The first urinary tract infection caused by Cedecea lapagei: a case report and review of the literature

Çekın, Yeşim; Kızılateş, Filiz; Dolu, Süleyman; Öztoprak, Nefise; Çekın, Ayhan Hilmi

doi:10.5455/gmj-30-153282

Cited by 8 publications

(9 citation statements)

References 13 publications

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“…Cedecea spp. rarely cause urinary tract infections and the only reported case so far was due to Cedecea lapagei (Cekin et al, 2014). The current report is the first time Cedecea davisae is incriminated as aetiologic agent of UTI.…”

Section: Discussionmentioning

confidence: 71%

“…as human pathogens. Members of the genus have been isolated from human clinical specimens including urine (Cekin et al, 2014), blood (Dalamago et al, 2008a;Dalamago et al, 2008b;Abate et al, 2011;Akinosoglou et al, 2012;Peretz et al, 2013;), Ulcer (Dalamago et al, 2008b, Mawardi et al, 2010Biswal and Hussan, 2015), sputum (Yetkin et al, 2008;Bozkurt, 2014).…”

Section: Introductionmentioning

confidence: 99%

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A primal incrimination of<i> Cedecea davisae</i> with post-prostatectomy urinary tract infection in Nigeria

Agbonlahor¹,

Ehiaghe²,

Eremwanarue³

et al. 2018

Int. J. Bio. Chem. Sci

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Cedecea species are recent members of the family Enterobacteriaceae and are rarely incriminated in human infections. A patient with protracted urinary tract infection, post-prostatectomy, was referred to Lahor Research Laboratories, Benin City, Nigeria for routine culture and susceptibility testing. Three consecutive mid-stream urine samples from him yielded pure, heavy, growths of an apparently same Gram negative, nonspore forming, non-capsulated, motile, rod-shaped bacterium, which was lipase, citrate, methyl red, KCN, ONPG, arginine and ornithine decarboxylase positive. It was oxidase, urease, H 2 S, indole, gelatinase, deoxyribonuclease and phenylalanine deaminase negative. It fermented glucose, xylose, sucrose, salicin, maltose mannitol, and lactose but was negative arabinose, inositol, dulcitol, raffinose, rhamnose and melibiose. It exhibited multiple antibiotic resistances to augmentin, gentamicin, ofloxacin, cefixime, ciprofloxacin, ceftazidime and cefuroxime but was very sensitive to imipenem and moderately susceptible to nitrofurantoin. The isolate was identified phylogenetically as Cedecea davisae. It possessed plasmid at 48.5 kb and harboured SHV, TEM, and gyrA antibiotic-resistance genes, which were either plasmid-mediated, chromosomal-mediated or both. To the best of knowledge, this is the first report on the incrimination of this organism with human infection in Nigeria. It was concluded that the paucity of reports on Cedecea species as aetiologic agents of human infections could be as a result of the difficulty in recognizing and characterizing this recently described pathogen, particularly in low resource laboratories, coupled with the fact that Laboratorians and Physicians are yet to be fully aware of the emerging clinical significance of this "relatively new" organism.

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Section: Discussionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%

A primal incrimination of<i> Cedecea davisae</i> with post-prostatectomy urinary tract infection in Nigeria

Agbonlahor¹,

Ehiaghe²,

Eremwanarue³

et al. 2018

Int. J. Bio. Chem. Sci

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“…This case report described an extremely rare case of clinically signi cant urinary tract infections caused by Cedecea lapagei. The treatment of Cedecea species infections represents a challenging issue due to its multi-drug resistant and extensive drug resistance patterns to a variety of antimicrobial antibiotics, such as extended-spectrum beta-lactamases, cephalosporins, and beta-lactam inhibitors as the present case have been noticed (6). The patient responded well with levo oxacin after drug adjustment due to the preexisting azotemia.…”

Section: Discussionmentioning

confidence: 61%

Cedecea lapagei An Extremely Rare Uropathogen: A Case Report and Review of the Literature

