The First Identification and Retrospective Study of Severe Fever With Thrombocytopenia Syndrome in Japan

Takahashi, Toru; Maeda, Ken; Suzuki, Tadaki; Ishido, Aki; Shigeoka, Toru; Tominaga, Takayuki; Kamei, Toshiaki; Honda, Masahiro; Ninomiya, Daisuke; Sakai, Takenori; Senba, Takanori; Kaneyuki, Shozo; Sakaguchi, Shota; Satoh, Akira; Hosokawa, Takanori; Kawabe, Yojiro; Kurihara, Shintaro; Izumikawa, Koichi; Kohno, Shigeru; Azuma, Taichi; Suemori, Koichiro; Yasukawa, Masaki; Mizutani, Tetsuya; Omatsu, Tsutomu; Katayama, Yukie; Miyahara, Masaharu; Ijuin, Masahito; Doi, Kazuko; Okuda, Masaru; Umeki, Kazunori; Saito, Tomoya; Fukushima, Kazuko; Nakajima, Kensuke; Yoshikawa, Tomoki; Tani, Hideki; Fukushi, Shuetsu; Fukuma, Aiko; Ogata, Momoko; Shimojima, Masayuki; Nakajima, N.; Nagata, Noriyo; Katano, Harutaka; Fukumoto, Hiroki; Sato, Yuko; Hasegawa, Hideki; Yamagishi, Takashi; Oishi, Kazunori; Kurane, Ichiro; Morikawa, Shigeru; Saijo, Masayuki

doi:10.1093/infdis/jit603

Cited by 745 publications

(645 citation statements)

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“…To the authors' knowledge, there are only 2 reports in the literature of ulcerative lesions found in a patient with SFTS, including the previous study describing imaging findings of ulcerative lesions via postmortem pathological examination (3), with the present study being the first report to describe real-time imaging of ulcerative lesions with continuously oozing hemorrhage detected through GI endoscopic examination.…”

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confidence: 81%

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Ulcerative Lesions with Hemorrhage in a Patient with Severe Fever with Thrombocytopenia Syndrome Observed via Upper Gastrointestinal Endoscopy

Kaneyuki¹,

Yoshikawa

Tani

et al. 2016

Jpn J Infect Dis

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SUMMARY: Severe fever with thrombocytopenia syndrome (SFTS) is a novel bunyavirus infection caused by the SFTS virus (SFTSV, family Bunyaviridae, genus Phlebovirus) with a high case fatality rate. A previously healthy 72-year-old man showed symptoms of fever, general fatigue, and altered consciousness. He was hospitalized for treatment. On day 3, considering the day on which fever appeared first during the disease course as day 0, he had bloody emesis. An emergency upper gastrointestinal endoscopic examination revealed multiple ulcerative lesions with continuously oozing hemorrhage in the stomach. He died on day 7. He was retrospectively diagnosed as having SFTS, Although it was less likely that the gastric ulcerative lesions were directly induced by SFTSV replication, it was evident that hemorrhagic emesis might occur in the patient in association with the pathophysiology of SFTS. The real-time imaging of gastric ulcerative lesions in a patient with SFTS is reported.

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confidence: 81%

“…This disease was first reported to be endemic to China in 2011 (1,2), and later reported to be endemic to Japan and South Korea (3,4). Hemorrhagic symptoms such as gingival oozing, bloody diarrhea, and hematuria are commonly observed in patients with severe and fatal SFTS (3,5,6).…”

mentioning

confidence: 99%

Ulcerative Lesions with Hemorrhage in a Patient with Severe Fever with Thrombocytopenia Syndrome Observed via Upper Gastrointestinal Endoscopy

Kaneyuki¹,

Yoshikawa

Tani

et al. 2016

Jpn J Infect Dis

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“…Although the majority of patients are farmers who live in wooded upland areas and work in the fields, a few clusters of cases and human-to-human transmission through direct contact with blood or respiratory secretions have also been reported (Bao et al, 2011;Gai et al, 2012). Human infection of SFTSV has been identified retrospectively in Korea and Japan (Kim et al, 2013;Takahashi et al, 2014). SFTSV and related viruses have also been isolated in ticks collected in Korea and Australia Yun et al, 2014).…”

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confidence: 99%

Suppression of type I and type III IFN signalling by NSs protein of severe fever with thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation

Chaudhary

Zhang

Yuen

et al. 2015

Journal of General Virology

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Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne pathogen causing significant morbidity and mortality in Asia. NSs protein of SFTSV is known to perturb type I IFN induction and signalling, but the mechanism remains to be fully understood. Here, we showed the suppression of both type I and type III IFN signalling by SFTSV NSs protein is mediated through inhibition of STAT1 phosphorylation and activation. Infection with live SFTSV or expression of NSs potently suppressed IFN-stimulated genes but not NFkB activation. NSs was capable of counteracting the activity of IFN-a1, IFN-b, IFN-l1 and IFN-l2. Mechanistically, NSs associated with STAT1 and STAT2, mitigated IFN-b-induced phosphorylation of STAT1 at S727, and reduced the expression and activity of STAT1 protein in IFN-b-treated cells, resulting in the inhibition of STAT1 and STAT2 recruitment to IFNstimulated promoters. Taken together, SFTSV NSs protein is an IFN antagonist that suppresses phosphorylation and activation of STAT1.

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“…Since then, SFTS cases have been reported in many countries, like South Korea, Japan, and the US (3)(4)(5). Prior to 2013, there were as many as 10,000 SFTS cases worldwide (6).…”

Section: Introductionmentioning

confidence: 99%

The effects of health education and promotion with regard to severe fever with thrombocytopenia syndrome (SFTS) in rural residents: A pilot study in China

Guo

et al. 2017

BST

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The First Identification and Retrospective Study of Severe Fever With Thrombocytopenia Syndrome in Japan

Abstract: SFTS has been endemic to Japan, and SFTSV has been circulating naturally within the country.

Cited by 745 publications

References 24 publications

Ulcerative Lesions with Hemorrhage in a Patient with Severe Fever with Thrombocytopenia Syndrome Observed via Upper Gastrointestinal Endoscopy

Ulcerative Lesions with Hemorrhage in a Patient with Severe Fever with Thrombocytopenia Syndrome Observed via Upper Gastrointestinal Endoscopy

Suppression of type I and type III IFN signalling by NSs protein of severe fever with thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation

The effects of health education and promotion with regard to severe fever with thrombocytopenia syndrome (SFTS) in rural residents: A pilot study in China

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