The First European Evidence-based Consensus on Extra-intestinal Manifestations in Inflammatory Bowel Disease

Harbord, Marcus; Annese, Vito; Vavricka, Stephan R.; Allez, Matthieu; Acosta, Manuel Barreiro‐de; Boberg, Kirsten Muri; Burisch, Johan; Vos, Martine De; Vries, Annemarie de; Dick, Andrew D.; Juillerat, Pascal; Karlsen, Tom H.; Koutroubakis, Ioannis Ε.; Lakatos, László; Orchard, Tim; Papay, Pavol; Raine, Tim; Reinshagen, Max; Thaçi, Diamant; Tilg, Herbert; Carbonnel, Franck

doi:10.1093/ecco-jcc/jjv213

Cited by 678 publications

(784 citation statements)

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“…These findings were confirmed in several studies performed by independent groups, in meta-analyses performed by our group [13][14][15], and in a meta-analysis performed by an independent group that, methodologic issues aside [16], has also reported both increased intima-media thickness and reduced flow-mediated dilation in patients with IBD [17]. These findings, coupled to the elevated risk of coronary heart disease and cerebrovascular accident reported in patients with IBD [18], help to explain the IBD paradox: increased cardiovascular risk with a low prevalence of classic cardiovascular risk factors [19].…”

Section: Introductionsupporting

confidence: 81%

Pulse wave velocity differs between ulcerative colitis and chronic kidney disease

Zanoli

Lentini

Boutouyrie

et al. 2018

European Journal of Internal Medicine

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Section: Introductionsupporting

confidence: 81%

Pulse wave velocity differs between ulcerative colitis and chronic kidney disease

Zanoli

Lentini

Boutouyrie

et al. 2018

European Journal of Internal Medicine

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“…Our finding demonstrating an association between hypergammaglobulinemia and corticosteroid induction and early maintenance with immunomodulators is plausibly attributed to the fact that patients with either EIMs or pancolitis are usually more aggressively treated during both induction and maintenance (9,11).…”

Section: Matar Et Al Igg In Pediatric Ibdmentioning

confidence: 73%

Hypergammaglobulinemia is a marker of extraintestinal manifestations in pediatric inflammatory bowel disease

Matar¹,

Rinawi²,

Shamir³

et al. 2017

Turk J Gastroenterol

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“…14,15 Moreover, hospitalized IBD patients have higher rates of VTE than non-IBD hospitalized patients. 6,14,[16][17][18][19][20] The well-established, non-specific acquired VTE risk factors (e.g. smoking, oral contraceptives, immobilization, central venous catheters, pregnancy and dehydration) might also provoke the development of VTE in IBD patients.…”

Section: Introductionmentioning

confidence: 99%

Steroid but not Biological Therapy Elevates the risk of Venous Thromboembolic Events in Inflammatory Bowel Disease: A Meta-Analysis

Patrícia

Szemes

Hegyi

et al. 2017

Journal of Crohn's and Colitis

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Background and Aims: Inflammatory bowel disease [IBD] is associated with a 1.5-to 3-fold increased risk of venous thromboembolism [VTE] events. The aim of this study was to determine the risk of VTE in IBD as a complication of systemic corticosteroids and anti-tumour necrosis factor alpha [TNFα] therapies. Methods: A systematic review and meta-analysis was conducted, which conforms to the Preferred Reporting Items for Systematic Reviews and Meta-analyses [PRISMA] statement. PubMed, EMBASE, Cochrane Library and Web of Science were searched for English-language studies published from inception inclusive of 15 April 2017. The population-intervention-comparisonoutcome [PICO] format and statistically the random-effects and fixed-effect models were used to compare VTE risk during steroid and anti-TNFα treatment. Quality of the included studies was assessed using the Newcastle-Ottawa scale. The PROSPERO registration number is 42017070084. Results: We identified 817 records, of which eight observational studies, involving 58 518 IBD patients, were eligible for quantitative synthesis. In total, 3260 thromboembolic events occurred. Systemic corticosteroids were associated with a significantly higher rate of VTE complication in IBD patients as compared to IBD patients without steroid medication (odds ratio [OR]: 2.202; 95% confidence interval [CI]: 1.698-2.856, p < 0.001). In contrast, treatment with anti-TNFα agents resulted in a 5-fold decreased risk of VTE compared to steroid medication [OR: 0.267; 95% CI: 0.106-0.674, p = 0.005]. Conclusion: VTE risk should be carefully assessed and considered when deciding between anti-TNFα and steroids in the management of severe flare-ups. Thromboprophylaxis guidelines should be followed, no matter the therapy choice.

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The First European Evidence-based Consensus on Extra-intestinal Manifestations in Inflammatory Bowel Disease

Cited by 678 publications

References 0 publications

Pulse wave velocity differs between ulcerative colitis and chronic kidney disease

Pulse wave velocity differs between ulcerative colitis and chronic kidney disease

Hypergammaglobulinemia is a marker of extraintestinal manifestations in pediatric inflammatory bowel disease

Steroid but not Biological Therapy Elevates the risk of Venous Thromboembolic Events in Inflammatory Bowel Disease: A Meta-Analysis

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