The First International Consensus on Mucous Membrane Pemphigoid

Chan, Lawrence S.; Ahmed, A. Razzaque; Anhalt, Grant J.; Bernauer, Wolfgang; Cooper, Kevin D.; Elder, Mark; Fine, Jo David; Foster, C. Stephen; Ghohestani, Reza F.; Hashimoto, Takashi; Hoang–Xuan, T.; Kirtschig, Gudula; Korman, Neil J.; Lightman, Susan; Lozada‐Nur, Francina; Marinkovich, M. Peter; Mondino, Bartly J.; Prost-Squarcioni, Catherine; Rogers, Roy S.; Setterfield, Jane; West, Dennis P.; Wojnarowska, Fenella; Woodley, David T.; Yancey, Kim B.; Zillikens, Detlef; Zone, John J.

doi:10.1001/archderm.138.3.370

Cited by 648 publications

(308 citation statements)

References 88 publications

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“…24% of patients with MMP have skin involvement, and 4% have esophageal involvement [5]. Scarring is one of the distinguishing features between MMP and BP as BP bullae do not leave scars, whereas MMP does [6]. In this paper we report a case of esophageal BP including an esophageal stricture.…”

Section: Introductionmentioning

confidence: 83%

“…MMP usually involves oral mucosal involvement and causes scarring. Antigens identified in MMP include BP180, BP230, Laminin 5/6, Type VII collagen, and Integrin 4 subunit [6], whereas BP involves BP180 and BP230. It is important to differentiate esophageal BP from MMP as the approach to treatment can differ.…”

Section: Discussionmentioning

confidence: 99%

“…The approach to treatment of a patient with BP generally progresses from topical steroids, to systemic steroids to immunosuppression depending on the severity of the disease. However, a patient with extraoral MMP is treated more aggressively as the bullae cause scarring and systemic therapy is used initially regardless of the severity of the disease [6].…”

Section: Discussionmentioning

confidence: 99%

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Esophageal Manifestations of Bullous Pemphigoid

Kwapisz¹

2017

GHOA

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We report the case of an 86-year old female who presented with dysphagia, nausea and epigastric tenderness. She had a history of bullous pemphigoid treated with high dose steroids and immunosuppression. She was in the process of tapering her steroids following a bullous pemphigoid flare when these symptoms developed; she did not have any skin involvement at the time of presentation. She underwent endoscopy to investigate these symptoms, which showed desquamative mucosa and a trapped food bolus. An iatrogenic tear was caused in attempting to bypass the food bolus. Endoscopy was repeated in the operation room and a stricture was found at the site where a food bolus was previously seen. She was put back on high dose steroids and the stricture was dilated leading to resolution of her symptoms. Esophageal involvement of bullous pemphigoid is rare, and usually manifests as hemorrhagic bullae. An esophageal stricture resulting from bullous pemphigoid has not yet been reported. Keywords:

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Section: Introductionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Esophageal Manifestations of Bullous Pemphigoid

Kwapisz¹

2017

GHOA

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“…It is characterised by bullous eruptions and ulceration, particularly of the oral mucosa and conjunctiva. 11 Eighty percent of the affected patients have oral lesions in the form of shallow ulcerations and a characteristic form of gingivitis known as desquamative gingivitis (see Figure 7). Seventy percent may have conjunctival lesions, 25% have genital lesions, and 20% have skin lesions.…”

Section: Diagnosismentioning

confidence: 99%

Diagnosis and management of common non-viral oral ulcerations

Heerden

2007

South African Family Practice

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SA Fam Pract 2007;49(8): 20-26 CPD ArticleOral ulcerations are common lesions encountered in private practice. Oral ulcers can have a localised aetiology or be a manifestation of a variety of systemic conditions or disorders. Appropriate management depends on the correct diagnosis which can at times be difficult due to similar clinical features. The aetiology, diagnosis and management of the most common non-viral ulcerative disorders of the oral mucosa are discussed. These include traumatic ulcers, recurrent aphthous stomatitis, malignancy as well as oral ulceration associated with cutaneous pathology.

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“…Management of gingival lesions of vesicobullous autoimmune diseases is one the main challenges to oral medicine, primarily because of their chronic nature. [1][2][3] Treatment of these lesions usually requires topical corticosteroids, or other anti-inflammatory drugs. Systemic therapy is required in most severe lesions, especially in pemphigus.…”

mentioning

confidence: 99%

Corticosteróide tópico oclusivo no tratamento de manifestações gengivais de doenças vesicobolhosas auto-imunes

Motta

Komesu

Grisi

et al. 2006

An. Bras. Dermatol.

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Management of gingival lesions of vesicobullous autoimmune diseases is one the main challenges to oral medicine, primarily because of their chronic nature. Systemic therapy is required in most severe lesions, however, whenever feasible, topic corticosteroid therapy is preferred. This article describes a technique to provide topical occlusive corticotherapy that has shown to be effective in controlling these lesions, especially in patients exclusively with gingival lesions. Keywords: Adrenal cortex hormones; Autoimmune diseases; Gingiva; Oral manifestations; Skin diseases, vesiculobullous Resumo: O tratamento das lesões gengivais de doenças vesicobolhosas auto-imunes constitui grande desafio na estomatologia, principalmente pela natureza crônica das lesões. O tratamento sistêmico é necessário no controle das apresentações mais graves

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The First International Consensus on Mucous Membrane Pemphigoid

Cited by 648 publications

References 88 publications

Esophageal Manifestations of Bullous Pemphigoid

Esophageal Manifestations of Bullous Pemphigoid

Diagnosis and management of common non-viral oral ulcerations

Corticosteróide tópico oclusivo no tratamento de manifestações gengivais de doenças vesicobolhosas auto-imunes

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