2022
DOI: 10.3389/fimmu.2022.887041
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The First Case Report of Preschool-Onset SS/SLE Coexisting With NMOSD of Chinese Origin

Abstract: Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease (CTD), the main features of which are multiple serum autoantibodies and extensive involvement of multiple systems. The onset age of patients varies from childhood to middle age, with nearly 1/5 in childhood. Sjogren’s syndrome (SS) is also an autoimmune disease characterized by high-degree lymphocytic infiltration of exocrine glands, usually occurring in middle-aged and older women, and rarely in childhood. Neuromyelitis optica spect… Show more

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Cited by 2 publications
(1 citation statement)
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“…Notably, 7.7–12% of NMOSD patients also exhibit anti-SSA or anti-SSB antibodies ( 16 ). NMOSD combined with SS often presents with LETM and ON, tends to recur, and is associated with severe nerve damage and poor clinical prognosis ( 17 ). Interestingly, AQP4 expression is low in the salivary glands, while AQP5, which shares approximately 50% protein sequence identity with AQP4, is highly expressed ( 18 ).…”
Section: Discussionmentioning
confidence: 99%
“…Notably, 7.7–12% of NMOSD patients also exhibit anti-SSA or anti-SSB antibodies ( 16 ). NMOSD combined with SS often presents with LETM and ON, tends to recur, and is associated with severe nerve damage and poor clinical prognosis ( 17 ). Interestingly, AQP4 expression is low in the salivary glands, while AQP5, which shares approximately 50% protein sequence identity with AQP4, is highly expressed ( 18 ).…”
Section: Discussionmentioning
confidence: 99%