The First Documentation of Reproduction in a Genetically Obese Female fa/cp Rat

Abstract

would like to see their future children protected from dread genetic disorders to eugenics, which would involve socially mandated genetic engineering of children. The only way to avoid this moral slide is to forbid the development of the technology from the beginning.In the final analysis I find all of these objections less than compelling because there are competing moral considerations that weaken their moral force. I conclude that germline genetic engineering should go forward, though we may discover as the technology unfolds that there are specific applications of it that are morally objectionable. Animal Models

Obesity Genes and Insulin Resistance Syndrome

“…The f mutation arose spontaneously in Koletsky's hypertensive rat strain 6 and the mutation was introgressed into the LA/N and SHR/N strains developed at the NIH by Hansen 44 . In complementation studies, we have produced obese, apparent 13M‐LA/N fa / f compound mutants, 49 confirming Yen's earlier findings with Zucker‐Koletsky fa / f compound mutants 50 . Recently, in genetic mapping studies, we have placed the f gene in an interval between ( Pgml ) and ( Glutl ) on rat chromosome (Chr) 5, 51 which also contains fa 19,52 .…”

“…In this review, subsequent reference to f or cp will be made as fa k (“ corpulent ”). Based on three pieces of evidence, namely, the production of fa / f compound mutants, 49,50 mutation sequencing identification, and molecular mapping, 51 it is now clear that fa and f are mutations in the same gene, the leptin receptor ( Lepr ) 21,25,26,29,30 . The Koletsky mutation is due to a Tyr763Stop mutation in the leptin receptor 53,54 .…”