We examine the determinants of employees' intention to apply ergonomics at workplace and the moderating effects of Hofstede's cultural dimensions on the proposed research model. A research model, based on the decomposed theory of planned behaviour (DTPB), the unified theory of acceptance and use of technology model (UTAUT), and Hofstede's cultural dimensions, is developed. A sample of 150 employees from the state of Qatar was used to test the proposed research model. The antecedent variables considered are attitude, social influence, perceived behavioural control, self-efficacy, facilitation conditions, performance expectancy, effort expectancy, compatibility and management support. The results show that attitude, perceived behavioural control, and social influence have significant positive effects on employees' behavioural intention to apply ergonomics at the workplace. Compatibility and performance expectancy have significant positive indirect effects on behavioural intention through attitude. Additionally, facilitation conditions and self-efficacy have significant positive indirect effects on behavioural intention through perceived behavioural control. Hofstede's cultural dimensions significantly moderate the hypothesised relationships.