Mohamed¹,

Mohamud²

2021

Preprint

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Background: Gram-negative enterobacteria are the most common cause of urinary tract infections. Cedecea is a new separate genus in the family enterobacteriaceae, and it is a very rare pathogen that was primarily found in the respiratory tract. Cedecea lapagei is a very rare pathogen of urinary tract infections. To the best of our knowledge, this is the first case report in the world reported in English literature. Case presentation: A 55 years old man with chronic renal failure, poorly controlled diabetes mellitus, and hypertension presented with acute exacerbations of renal failure and irritative voiding symptoms. After stabilization and empirical antibiotic therapy with Ceftriaxone, the patient’s condition was not improved and deteriorated progressively. After the request of urine culture, the culture was isolated, an extremely rare uropathogen recently recognized by the Centers for Disease Control and Prevention (CDC); the Cedecea lapagei. Cedecea lapagei identification had been done using Eosin methylene blue agar (EMB). Gram-negative lipase positive bacteria with bacillus in shape, motile in nature that is non-spore-forming, and non-encapsulated enterobacteria with the final result of >100,000 colony-forming units per ml of Cedecea lapagei were isolated. Mueller-Hinton agar had been used to perform antimicrobial sensitivity and resistance. The pathogen was extensively resistant to the extended-spectrum beta-lactamases antibiotics and extended-spectrum beta-lactam inhibitors while carbapenems, fluoroquinolones, aminoglycosides, and Trimethoprim-sulfamethoxazole showed a higher sensitivity rate. Conclusion: The treatment of Cedecea lapagei infections represents a challenging issue due to its multi-drug resistant and extensive drug resistance patterns to a variety of antimicrobial classes, such as extended-spectrum beta-lactamases, cephalosporins, and beta-lactam inhibitors. Antimicrobial treatment should be aligned with the culture findings once available.

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“…The majority of case reports related to ours have narrated good outcomes and favorable responses to antibiotics [ 1 , 6 – 9 , 13 , 14 ]. Antibiograms were performed in such cases, revealing an invariable resistance pattern.…”

Section: Discussionmentioning

confidence: 98%

Death related to Cedecea lapagei in a soft tissue bullae infection: a case report

et al. 2018

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BackgroundCedecea lapagei bacterium was discovered in 1977 but was not known to be pathogenic to humans until 2006. In the medical literature there are very few clinical case reports of Cedecea lapagei; none have reported a catastrophic death secondary to a soft tissue hemorrhagic bullae infection. As well as soft tissue infection, rare cases of pneumonia, urinary tract infections, peritonitis, osteomyelitis, bacteremia, and sepsis have been documented with the majority having good outcomes. Here, we present the first case of a fatal outcome in a Cedecea lapagei soft tissue infection with multiple hemorrhagic bullae.Case presentationA 52-year-old Mexican man with antecedents of liver cirrhosis and treated hypertension was brought to our institution with clinical signs of sepsis and 16 to 18 hours of history of pain and edema in his right lower limb. During the course of the first day hospitalized in our institution, he developed several large serohematogenous bullae with ascending progression on his entire right lower limb. He subsequently developed multiple organ failure and septic shock with rapid deterioration, dying on the second day. Bullae fluid samples taken the first day undoubtedly isolated Cedecea lapagei within the second day using MicroScan WalkAway® 96 plus System as well Gram-negative bacteria in MacConkey and blood agar.ConclusionsThe isolation of Cedecea lapagei was an unexpected etiological finding that will enable physicians in the future to consider this bacterium as a probable cause of serohematogenous bullae infections. We do not exclude contamination although it has never been isolated in bullae fluid in the medical literature. Future encounters with this bacterium should not be taken lightly as it may have the potential to have fatal outcomes.

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The first urinary tract infection caused by Cedecea lapagei: a case report and review of the literature

Cited by 8 publications

References 13 publications

A primal incrimination of<i> Cedecea davisae</i> with post-prostatectomy urinary tract infection in Nigeria

A primal incrimination of<i> Cedecea davisae</i> with post-prostatectomy urinary tract infection in Nigeria

Cedecea lapagei An Extremely Rare Uropathogen: A Case Report and Review of the Literature

Death related to Cedecea lapagei in a soft tissue bullae infection: a case report

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