The first isolation of Nocardia nova from an HIV-1 infected individual in Japan

Koibuchi, Tomohiko; Takahashi, Takashi; Nakamura, Toshio; Suzuki, Masato; Minamoto, Fujihiko; Oyaizu, Naoki; Yazawa, Kazunaga; Mikami, Yuzuru; Iwamoto, Aikichi

doi:10.1007/s10156-002-0189-3

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…Nocardial infection in patients with an advanced stage of HIV infection is associated with high mortality (38.7%) [19,23] and successful treatment depends on early recognition of the nocardial infection and the initiation of specific treatment. The diagnosis of nocardiosis is frequently delayed or missed because of its nonspecific clinical manifestations [6,14] and the slow growth of the bacilli [1,13,19,24].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary nocardiosis caused by Nocardia exalbida complicating Pneumocystis pneumonia in an HIV-infected patient

Imai

Koibuchi

Kimura

et al. 2011

Journal of Infection and Chemotherapy

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Section: Discussionmentioning

confidence: 99%

Pulmonary nocardiosis caused by Nocardia exalbida complicating Pneumocystis pneumonia in an HIV-infected patient

Imai

Koibuchi

Kimura

et al. 2011

Journal of Infection and Chemotherapy

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Brain abscess caused by Nocardia nova

Hashimoto

Johkura

Ichikawa

et al. 2008

Journal of Clinical Neuroscience

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Pneumocystis jirovecii and Nocardia pneumonia in a middle-aged male with Nephrotic syndrome: a case report and literature review

Wang,

He,

Liu

et al. 2024

BMC Infect Dis

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Introduction Nephrotic syndrome (NS) is a common chronic kidney disease that is often accompanied by a state of immunodeficiency. Immunosuppression increases the risk of infections, with Pneumocystis jirovecii and Nocardia brasiliensis being two opportunistic pathogens that can cause severe infections in patients with compromised immune function. This study presents a case of a middle-aged male patient with NS concurrently infected with Pneumocystis jirovecii and Nocardia brasiliensis. It aims to synthesize the pertinent diagnostic approaches and treatment experiences. Notably, there have been no reported cases of NS occurring simultaneously with both Pneumocystis jirovecii pneumonia and Nocardia pneumonia. Case presentation A 58-year-old male farmer presented to the hospital with a one-week history of persistent fever, cough, and sputum production. His maximum body temperature was recorded at 39 °C, and he produced yellow viscous sputum. This patient had a one-year history of NS, managed with long-term oral corticosteroid and cyclophosphamide therapy. Admission chest computed tomography displayed interstitial changes in both lungs. After failing to detect any pathogens through routine etiological tests, we successfully identified Nocardia brasiliensis, Pneumocystis jirovecii, and Lodderomyces elongisporus using bronchoscopy-guided sputum samples through metagenomic next-generation sequencing (mNGS) technology. Subsequently, we initiated a combined treatment regimen for the patient using trimethoprim-sulfamethoxazole, meropenem, and moxifloxacin, which yielded remarkable therapeutic outcomes. Conclusion The adoption and promotion of mNGS technologies have significantly resolved the difficulty in early pathogen detection, guiding clinicians from empirical to genomic diagnosis, achieving prevention before treatment, and thereby enhancing patient survival rates.

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The first isolation of Nocardia nova from an HIV-1 infected individual in Japan

Cited by 3 publications

References 6 publications

Pulmonary nocardiosis caused by Nocardia exalbida complicating Pneumocystis pneumonia in an HIV-infected patient

Pulmonary nocardiosis caused by Nocardia exalbida complicating Pneumocystis pneumonia in an HIV-infected patient

Brain abscess caused by Nocardia nova

Pneumocystis jirovecii and Nocardia pneumonia in a middle-aged male with Nephrotic syndrome: a case report and literature review

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