The first evaluation of the effectiveness of canine vaccination schedule by two commercial vaccines in Iran

Abstract

Background Canine Parvovirus type 2 (CPV-2) is a member of the Parvoviridae family with a global distribution and causes pathogenicity in puppies aged from 6 weeks to 6 months. It should be noted that Maternally Derived Antibodies (MDA) have protection against CPV-2 in the first weeks of puppies’ life. However, MDA declines with age. The most important influential factor is timely vaccination against CPV-2. Methods In this study, 24 healthy 8-week-old terrier puppies were selected and divided into three identical groups based on a randomized, double-blind comparative trial. One of which was called the control group that was injected with the physiological serum. The second group was the group A that was vaccinated by the vaccine provided by Biocan DHPPi+L (Bioveta, Czech). The third group was group B that was vaccinated by the vaccine of Duramune Max 5 + LCI / GP (Fort Dodge Animal Health, USA) from 8 to 16 weeks of their life at every 4 weeks. Then serum samples were analyzed with HI and ELISA tests. Results The MDA titer was protective in some puppies until 18 weeks of age. Also, after the first vaccination, all puppies had a protective titer against CPV-2, and Duramune vaccine had seroconverted after the first injection and Biocan had seroconverted after the second injection. Conclusions It is recommended that to reduce the risk of vaccine failure: such as the MDA titer should be measured in puppies before designing a vaccination schedule.

Epidemiological and Molecular Approaches for a Fatal Feline Panleukopenia Virus Infection of Captive Siberian Tigers (Panthera tigris altaica) in the Republic of Korea

“…One of them even died, which suggested that their vaccine-induced immunity was not sufficient to fully protect them against FPV at the time of infection. To understand the reason why the tiger cubs were not protected from FPV infection despite vaccination, we concentrated on the host-related vaccine failure induced by MDA, which is well documented in young animals and has been recognized as one of the most common reasons for vaccine failure in cats and dogs [ 45 , 46 , 47 , 48 ]. According to this hypothesis, kittens that receive high levels of MDA may fail to respond to a final dose of the FPV vaccine at 16 weeks of age.…”

Prophylaxe der kaninen Parvovirose

“…Lebenswoche hinaus (bis zur 18. Lebenswoche) persistieren und mit der Impfung interferieren können 62 , 63 , 64 . Von einigen Autoren wird daher angeregt, Welpen-Impfungen, bis zur 20.…”

Canine Parvovirus Infection in Dogs: Pathogenesis, Clinical Symptoms, Diagnosis, Prevalence, Therapy, and Vaccination

“…Anjing harus menerima booster dalam waktu 1 tahun setelah vaksinasi utama diberikan atau kapan saja antara 26 dan 52 minggu. Vaksinasi diberikan dengan interval 3 tahun atau lebih(Decaroa et al, 2020).Gambar 1 menunjukkan hasil penelitian yang dilakukanShams et al, (2022), melihat titer antibodi 24 anak anjing terrier (12 ekor jantan dan 12 ekor betina) yang dibagi menjadi kelompok A, B, dan C. Kelompok A disuntikkan 1 ml normal saline, kelompok B disuntikkan vaksin Biocan DHPPi+L Bioveta, Czech, dan kelompok C disuntikkan vaksin Duramune Max 5+LCI/GP; Fort Dodge Animal Health, USA. Hasil penelitian ini membuktikan bahwa pada vaksinasi pertama, kelompok B telah menghasilkan antibodi sedangkan kelompok A menghasilkan antibodi pada vaksinasi kedua.…”