Objective As of 11 April 2020, there were 68,192 confirmed cases, including 4,232 deaths. This study aimed to estimate the net present value of human lives lost due to COVID-19 in Iran as of 11 April 2020.Results The 4,232 human lives lost had a total net present value of Int$ 436,275,007. The average net present value per human life was Int$103,090. Re-estimation of the economic model with 5% and 10% discount rates resulted in a reduction in the expected total net present value by Int$ 64,881,144 (14.9%) and Int$ 168,066,782 (38.5%), respectively. Additional re-calculation of the economic model using the highest life expectancy in the world (i.e., that of the Japanese Females) increased the total net present value of human lives lost by 114%.