The first demonstration that a subset of women with hyperemesis gravidarum has abnormalities in the vestibuloocular reflex pathway

Goodwin, T. Murphy; Nwankwo, Odinaka A.; O'Leary, Linda Davis; O'Leary, Dennis P.; Romero, Roberto; Korst, Lisa M.

doi:10.1016/j.ajog.2008.07.003

Cited by 14 publications

(9 citation statements)

References 24 publications

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“…Some HG patients demonstrated subclinical abnormalities in vestibuloocular reflex also postpartum [27]. This could support the hypothesis of unmasking of subclinical vestibular disorders behind some cases of HG [27,28]. We found association between NVP and both history of motion sickness and seasickness.…”

Section: Discussionsupporting

confidence: 86%

“…However, Whitehead et al and Gadsby et al [25,26] found higher reported frequency of motion sickness in women with NVP. Goodwin et al [27] found in their preliminary study using vestibular autorotation test abnormalities in vestibular system in patients with HG. Some HG patients demonstrated subclinical abnormalities in vestibuloocular reflex also postpartum [27].…”

Section: Discussionmentioning

confidence: 96%

“…Goodwin et al [27] found in their preliminary study using vestibular autorotation test abnormalities in vestibular system in patients with HG. Some HG patients demonstrated subclinical abnormalities in vestibuloocular reflex also postpartum [27]. This could support the hypothesis of unmasking of subclinical vestibular disorders behind some cases of HG [27,28].…”

Section: Discussionmentioning

confidence: 96%

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Nausea and vomiting of pregnancy: associations with personal history of nausea and affected relatives

Laitinen

Nurmi

Ellilä

et al. 2020

Arch Gynecol Obstet

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Purpose To examine whether personal history of nausea or history of nausea and vomiting of pregnancy (NVP) in relatives are risk factors for a woman to suffer from NVP. Further, to evaluate if these factors are associated with the severity of NVP. Methods Cohort study of 2411 pregnant women recruited from maternity health care clinics. The severity of NVP was categorized according to Pregnancy-Unique Quantification of Emesis (PUQE) questionnaire into no/mild/moderate/severe NVP. History of nausea was assessed in connection with motion sickness, seasickness, migraine or other kinds of headache, after anesthesia, related to the use of contraceptives, and other kinds of nausea. History of NVP in relatives was categorized into first-degree (mother/sister) and second-degree relatives (more distant). Results In multivariable analysis including previous personal history of nausea, motion sickness (OR 3.17, 95% CI 1.81-5.56, p < 0.0001) and nausea in migraine (OR 3.18, 95% CI 1.86-5.45, p < 0.0001) were associated with severe NVP. History of nausea in other kinds of headache was associated with moderate NVP (OR 1.91, 95% CI 1.34-2.72, p = 0.001). Women with affected first-degree relatives had higher odds for moderate (OR 3.84, 95% CI 2.72-5.40) and severe (OR 3.19, 95% CI 1.92-5.28) NVP (p < 0.0001). All these results remained significant after adjusting for parity, body mass index, smoking, employment and age. Conclusion Women with personal history of nausea or family history of NVP have an increased susceptibility of NVP. This information is useful in pre-pregnancy counselling.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 96%

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Nausea and vomiting of pregnancy: associations with personal history of nausea and affected relatives

Laitinen

Nurmi

Ellilä

et al. 2020

Arch Gynecol Obstet

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“…This study was part of a larger study investigating the clinical, physiological, and biochemical characteristics of women with HG and a community sample of pregnant women. 13 HG was defined as persistent vomiting unrelated to other causes that required hospitalization for treatment with intravenous fluids or parenteral nutrition. Participants were interviewed during their first trimester of pregnancy.…”

Section: Participants and Proceduresmentioning

confidence: 99%

Evidence Against a Link Between Hyperemesis Gravidarum and Personality Characteristics from an Ethnically Diverse Sample of Pregnant Women: A Pilot Study

