The First Orthotopic Ovarian Transplant in Turners Syndrome

Mhatre, Pravin; Mhatre, Jyoti

doi:10.1097/00007890-200407271-01212

Cited by 5 publications

(7 citation statements)

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“…Transplant of the ovary and/or fallopian tube or of the uterus, with the objective of re-establishing fertility and/or ovarian endocrine function, has been achieved in different species such as guinea pig, hamster, rat, rabbit, dog, sheep, pig, primate, and in women, with varying results (14)(15)(16)(17)(18)(19)(21)(22)(23)(24)(25)(26)(27)(28). In women, fallopian tube transplant has been performed unsuccessfully in 21 cases with the objective of re-establishing fertility.…”

Section: Discussionmentioning

confidence: 99%

Restoration of Endocrine Function and Fertility with Orthotopic Tubal—Ovarian Allotransplant as the Anatomical-Functional Unit in Rabbits

Meraz

Juárez

Revilla-Monsalve

et al. 2008

Journal of Investigative Surgery

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The aim of this study was to re-establish endocrine and reproductive function in tubal-ovariectomized rabbits using orthotopic tubal-ovary allotransplants (OT-OA). Fifty-five New Zealand White nonconsanguineous rabbits were used and allocated into five experimental groups: Each group comprised donors submitted to right salpingo-oophorectomy that served as the donated allograft. In group 1 no cyclosporin (CsA) was administered and rabbits were submitted to left salpingo-oophorectomy (LSO). Group 2 was the allotransplant group and did not receive CsA. Group 3 was the allotransplant group with CsA. They were submitted to bilateral salpingo-oophorectomy followed by OT-OA. CsA of 10 mg/kg/day was administered to rabbits for the first 21 days and 5 mg/kg/day for the remainder of the study. Group 4 received CsA just as for group 3 and was submitted to LSO. During the study the following were measured: estradiol (E2), progesterone (P4), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and histopathological study of the uteri, tubes, and ovaries. Groups 1, 3, and 4 showed a significant increase in serum E2 and P4 levels corresponding to the second week of gestation, compared to group 2 (p < .05). Group 2 showed a significant increase in serum LH and FSH levels during week 10 compared to serum LH and FSH levels in groups 1, 3, and 4 (p < .05). In group 3, three rabbits did not reject the allotransplant, one rabbit became pregnant, and endocrine function was re-established in two rabbits. It can be concluded that OT-OA together with CsA administration re-establishes endocrine function and fertility.

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Section: Discussionmentioning

confidence: 99%

Restoration of Endocrine Function and Fertility with Orthotopic Tubal—Ovarian Allotransplant as the Anatomical-Functional Unit in Rabbits

Meraz

Juárez

Revilla-Monsalve

et al. 2008

Journal of Investigative Surgery

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“…Third, the patient may be administered human recombinant erythropoietin during and after the surgery to increase (Elliott, Butler et al, ). Additionally, potential vessels for anastomosis can be identified and utilised as in the case of an entire ovary transplantation graft (Mhatre & Mhatre, ; Mhatre, Mhatre, Modi, & Doshi, ; Raya‐Rivera, Esquiliano, Yoo et al, ; Raya‐Rivera, Esquiliano, Fierro‐Pastrana et al, ). Taken together, effective neovascularisation should be achieved through anastomosis or through the addition of angiogenic factors and presurgical procedures.…”

Section: Transplantation Sites and Surgical Considerationsmentioning

confidence: 99%

“…Donor ovarian artery to recipient inferior epigastric artery, donor ovarian vein to recipient external iliac vein (Mhatre & Mhatre, ; Mhatre et al, )…”

Section: Transplantation Sites and Surgical Considerationsmentioning

confidence: 99%

“…When the artificial ovary is to be applied in a clinical setting (Table ), the transplanted graft may be followed up and evaluated by observing inflammatory immune responses (e.g., C‐reactive protein level and CD4/WBC count), measuring the serum hormone level, following the menstrual cycle, and imaging follicles via ultrasonographic evaluation (J. Donnez et al, ; J. Donnez, Martinez‐Madrid et al, ; Meirow et al, ; Mhatre & Mhatre, ; Mhatre et al, ; Povoa et al, ; Silber et al, ). Moreover, it is important to confirm that genetic information of oocytes within follicles is not altered during the FP process.…”

Section: Evaluation and Monitoringmentioning

confidence: 99%

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A new possibility in fertility preservation: The artificial ovary

Cho

Kim

Noh

et al. 2019

J Tissue Eng Regen Med

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Conventional fertility preservation methods such as oocyte or embryo cryopreservation are currently insufficient to treat including those patients with prepubertal cancer and premature ovarian failure. Ovarian tissue cryopreservation presents as an alternative but has limitations with a potential risk of reintroducing malignant cells in patients who recover from cancer, those of chemotherapy prior to tissue cryopreservation. The so called “artificial ovary” aims to resolve this issue by transplanting isolated follicles with or without a biological scaffold. The artificial ovary may also offer an effective alternative option for those who cannot benefit from traditional assisted reproductive techniques such as in vitro fertilisation. To date, in animal studies and human trial, the artificial ovary restored endocrine function, achieved in vivo follicular development, and resulted in successful pregnancies. However, development of a technique for higher follicular recovery rate and a more optimised design of delivery scaffold, better transplantation techniques to prevent postsurgical ischemia, and consideration for genetic safety are required for safer and consistent human clinical applications. Ideas from different transplantation surgeries (e.g., entire ovary, ovarian cortex, and transplantation with tissue‐engineered products) can be applied to enhance the efficacy of artificial ovarian transplantation. For the better application of artificial ovary, a deeper understanding of mechanical and biochemical properties of the ovary and folliculogenesis after cryopreservation, transplantation with or without scaffold, and development of sophisticated in vivo imaging techniques of transplanted artificial ovary need to precede its efficient clinical application.

