The First Polish Liver Transplantation after Roux-en-Y Gastric Bypass Surgery for Morbid Obesity: A Case Report and Literature Review

Marszałek, Rafał; Ziemiański, Paweł; Łągiewska, B; Pacholczyk, Marek; Domienik‐Karłowicz, Justyna; Trzebicki, Janusz; Wierzbicki, Zbigniew; Jankowski, Krzysztof; Kosieradzki, Maciej; Wasiak, Dariusz; Jonas, Maurycy; Pruszczyk, Piotr; Durlik, M.; Lisik, Wojciech; Chmura, A.

doi:10.12659/aot.893797

Cited by 7 publications

(4 citation statements)

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“…It was estimated that in 2008 in the United States alone, the cost of the medical consequences of obesity are around $150 billion [ 1 ]. It is a risk factor for many chronic diseases, including diabetes, cardiovascular disease, strokes, some types of cancer, and hepatic cirrhosis requiring transplantation [ 2 – 4 ].…”

Section: Epidemiology Of Overweight and Obesitymentioning

confidence: 99%

Obesity and Pelvic Floor Disorders: A Review of the Literature

et al. 2016

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Overweight and obesity are becoming a worldwide health problem associated with numerous co-morbidities. National costs of obesity and pelvic flor disorders have been rising since the 1950s across the world. Obesity is thought to have a very strong effect on pelvic floor disorders, and, considering the high prevalence of both problems worldwide, it is of utmost importance to evaluate the association between these pathologies as well as the impact of obesity on treatment efficacy. This review is based on a selection of reports in the literature (PubMed search), including guidelines and Cochrane reviews.Obesity seems to be a well-documented risk factor for lower urinary tract symptoms (LUTS) and is a predictor of exacerbation of stress urinary incontinence (SUI) and overactive bladder (OAB). Weight loss is also associated with improvement or resolution of SUI and OAB. In the case of pelvic organ prolapse (POP), weight loss is associated with improvement in quality of life. Although obesity is associated with POP in general, the exact role of obesity in symptomatic POP remains uncertain. While outcomes of anti-incontinence surgery among obese women are similar to those in non-obese women, postoperative urge incontinence is more likely to occur. It seems that obesity is not a risk factor for postoperative complications or short-term efficacy of POP surgical treatment. Long-term effects are still uncertain.Obesity is a strong risk factor for LUTS, but in most cases it does not affect efficacy of operative treatment. It may be associated with some post-operative complications. Weight loss in many cases allows avoiding surgical intervention.

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Section: Epidemiology Of Overweight and Obesitymentioning

confidence: 99%

Obesity and Pelvic Floor Disorders: A Review of the Literature

et al. 2016

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“…At present, there are 4 articles that have reported on the outcomes of patients with a history of BS before LT in a combined 38 patients. [14][15][16][17] Table 4 summarizes the critical findings of each study, including those presented herein.…”

Section: Discussionmentioning

confidence: 99%

“…At present, only 4 publications have reported on the outcomes of patients with a history of BS before LT in a combined 38 patients. [14][15][16][17] The variance and differing perspective of each study demonstrates the heterogeneity on this subject and the lack of cogent evidence to draw from.…”

Section: Introductionmentioning

confidence: 99%

Clinical Impact of Antecedent Bariatric Surgery on Liver Transplant Outcomes: A Retrospective Matched Case-control Study

et al. 2020

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Original Clinical Science-Liver Background. Bariatric surgery (BS) may be associated with significant malabsorption and nutritional deficiencies. Methods. Between March 1987 and January 2017, we performed 922 liver transplants (LT) at our institution; 33 had antecedent BS. We matched the BS cohort to LT recipients without BS (1:3 matching) based on exact matching for gender and cancer and inverse variance matching for age, LT body mass index, MELD score, and transplant date. Results. We analyzed outcomes in 132 LT recipients (33 BS; 99 non-BS). The BS cohort comprised 26 (79%) women with a mean age of 52.4 years. The BS procedures included 20 Roux-en-Y gastric bypass (61%), 6 jejunoileal bypass (18%), 3 gastric band (9%), 2 sleeve gastrectomy (6%), and 1 duodenal switch (3%). The primary indications for LT listing were alcoholic cirrhosis (9; 27%), nonalcoholic steatohepatitis (7; 21%), hepatitis C (8; 24%), and hepatocellular carcinoma (3; 9%). At LT, body mass index for the BS cohort was 29.6, and MELD was 24. Compared with matched controls, BS recipients did not have longer LT length of hospital stay (17.8 versus 15.7 d, P = 0.71), longer intensive care unit length of stay (5.3 versus 4.1 d, P = 0.16), or higher 30-day complication rate (76% versus 85%, P = 0.43). Overall patient survival was similar (1-and 3-y survival was 90.1% and 75.9% for BS; 90.9% and 76.4% for non-BS, P = 0.34). Conclusions. A history of BS does not portend a deleterious effect on LT outcomes.

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“…87 Although rare, cases of acute liver dysfunction following RYGB have been described in a small case series (Table 1). 7,9,[88][89][90] In total, 15 patients with different stages of liver dysfunction after RYGB were identified: 2 (13%) patients with mild liver dysfunction, 6 (40%) patients with ALI, and 7 (47%) patients with ALF. Eight of 15 (53%) patients recovered: 2 (13%) with nutritional support, 4 (27%) after revision or conversion of the RYGB, and 2 (13%) by means of LTx.…”

Section: Rygbmentioning

confidence: 99%

Liver Injury and Acute Liver Failure After Bariatric Surgery

Moolenaar

Waard²,

Heger

et al. 2022

Journal of Clinical Gastroenterology

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The obesity epidemic has caused a surge in the use of bariatric surgery. Although surgery-induced weight loss is an effective treatment of nonalcoholic fatty liver disease, it may precipitate severe hepatic complications under certain circumstances. Acute liver injury (ALI) and acute liver failure (ALF) following bariatric surgery have been reported in several case series. Although rare, ALI and ALF tend to emerge several months after bariatric surgery. If so, it can result in prolonged hospitalization, may necessitate liver transplantation, and in some cases prove fatal. However, little is known about the risk factors for developing ALI or ALF after bariatric surgery and the mechanisms of liver damage in this context are poorly defined. This review provides an account of the available data on ALI and ALF caused by bariatric surgery, with emphasis on potential injury mechanisms and the outcomes of liver transplantation for ALF after bariatric surgery.

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The First Polish Liver Transplantation after Roux-en-Y Gastric Bypass Surgery for Morbid Obesity: A Case Report and Literature Review

Abstract: Steatohepatitis in morbidly obese patients may lead to cirrhosis. Bariatric procedure can be a bridge to liver transplantation for morbidly obese patients with advanced liver fibrosis.

Cited by 7 publications

References 0 publications

Obesity and Pelvic Floor Disorders: A Review of the Literature

Obesity and Pelvic Floor Disorders: A Review of the Literature

Clinical Impact of Antecedent Bariatric Surgery on Liver Transplant Outcomes: A Retrospective Matched Case-control Study

Liver Injury and Acute Liver Failure After Bariatric Surgery

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