The Flavonoids Ameliorates: Protective Mechanisms in Neurodegenerative Diseases

Gupta, Jaya; Gupta, Amit K.; Gupta, Anil Kumar

doi:10.22192/ijcrcps.2017.04.01.001

Cited by 10 publications

(7 citation statements)

References 50 publications

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“…Body weight change is regarded as an indicator of toxicity in chronic toxic agent exposure. [ 37 ] Several studies demonstrated the relation between lung injury and an increase in the pulmonary index. [ 8,38 ] In the current study, PQ effectively decreased body weight gain and increased pulmonary index in rats, which is in line with findings reported by Pourgholamhossein et al [ 39 ] Furthermore, the administration of CGA can effectively prevent weight changes caused by PQ toxicity.…”

Section: Discussionmentioning

confidence: 99%

Chlorogenic acid protective effects on paraquat‐induced pulmonary oxidative damage and fibrosis in rats

Larki‐Harchegani

Fayazbakhsh

Nourian

et al. 2023

J Biochem & Molecular Tox

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Paraquat (PQ) is a widely used herbicide that can cause severe oxidative and fibrotic injuries in lung tissue. Due to the antioxidant and anti-inflammatory properties of chlorogenic acid (CGA), the present study investigated its effects on PQ-induced pulmonary toxicity. To this end, 30 male rats were randomly categorized into five groups of six. Initially, the first and third groups were treated intraperitoneally (IP) with normal saline and CGA (80 mg/kg) for 28 consecutive days, respectively.The second, fourth, and fifth groups were treated with normal saline and 20 and 80 mg/kg of CGA for 28 consecutive days, respectively, and received a single dose of PQ (IP, 20 mg/kg) on Day 7. Then, the animals were anesthetized with ketamine and xylazine, and lung tissue samples were collected for biochemical and histological examinations. The results showed that PQ significantly increased hydroxyproline (HP) and lipid peroxidation (LPO) and decreased the lung tissue antioxidant capacity.In addition, myeloperoxidase (MPO) activity increased significantly, while glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) activity declined substantially. The administration of therapeutic doses of CGA could prevent the oxidative, fibrotic, and inflammatory effects of PQ-induced lung toxicity, and these changes were consistent with histological observations. In conclusion, CGA may improve the antioxidant defense of lung tissue and prevent the spread of inflammation and the development of PQ-induced fibrotic injuries by enhancing antioxidant enzymes and preventing inflammatory cell infiltration.

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Section: Discussionmentioning

confidence: 99%

Chlorogenic acid protective effects on paraquat‐induced pulmonary oxidative damage and fibrosis in rats

Larki‐Harchegani

Fayazbakhsh

Nourian

et al. 2023

J Biochem & Molecular Tox

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“…The word of lichen planus is derived from the Greek word "leichen" means tree moss and Latin word "planus" means flat 6 . Lichen planus is a chronic T-cell mediated autoimmune disease, which affects the oral mucosa, skin, genital mucosa, scalp, and nails 7 .…”

Section: Discussionmentioning

confidence: 99%

Retiküler liken planus

Muneer¹,

Kashyap²,

Kini³

et al. 2016

Cukurova Medical Journal (Çukurova Üniversitesi Tıp Fakültesi Dergisi)

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AbstractÖz Lichen planus is a chronic systemic disease that commonly involves mucosa of oral cavity . It is more common in females and often reported in middle -aged patients. The disease seems to be mediated by an antigen specific mechanism, activated cytotoxic T cells, non-specific mechanisms like mast cells degradation and matrix metalloproteinase activation. It has different variants based on morphology of lesion and site of involvement. Even though there are various lesions that resemble oral lichen planus clinically and histologically, It can be well recognized with its clinical signs and symptoms. Their symptoms may range from none, through mild discomfort to severe burning sensation. Treatment administered is mainly to resolve this symptoms and discomfort. Since it is considered a potentially malignant disorder, early diagnosis and timely management and regular follow up is very important. The objective of this paper is to report a case of reticular lichen planus and highlight on its proper management.Liken planus, yaygın olarak agız içi boğluğu mukozunun kapsandığı kronik sistemik bir hastalıktır. Bayanlarda daha yaygındır ve sıklıkla orta yaşlı hastalarda rapor edilmiştir. Bu hastalığın, sitotoksik T hücrelerinin aktive ettiği, antijene spesifik bir mekanizma ve hücre degradasyonu ve matriks metalloproteinaz aktivasyonu gibi spesifik olmayan mekanizmalar tarafından aracılık edildiği görülür. Görüldüğü bölge ve lezyonların morfolojine dayalı olarak farklı varyantları vardır. Oral liken planusa klinik ve histolojik olarak benzeyen farklı lezyonlar olsa da klinik belirtileri ve semptomlar sayesinde iyi tanımlanabilir. Semptomları, yoktan, ılımlı rahatsızlığa, şiddetli yanma hissine kadar sıralanabilir. Tedavi uygulaması semptomları ve rahatsızlığı temelde çözer. Potansiyel olarak kötü huylu bir hastalık olduğu düşünüldüğü için, erken teşhis, zaman yönetimi ve düzenli hasta takibi çok önemlidir. bu makalenin amacı, retiküler liken planus vakasını rapor etmek ve uygun yönetimi vurgulamaktır

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“…One of the major fatty acid in P. tricornutum is the ω-3 fatty acid EPA (C20:5), having a significant commercial importance in pharmaceutical and nutraceutical industries [9,10] . These long chain polyunsaturated fatty acids (LC-PUFAs) have a bioactive role against a variety of disorders, including coronary heart disease, thrombosis, and recently in prospective adjuvant therapy in COVID-19-related cardiovascular problems [11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

Media engineering in marine diatom Phaeodactylum tricornutum employing cost-effective substrates for sustainable production of high value renewables

Rehmanji

Nesamma

Khan

et al. 2022

Preprint

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Phaeodactylum tricornutum is a marine diatom, and well-studied model of unicellular microalga. This diatom contains a wide range of high-value renewables (HVRs) with high commercial relevance owing to their importance in human nutrition and health. In this study, we screened P. tricornutum for biomass, eicosapentaenoic acid (EPA) and fucoxanthin production under photoautotrophic and mixotrophic condition with various substrate combinations. Results highlights that culture supplemented with glycerol and urea lead to enhanced biomass, biochemical and HVR production. Further continuous feeding of urea in glycerol supplemented medium results in an increase in biomass yield (0.77 g L-1) by ~ 2-fold. Additionally, continuous feeding of urea channelizes the carbon flux towards biosynthesis of fatty acids increasing FAME content by ~2-fold as compared to the control conditions. Overall EPA and fucoxanthin production was 27 mg L-1 and 11 mg L-1 (~2 & 4 fold) in urea fed cultures respectively. Present study demonstrates efficient valorization of cost-effective substrates such as glycerol and urea for the production of high-value renewables in P. tricornutum.

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The Flavonoids Ameliorates: Protective Mechanisms in Neurodegenerative Diseases

Cited by 10 publications

References 50 publications

Chlorogenic acid protective effects on paraquat‐induced pulmonary oxidative damage and fibrosis in rats

Chlorogenic acid protective effects on paraquat‐induced pulmonary oxidative damage and fibrosis in rats

Retiküler liken planus

Media engineering in marine diatom Phaeodactylum tricornutum employing cost-effective substrates for sustainable production of high value renewables

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