The flavivirus dengue induces hypertrophy of white matter astrocytes

Lee, Kim M.; Chiu, Kevin B.; Sansing, Hope A.; Didier, Peter J.; Lackner, Andrew A.; MacLean, Andrew G.

doi:10.1007/s13365-016-0461-4

Cited by 12 publications

(11 citation statements)

References 22 publications

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“…Astrocyte hypertrophy has been detected in a mouse model of ZIKV infection (Bell et al, 1971) and is occurring for other Flavivirus CNS infection such as WNV (Hussmann et al, 2013), DENV (Lee et al, 2016) and the Alphavirus CHIKV (Inglis et al, 2016). Interestingly, AXL, a molecule suggested as a putative attachment receptor for ZIKV (Hamel et al, 2015) is highly expressed in NSCs but also in astrocytes (Nowakowski et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Zika Virus Strains Potentially Display Different Infectious Profiles in Human Neural Cells

et al. 2016

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The recent Zika virus (ZIKV) epidemic has highlighted the poor knowledge on its physiopathology. Recent studies showed that ZIKV of the Asian lineage, responsible for this international outbreak, causes neuropathology in vitro and in vivo. However, two African lineages exist and the virus is currently found circulating in Africa. The original African strain was also suggested to be neurovirulent but its laboratory usage has been criticized due to its multiple passages. In this study, we compared the French Polynesian (Asian) ZIKV strain to an African strain isolated in Central African Republic and show a difference in infectivity and cellular response between both strains in human neural stem cells and astrocytes. Consistently, this African strain led to a higher infection rate and viral production, as well as stronger cell death and anti-viral response. Our results highlight the need to better characterize the physiopathology and predict neurological impairment associated with African ZIKV.

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Section: Discussionmentioning

confidence: 99%

Zika Virus Strains Potentially Display Different Infectious Profiles in Human Neural Cells

et al. 2016

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“…In vitro and in vivo studies point to an involvement of glial cells and innate immune response in DENV infection 15,16 , in one study with rhesus macaques there were no apparent brain histological alteration but a series of virus induced astrocytes alterations, decreasing its number, inducing its activation 15 . There is also evidence of the virus in the cerebrospinal fluid (CSF) of patients 17 .…”

Section: Bhushan Et Al (2018) Found 486% Of Immune-mediated Neurolomentioning

confidence: 99%

<strong>Dengue Fever and Neurology: Well Beyond Hemorrhage and Strokes</strong>

Schlindwein¹,

Bandeira²,

Breis³

et al. 2020

Preprint

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Dengue virus an arbovirus is endemic in an area that comprise almost half of the world's population, contrary to past beliefs that dengue virus differentiate from other neuroinvasive arbovirus due to its lack of neurological invasion and disease related neurological complications excluding hemorrhagic and thromboembolic , the body of evidence have grown to demonstrate a series of neurological manifestations linked to dengue virus with possible mechanisms involving direct virus invasion of the nervous system or immune mediated complications. In this review we provide a wide approach to this neglect but not so rare manifestations of a very common disease.

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“…However, in every case, regardless of whether the astrocytes were infected or not, researchers reported the early and robust response to infection as astrogliosis, which was maintained even after nervous tissue viral clearance. Therefore, astrogliosis could be involved in long-term complications presented in some patients (Lee et al, 2016).…”

Section: Astrocytesmentioning

confidence: 99%

Dengue Virus Infection of Blood–Brain Barrier Cells: Consequences of Severe Disease

et al. 2019

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More than 500 million people worldwide are infected each year by any of the four-dengue virus (DENV) serotypes. The clinical spectrum caused during these infections is wide and some patients may develop neurological alterations during or after the infection, which could be explained by the cryptic neurotropic and neurovirulent features of flaviviruses like DENV. Using in vivo and in vitro models, researchers have demonstrated that DENV can affect the cells from the blood–brain barrier (BBB) in several ways, which could result in brain tissue damage, neuronal loss, glial activation, tissue inflammation and hemorrhages. The latter suggests that BBB may be compromised during infection; however, it is not clear whether the damage is due to the infection per se or to the local and/or systemic inflammatory response established or activated by the BBB cells. Similarly, the kinetics and cascade of events that trigger tissue damage, and the cells that initiate it, are unknown. This review presents evidence of the BBB cell infection with DENV and the response established toward it by these cells; it also describes the consequences of this response on the nervous tissue, compares these evidence with the one reported with neurotropic viruses of the Flaviviridae family, and shows the complexity and unpredictability of dengue and the neurological alterations induced by it. Clinical evidence and in vitro and in vivo models suggest that this virus uses the bloodstream to enter nerve tissue where it infects the different cells of the neurovascular unit. Each of the cell populations respond individually and collectively and control infection and inflammation, in other cases this response exacerbates the damage leaving irreversible sequelae or causing death. This information will allow us to understand more about the complex disease known as dengue, and its impact on a specialized and delicate tissue like is the nervous tissue.

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The flavivirus dengue induces hypertrophy of white matter astrocytes

Cited by 12 publications

References 22 publications

Zika Virus Strains Potentially Display Different Infectious Profiles in Human Neural Cells

Zika Virus Strains Potentially Display Different Infectious Profiles in Human Neural Cells

<strong>Dengue Fever and Neurology: Well Beyond Hemorrhage and Strokes</strong>

Dengue Virus Infection of Blood–Brain Barrier Cells: Consequences of Severe Disease

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