. However, the patient did not seek medical advice or receive any treatment. Following the second dose, the eruption increased progressively all over the trunk and extremities, with the appearance of numerous purpuric lesions. Mucous mem-

Pityriasis Lichenoides Following SARS-CoV-2 Infection/Vaccination

“…Thirteen articles, comprising 14 cases of PL following SARS-CoV-2 infection/vaccination, were included [6][7][8][9][10][11][12][13][14][15]16 Studies excluded during title/abstract screen (n = 10)…”

Pityriasis Lichenoides et Varioliformis Acuta as a Complication of COVID-19 Infection

“…Our case similarly demonstrated a CD30 (+) infiltrate and a positive TCR− γ gene rearrangement study. Recently, 11 patients with PLEVA induced by a COVID-19 infection [ 9 , 10 ] and 7 by the COVID-19 vaccine [ 11 , 12 , 13 , 14 , 15 , 16 , 17 ] have been reported in the literature ( Table 1 ). In the setting of a recent COVID-19 infection, these findings suggest that COVID-19 should likely be added to the list of possible viral agents capable of inducing PLEVA.…”

“…The pathogenesis of PLEVA is unclear. Current theories include infectious etiologies with pathogenic culprits including human immunodeficiency virus, human herpesvirus 7, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and parvovirus B19 [2,3] [11][12][13][14][15][16][17] have been reported in the literature (Table 1). In the setting of a recent COVID-19 infection, these findings suggest that COVID-19 should likely be added to the list of possible viral agents capable of inducing PLEVA.…”

Pityriasis lichenoides chronica induced by COVID-19 messenger RNA vaccination

“…1 Further, it has been linked to many possible inciting agents, such as Toxoplasma gondii, Epstein-Barr virus, human immunodeficiency virus, cytomegalovirus, and varicella-zoster virus, in addition to different types of vaccines. [1][2][3][4][5][6][7][8][9][10][11] Vaccines reported as possible inciting triggers include vaccines for human papillomavirus, measles, mumps, rubella, tetanus, diphtheria, influenza, and COVID-19. [1][2][3][4][5][6][7][8][9][10][11][12] In this article, we present the second case report of PLC triggered by the Pfizer-BioNTech COVID-19 vaccine.…”

“…[1][2][3][4][5][6][7][8][9][10][11] Vaccines reported as possible inciting triggers include vaccines for human papillomavirus, measles, mumps, rubella, tetanus, diphtheria, influenza, and COVID-19. [1][2][3][4][5][6][7][8][9][10][11][12] In this article, we present the second case report of PLC triggered by the Pfizer-BioNTech COVID-19 vaccine. We believe that this case report will reinforce the concept that COVID-19 vaccination could be a possible trigger and should be sought during history taking, especially during this era of COVID-19.…”