The First Reported Case of Majocchi’s Granuloma with<i>Malbranchea</i>sp. in an Immunocompetent Patient

Govind, Anusha; L’Etoile, Nathan; Vásquez, Gustavo

doi:10.1155/2017/9196528

Cited by 2 publications

(3 citation statements)

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“…Non-dermatophytic fungi such as those belonging to the genera Phoma and Aspergillus were also reported as etiological agents of MG. 9 , 67 Among the 33 cases that were reviewed, only one study reported the presence of a non-dermatophytic but keratinophilic fungus, a Malbranchea species, in an immunocompetent patient who had eczema as the underlying disease. 68 …”

Section: Laboratory Diagnosismentioning

confidence: 99%

“…Although ketoconazole was frequently used previously, about half of the patients reported today are treated with terbinafine (250 mg/day). 8 , 13 , 36 , 40 , 43 , 47 , 54 , 68 – 71 Other systemic antifungal drugs are itraconazole (100–200 mg/day), 32 , 44 , 53 , 72 griseofulvin (250–500 mg/day), 10 , 35 , 63 voriconazole, 73 and posaconazole. 28 Antifungal therapy should be continued until the lesions are completely resolved.…”

Section: Treatmentmentioning

confidence: 99%

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Majocchi’s granuloma: current perspectives

Boral¹,

Durdu²,

İlkit³

2018

IDR

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Majocchi’s granuloma (MG) is a rare fungal infection of the dermis that is mainly caused by dermatophytes (in ≥95% of cases); the most frequently identified cause is anthropophilic Trichophyton rubrum. In the rest of the cases, the causes are non-dermatophytic fungi such as Aspergillus species. This review aimed to provide information about the current perspectives on MG regarding its clinical characteristics, predisposing factors, laboratory diagnosis, and treatment strategies. Although the lower extremities were reported to be the most common site of infection, facial involvement has been predominant in the past 5 years. Our literature research showed that the most common predisposing factor (55%) is the use of topical steroid creams without potassium hydroxide examination during treatment of erythematous squamous dermatoses. A reliable diagnosis of MG is based on histopathological examination, including fungal culture and molecular analyses. MG should be treated not only with topical agents but also with systemic antifungal agents that are continued until the lesions are completely resolved. In systemic treatment, the most preferred drug is terbinafine, because of its efficacy, side effects, and safety.

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Section: Laboratory Diagnosismentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

Majocchi’s granuloma: current perspectives

Boral¹,

Durdu²,

İlkit³

2018

IDR

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“…More recently, Malbranchea spp. have been proposed as one of the causative agents of Majocchi's granuloma (Govind et al 2017;Durdu et al 2019). In a study of 245 patients with fungal saprophytic infections of nails and skin, Malbranchea spp.…”

Section: Introductionmentioning

confidence: 99%

A revision of malbranchea-like fungi from clinical specimens in the United States of America reveals unexpected novelty

et al. 2021

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The fungi of the order Onygenales can cause important human infections; however, their taxonomy and worldwide occurrence is still little known. We have studied and identified a representative number of clinical fungi belonging to that order from a reference laboratory in the USA. A total of 22 strains isolated from respiratory tract (40%) and human skin and nails (27.2%) showed a malbranchea-like morphology. Six genera were phenotypically and molecularly identified, i.e. Auxarthron/Malbranchea (68.2%), Arachnomyces (9.1%), Spiromastigoides (9.1%), and Currahmyces (4.5%), and two newly proposed genera (4.5% each). Based on the results of the phylogenetic study, we synonymized Auxarthron with Malbranchea, and erected two new genera: Pseudoarthropsis and Pseudomalbranchea. New species proposed are: Arachnomyces bostrychodes, A. graciliformis, Currahmyces sparsispora, Malbranchea gymnoascoides, M. multiseptata, M. stricta, Pseudoarthropsis crassispora, Pseudomalbranchea gemmata, and Spiromastigoides geomycoides, along with a new combination for Malbranchea gypsea. The echinocandins showed the highest in vitro antifungal activity against the studied isolates, followed by terbinafine and posaconazole; in contrast, amphotericin B, fluconazole, itraconazole and 5-fluorocytosine were less active or lacked in vitro activity against these fungi.

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The First Reported Case of Majocchi’s Granuloma withMalbrancheasp. in an Immunocompetent Patient

Cited by 2 publications

References 7 publications

Majocchi’s granuloma: current perspectives

Majocchi’s granuloma: current perspectives

A revision of malbranchea-like fungi from clinical specimens in the United States of America reveals unexpected novelty

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The First Reported Case of Majocchi’s Granuloma withMalbrancheasp. in an Immunocompetent Patient

Cited by 2 publications

References 7 publications

Majocchi&rsquo;s granuloma: current perspectives

Majocchi&rsquo;s granuloma: current perspectives

A revision of malbranchea-like fungi from clinical specimens in the United States of America reveals unexpected novelty

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Majocchi’s granuloma: current perspectives

Majocchi’s granuloma: current perspectives