The first evidence of four transcripts from two Interleukin 18 genes in animal and their involvement in immune responses in the largest amphibian Andrias davidianus

Wang, Lan Zhi; Xu, Ya Ping; Zhou, Yi; Liu, Ze Peng; Li, Bo; Gu, Wen Bin; Zhao, Xiangfu; Wang, Dong; Miao, Shuying

doi:10.1016/j.dci.2019.103598

Cited by 5 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The bony fish-specific TLR21 and 22 genes and the mouse-specific TLR13 gene orthologs are present in A. davidianus, while AdTLR2, AdTLR5, and AdTLR21 have duplicated gene copies (17). Genes encoding the downstream molecules of TLR signaling pathway including the adapter MyD88 and the pro-inflammatory cytokines such as TNFa, IL-1b, IFNg, IL-6, and IL-18, have also been identified in A. davidianus (4,17,27). AdTLRs are less diversified than fish and X. laevis although some TLRs and the downstream pathways are conserved.…”

Section: Innate Immune Systemmentioning

confidence: 99%

The Immune System and the Antiviral Responses in Chinese Giant Salamander, Andrias davidianus

et al. 2021

View full text Add to dashboard Cite

The Chinese giant salamander, belonging to an ancient amphibian lineage, is the largest amphibian existing in the world, and is also an important animal for artificial cultivation in China. However, some aspects of the innate and adaptive immune system of the Chinese giant salamander are still unknown. The Chinese giant salamander iridovirus (GSIV), a member of the Ranavirus genus (family Iridoviridae), is a prominent pathogen causing high mortality and severe economic losses in Chinese giant salamander aquaculture. As a serious threat to amphibians worldwide, the etiology of ranaviruses has been mainly studied in model organisms, such as the Ambystoma tigrinum and Xenopus. Nevertheless, the immunity to ranavirus in Chinese giant salamander is distinct from other amphibians and less known. We review the unique immune system and antiviral responses of the Chinese giant salamander, in order to establish effective management of virus disease in Chinese giant salamander artificial cultivation.

show abstract

Section: Innate Immune Systemmentioning

confidence: 99%

The Immune System and the Antiviral Responses in Chinese Giant Salamander, Andrias davidianus

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Thus, there are systemic manifestations (syndromes) of toxic action of cytokines – the syndrome of “leakage of capillaries”, syndrome of septic shock, and others. They are accompanied by impaired microcirculation, pronounced vasodilation, venous overflow, increased vascular wall permeability, and edema, hypovolemia, tissue hypoxia, decreased blood pressure, fever, or metabolic acidosis [ 9 - 10 ]. Under certain conditions, these changes translate into sepsis, septic shock, and irreversible multiple organ failure.…”

Section: Introductionmentioning

confidence: 99%

Dynamics of Cytokine Profile Indicators Changes in Animals with Acute Generalized Peritonitis on the Background of Diabetes Mellitus

et al. 2020

View full text Add to dashboard Cite

In acute peritonitis, any surgical intervention leads to impaired immune protection with the development of postoperative purulent-septic complications, which increases several times the likelihood of death, especially in people with secondary immunodeficiency as a consequence diabetes mellitus. We aimed to study the dynamics of pro- and anti-inflammatory cytokine content in rat serum under experimental acute generalized peritonitis on the background of diabetes mellitus. Fifty-six white rats were used for the study. The determination of the serum cytokine profile was performed by enzyme-linked immunosorbent assay. When comparing the levels of interleukins between the study groups, a statistically significant increase in the level of proinflammatory cytokines was found in the group of diabetic animals during all experimental periods. In particular, the concentration of interleukin – 1β increased significantly by 94% on day 1 of observation, by 115% on day 3, and by 121% on day 7 compared to the control group. Similarly, a significant increase in TNF-α levels was observed in animals with diabetes. In this group, the most significant increase in the level of TNF-α was recorded on the seventh day of the experiment, and it increased by 3.4 times. Animals with acute peritonitis on the background of diabetes had a significantly increased concentration of anti-inflammatory cytokines in the serum of all study groups, which confirms their involvement in the pathogenesis of the disease under study.

show abstract

Immune Defenses Against Ranavirus Infections

Grayfer,

Edholm,

Chinchar

et al. 2024

Ranaviruses

View full text Add to dashboard Cite

Ranaviruses (RV, family Iridoviridae) infect fish, amphibians, and reptiles, raising considerable ecological and commercial concerns due to the escalating infection prevalence and the resulting die-offs of wild and aquacultural species. Notably, ranaviruses exhibit uncanny capacities to cross host species barriers, likely owing to their potent immune evasion mechanisms. In turn, the species infected by these pathogens possess immune systems that are less well understood than those of mammals and often encode unique antiviral genes or multiple orthologs of single hallmark mammalian immune factors. Thus, garnering insight into ranavirus infection strategies is largely contingent on gaining greater understanding of host immune barriers faced by these emerging infectious agents. Accordingly, here we coalesce and update the current state of understanding of the distinct facets of ectothermic vertebrate immune responses to ranaviral infections and underline the most current perspectives of the evasion strategies by which these pathogens circumvent host defenses.

show abstract

The first evidence of four transcripts from two Interleukin 18 genes in animal and their involvement in immune responses in the largest amphibian Andrias davidianus

Cited by 5 publications

References 29 publications

The Immune System and the Antiviral Responses in Chinese Giant Salamander, Andrias davidianus

The Immune System and the Antiviral Responses in Chinese Giant Salamander, Andrias davidianus

Dynamics of Cytokine Profile Indicators Changes in Animals with Acute Generalized Peritonitis on the Background of Diabetes Mellitus

Immune Defenses Against Ranavirus Infections

Contact Info

Product

Resources

About