The First Non-Typeable Haemophilus Influenzae Osteomyelitis and Discitis of the Cervical Vertebrae in an Adult: A Case Report and Systematic Review of Literature

Fong, Jing Hong; Menon, Shalisha Joy; Jones, Gareth Iestyn Robert; Karunaratne, Hettiyadura  Apsara Surangani

doi:10.2139/ssrn.4279144

Cited by 1 publication

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“…Although a known cause of osteomyelitis in children, H. influenzae is a rare cause of osteomyelitis in adults 2 . Haemophilus influenzae is a nonmotile Gram-negative Bacillus associated with uncomplicated nasopharynx infections 7,9 . It can also be the causative agent for severe infection such as pneumonia, bacteremia, and meningitis 4 .…”

Section: Discussionmentioning

confidence: 99%

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Culture-Negative Osteomyelitis: Is it Haemophilus haemolyticus?

Hull,

Balsamo

2024

JBJS Journal of Orthopaedics for Physician Assistants

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Case: A 50-year-old woman presented to our emergency department with severe intractable atraumatic right hip pain. She was admitted to the hospital, and an orthopaedic consult was requested. She does have a known history of right hip osteoarthritis, but does not actively follow with an orthopaedic surgeon. Advanced imaging was obtained followed by computed tomography–guided biopsy of the right hip to include cartilage and bone. The cultures were negative for growth. An incision and debridement were performed, and necrotic bone was found. Subsequently, an antibiotic spacer was placed secondary to osteomyelitis. Blood cultures and tissue polymerase chain reaction 16S ribosomal RNA were positive for Haemophilus haemolyticus. Discussion: Culture-negative osteomyelitis remains a treatment challenge. Several organisms have the potential to cause osteomyelitis. Unfortunately, a high percentage of patients have fallen into the category of culture-negative disease. This is a case report discussing an immunocompetent patient with a rarely reported cause of osteomyelitis and how to assist with definitive diagnosis of culture-negative cases.

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Section: Discussionmentioning

confidence: 99%

“…In this state, bacterial pathogens can remain metabolically active but will not grow in common culture media 6 . PCR 16S rRNA can still identify organisms in VBNC state 7 . This accurately identified the pathogen in our case report as H. haemolyticus .…”

Section: Discussionmentioning

confidence: 99%

Culture-Negative Osteomyelitis: Is it Haemophilus haemolyticus?

Hull,

Balsamo

2024

JBJS Journal of Orthopaedics for Physician Assistants

View full text Add to dashboard Cite

show abstract

The First Non-Typeable Haemophilus Influenzae Osteomyelitis and Discitis of the Cervical Vertebrae in an Adult: A Case Report and Systematic Review of Literature

Cited by 1 publication

References 0 publications

Culture-Negative Osteomyelitis: Is it Haemophilus haemolyticus?

Culture-Negative Osteomyelitis: Is it Haemophilus haemolyticus?

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