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“…Em humanos, até a presente data, há 30 casos relatados de autotransplante ortotópico de tecido ovariano criopreservado em todo o mundo, alguns com menção a nascidos vivos (1,9,10,46,(69)(70)(71)(72)(73)(74) . São considerados implantes ortotópicos aqueles colocados em janela especialmente criada no peritônio, próxima ao infundíbulo pélvico, classicamente fixados em tela de Surgicell® como descrito por Donnez em 2006 (10) e também os fragmentos suturados diretamente no ovário remanescente (46) .…”

Section: Na Base De Dadosunclassified

Transplante experimental, subcutâneo e intraperitoneal, de ovário em suínos: estudo histomorfométrico e imunoistoquímico

Damásio¹

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A minha filha Maria Luiza, sentido e alegria de minha vida todos os dias.A minha mãe, Maria dos Remédios, pelo amor, apoio e força sempre, maravilhosa e incontestavelmente presentes em todos os momentos de minha vida.A meu pai, Edson, pelo exemplo irretocável, compreensão, incentivo diário, amor e carinho infinitos.A meus irmãos, Esaú e Noeme, pela amizade crescente, amor indiscutível e parceria indissolúvel.A minhas irmãzinhas, Letícia, Larissa e Naiara, e a meu sobrinho Erick, pela vontade que me trazem de ser uma pessoa melhor.A meu marido, Helder, pelo amor, paciência, cooperação e incentivo tão importantes para eu ser verdadeiramente quem sou e para minha plena felicidade.A meu padrasto, José Paulo, pelo amor, respeito e educação concedidos, cultivados e aprimorados nesses anos de convivência.A meu cunhado, Rufino Filho, irmão desta e de outras vidas, pela presença e apoio constantes em minha vida, dos simples detalhes às grandes decisões.A meu sogro, Rufino Damásio, pelo apoio e incentivo indispensáveis para a conclusão desta tese e pelas contribuições constantes em minha formação humana e afetiva. AGRADECIMENTOSAo Professor Doutor Edmund Chada Baracat, por ser admirável exemplo de ser humano, professor e profissional, daqueles que contribuem para o crescimento e melhoria de todos a sua volta, com competência e compreensão.Ao Professor Doutor José Maria Soares Júnior, pelas incontestáveis dedicação e sapiência e pelo apoio e ensinamentos nesta caminhada.Ao Professor Doutor Manuel de Jesus Simões, pelas contribuições preciosas, pelo conforto emocional e apoio científico sem horas marcadas.Ao companheiro Jairo Iavelberg, pelo apoio em todas as horas, pela facilidade de comunicação que viabilizou esta pesquisa e pela participação nos procedimentos e nas buscas árduas da pós-graduação.Ao Professor Doutor Eduardo Vieira da Motta, pela sabedoria e bom senso que fazem parte de seu cotidiano e pelas contribuições constantes e precisas a minha formação pessoal e profissional.Às melhores amigas que uma Residência pôde proporcionar a alguém nessa vida: Lisandra Stein Bernardes, Maria Teresa Roncaglia e Camila Locci Bontempo, tão diferentes entre si e tão maravilhosamente influentes e importantes em minha vida, com o apoio, carinho e companheirismo infalíveis na alegria e na tristeza.A meu amigo Felipe Fittipaldi, sempre corajoso, confiável, carinhoso e companheiro.A meus amigos Leonardo Sérvio Luz, Danielle Dourado Magalhães e Thaís Araújo Fortes, espelhos em que posso ver, verdadeiramente, minha alma refletida e amores eternos, sempre presentes e confiantes no êxito desta jornada.Aos queridos Cristiane, Célia, Mara, Leslie, Moacyr e Sônia, anjos do cotidiano, das alegrias e das dificuldades de todos meus passos na Clínica Ginecológica da FMUSP.À Sra. Claudia Vieira, profunda conhecedora da Pós-Graduação da FMUSP e colaboradora atenciosa e eficiente para efetivação desta tese.Ao Instituto Israelita de Ensino e Pesquisa-IIEP do Hospital Israelita Albert Einstein-HIAE, pela magnífica estrutura física concedida e pelo a...

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The First Orthotopic Ovarian Transplant in Turners Syndrome

Cited by 5 publications

References 0 publications

Restoration of Endocrine Function and Fertility with Orthotopic Tubal—Ovarian Allotransplant as the Anatomical-Functional Unit in Rabbits

Restoration of Endocrine Function and Fertility with Orthotopic Tubal—Ovarian Allotransplant as the Anatomical-Functional Unit in Rabbits

A new possibility in fertility preservation: The artificial ovary

Transplante experimental, subcutâneo e intraperitoneal, de ovário em suínos: estudo histomorfométrico e imunoistoquímico

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