D’Orazio

Meyerowitz

Korst

et al. 2011

Journal of Women's Health

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Background: Hyperemesis gravidarum (HG), a pregnancy-related condition marked by extreme nausea and vomiting, has been considered a psychosomatic illness associated with long-standing personality characteristics (e.g., hysteria). In this pilot study, we examined personality, somatic, and psychological variables with ethnically diverse samples of women with HG and women with typical levels of nausea and vomiting of pregnancy (NVP). Methods: Personality (Minnesota Multiphasic Personality Index-2 [MMPI-2] and MMPI-2RF), somatic (MMPI-2RF), and psychological (Beck Depression Inventory-II [BDI-II] and NVP-related quality of life) variables collected during the first trimester of pregnancy were compared between 15 women with HG and 15 women with normal levels of NVP matched for age, education, marital status, insurance source, and race=ethnicity. A secondary analysis was performed comparing these variables among a group of 9 asymptomatic pregnant women to the HG and NVP groups. Results: No significant differences were found between the HG and NVP groups on any personality, somatic, or psychological variables. Both groups had clinically significant elevations on the MMPI-2 hypochondriasis scale, which incorporates somatic symptoms. The NVP group had a clinically significant elevation on the MMPI-2RF gastrointestinal complaints scale. Both groups had significantly higher means on the MMPI-2 and MMPI-2RF scales than the asymptomatic group. Predominantly Spanish speakers appeared particularly vulnerable to psychological distress associated with somatic complaints. Conclusions: The results of this pilot study suggest that research with HG patients is feasible and that psychological distress expressed by women with HG and NVP may reflect reactions to somatic symptoms. No evidence was found to support an association between HG and personality characteristics. Recommendations for future research are provided, such as examining the potential benefits of translation services for Spanishspeaking HG patients.

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“…Currently the cause of nausea and vomiting in pregnancy is unknown although there is strong evidence linking human chorionic gonadotropin or estrogens as well as genetic susceptibility possibly mediated through the vestibuloocular reflex pathway [36,37]. While spontaneous abortion rates may not be significantly different in women with or without HG [38], it can lead to long-term effects on the patient including postpartum post-traumatic stress symptoms and difficulty producing breast milk [39], and recent research suggests it may be linked to permanent neurobehavioral abnormalities in the exposed fetus [40].…”

Section: Commentmentioning

confidence: 99%

Change in paternity and recurrence of hyperemesis gravidarum

Fejzo

Ching

Schoenberg

et al. 2011

The Journal of Maternal-Fetal & Neonatal Medicine

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Objective To determine whether change in paternity changes recurrence risk of hyperemesis gravidarum (HG). Study Design Survey data on recurrence of HG was compared between cases who had a paternity change between pregnancies and cases who did not. Results The percentage of HG pregnancies in women with the same partner for all pregnancies was not significantly different from the percentage of HG pregnancies in women who changed partners for at least one pregnancy (78% vs 71%, p > 0.05). Participants who did and did not change partners between their first and second pregnancies, were asked to rate their first and second pregnancy in regards to symptoms of HG. Neither the ratings nor the change in rating between pregnancies was significantly different between the two groups. Conclusion Women reported HG in over 70% of their pregnancies regardless of paternity change. Paternal genes expressed through the fetus do not have a significant effect on incidence or recurrence of HG. This study supports a strong maternal genetic factor involved in HG. However, because the recurrence risk is not 100%, other factors play a role. Identification of the predisposing gene(s) and other factors will determine the cause of this poorly understood complication of pregnancy.

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The first demonstration that a subset of women with hyperemesis gravidarum has abnormalities in the vestibuloocular reflex pathway

Cited by 14 publications

References 24 publications

Nausea and vomiting of pregnancy: associations with personal history of nausea and affected relatives

Nausea and vomiting of pregnancy: associations with personal history of nausea and affected relatives

Evidence Against a Link Between Hyperemesis Gravidarum and Personality Characteristics from an Ethnically Diverse Sample of Pregnant Women: A Pilot Study

Change in paternity and recurrence of hyperemesis gravidarum

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