Simultaneous observations of quasiperiodic (QP) echoes and plasma drift in the ionospheric E region were conducted in Fuke (19.5°N, 109.1°E), Hainan province, China, to investigate the QP striation tilts under varying plasma drift conditions. The E region field‐aligned irregularities (FAIs), observed using the Hainan VHF radar, and the drift velocities of the plasma blobs in the Es layer, recorded by the Hainan Digisonde operating in drift mode, are reported. The QP echoes and drift data recorded during the entire year of 2013 were analyzed and compared. A surprising consistency between the striation tilt of the QP echoes and the drift direction of the plasma blobs was discovered. A negative echo striation of the QP FAIs was recorded when the measured drift direction of the plasma blobs was southward, whereas a positive echo striation was observed during the northward drift. Furthermore, the echo trace was continuous, whereas the QP striation changed from negative to positive, and vice versa. Thus, it can be concluded that the morphology of the QP echoes may be controlled by the background wind fields in the E region. The northward/southward‐drifting striated FAIs in the observation region of a coherent scatter radar might induce the positive/negative QP echo striation in the range‐time‐intensity plots.