The first Russian multicenter non-interventional registry study to study the incidence of vitamin D deficiency and insufficiency in Russian Federation

Суплотова, Л. А.; Pigarova, Ekaterina; Rozhinskaya, Liudmila; Karonova, Tatiana; Troshina, Ekaterina A.

doi:10.26442/00403660.2021.10.201071

Cited by 17 publications

(3 citation statements)

References 23 publications

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“…Existing data on vitamin D status among the Russian population is available for small populations of limited generalizability, due to a recent monograph edited by Kodentsova 17 , epidemiological studies which run in frame of dietary intake monitoring from 2012 to 2017 represented by several groups: children and adolescents (7–14 years; n = 790), students (Arkhangelsk; n = 58), pregnant female (Moscow; n = 100), etc. Despite these limitations, findings are generally consistent in that 50–91% of the working-age population has reduced vitamin D concentrations (< 30 ng/mL) regardless of age, sex and season of data collection 18 . Systematic assessments of the indigenous population of the Russia north also exhibit high levels of sub-optimal vitamin D concentrations 19 .…”

Section: Introductionmentioning

confidence: 78%

Vitamin D status of the Russian adult population from 2013 to 2018

Smirnova¹,

Rehm

Fritz

et al. 2022

Sci Rep

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Vitamin D deficiency is widespread globally, however available data for the Russian adult population is fragmented. This cross-sectional study used secondary data for individuals undergoing testing for vitamin D concentrations from 2013 to 2018 by InVitro laboratory. 25(OH)D serum concentration was determined using chemiluminescent microparticle immunoassay. The mean, median, and proportion with severe, deficient, insufficient and sufficient 25-hydroxyvitamin D (25(OH)D) concentrations were estimated. Splines examined the effect of latitude on 25(OH)D concentrations. Data were available for 30,040 subjects age ≥ 18 years. 24.2% of the sampled population had sufficient (30–< 150 25(OH)D ng/mL), 34% deficient (10–19.9 ng/mL) and 5.6% severely deficient (< 10 ng/mL) status. Average 25(OH)D concentrations were highest among 30–44 years and lowest amongst older adults; females had modestly higher values. Concentrations were 15% higher in fall/summer vs. winter/spring. A non-linear relationship was observed by latitude; the highest 25(OH)D concentrations were observed near 54°N, decreasing at more southern latitudes for women and more northern latitudes for both sexes. These results are comparable to other Northern European publications and limited Russian samples demonstrating low concentrations. Acknowledging that nationally-representative and randomly sampled data are needed, the present data suggest the burden may be high and identifies some population sub-groups and geographic areas with a higher potential deficiency of vitamin D.

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Section: Introductionmentioning

confidence: 78%

Vitamin D status of the Russian adult population from 2013 to 2018

Smirnova¹,

Rehm

Fritz

et al. 2022

Sci Rep

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“…The general trends indicated lower concentrations of vitamin D in men, regardless of season and age. In women, the lowest vitamin D content is observed in old age, regardless of the season of the year [53][54][55].…”

Section: Discussionmentioning

confidence: 97%

The functional states of the participants of a marine Arctic expedition with different levels of vitamin D in blood

Simonova¹,

Kirichek²,

Trofimova³

et al. 2023

Preprint

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(1) Background: The issue of human adaptation to the Arctic environmental factors is relevant. The adaptation can be assessed through dynamic monitoring of the functional state of a person during his/her stay there. The vitamin D level in blood is one of the markers of the functional reserves of the human body and can contribute to more successful adaptation in the Arctic. (2) Methods: The study involved 38 participants in the scientific and educational expeditionary project "Arctic Floating University-2021". Blood collection for determination of vitamin D content was carried out at the beginning of the expedition. A dynamic study was carried out for 20 days in the morning and in the evening during a marine scientific expedition to the Arctic. The main parameters of the functional state of the participants were assessed using instrumental psychophysiological, projective and questionnaire methods. Statistical methods: Mann-Whitney U-test, correlation analysis using the Spearman coefficient. (3) Results: It was found that at the beginning of the expedition, the functional state of participants with severe vitamin D deficiency is characterized by a shorter average duration of RR intervals and reduced SDNN values, which may indicate a higher level of regulatory mechanisms tension. The pronounced differences in the nature of the dynamic series of objective and projective working capacity parameters were manifested most clearly. According to the subjective questionnaire characteristics of well-being, activity and mood, no significant features of the participants with vitamin D deficiency were revealed. (4) Conclusion: The participants with vitamin D deficiency in blood are characterized by a reduced adaptive capacity during the expedition to the Arctic.

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“…First of all, our study further supported the prevalence of very low vitamin D levels in patients with COVID-19. The median level of 25OH-D 3 in COVID-19 patients was only 10.8 ng/mL, which corresponds to a pronounced vitamin D deficiency in a major part of the examined patients [ 41 ] and depicts worse vitamin D status than epidemiological data from a similar season [ 44 ]. Similar results have been demonstrated in a number of previous studies from various countries [ 45 ], and the amount of evidence continues to increase [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Impaired Vitamin D Metabolism in Hospitalized COVID-19 Patients

et al. 2022

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There is increasing data regarding the association between vitamin D and COVID-19. This study aimed to reveal the alterations of vitamin D metabolism in the setting of COVID-19. We examined 119 adult COVID-19 inpatients and 44 apparently healthy adult individuals with similar serum 25OH-D3 levels as a reference group. The assessment included serum biochemical parameters (total calcium, albumin, phosphorus, creatinine), parathyroid hormone (PTH), vitamin D-binding protein (DBP), vitamin D metabolites (25OH-D3, 25OH-D2, 1,25(OH)2D3, 3-epi-25OH-D3, 24,25(OH)2D3 and D3) and free 25OH-D. COVID-19 patients had in general very low vitamin D levels (median 25OH-D3 equals 10.8 ng/mL), accompanied by an increased production of the active vitamin D metabolite (1,25(OH)2D3), estimated as higher 1,25(OH)2D3 serum levels (61 [44; 81] vs. 40 [35; 50] pg/mL, p < 0.001) and lower 25OH-D3/1,25(OH)2D3 ratio (175 [112; 260] vs. 272 [200; 433], p < 0.001) which is presumably aimed at preventing hypocalcemia. Patients with COVID-19 also had elevated DBP (450 [386; 515] vs. 392 [311; 433] mg/L, p < 0.001) and low free 25OH-D levels (<LoB vs. 3.9 [3.2; 4.4] pg/mL, p < 0.001). Follow-up assessment of the COVID-19 inpatients showed recovery of the observed changes. Overall, hospitalized patients with an acute course of COVID-19 have not only very low levels of 25OH-D but also profound abnormalities in the metabolism of vitamin D regardless of the clinical course of the disease. These alterations might exacerbate existing vitamin D deficiency and its negative impact.

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The first Russian multicenter non-interventional registry study to study the incidence of vitamin D deficiency and insufficiency in Russian Federation

Cited by 17 publications

References 23 publications

Vitamin D status of the Russian adult population from 2013 to 2018

Vitamin D status of the Russian adult population from 2013 to 2018

The functional states of the participants of a marine Arctic expedition with different levels of vitamin D in blood

Impaired Vitamin D Metabolism in Hospitalized COVID-19 Patients

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