The flower of Hypericum perforatum L.: A traditional source of bioactives for new food and pharmaceutical applications

Kapoor, Swati; Chandel, Rajat; Kaur, Ramandeep; Kumar, Satish; Kumar, Raj; Janghu, Sandeep; Kaur, Arshdeep; Kumar, Vikas

doi:10.1016/j.bse.2023.104702

Cited by 12 publications

(4 citation statements)

References 120 publications

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“…Hypericum perforatum L. (St. John's wort) is the most popular medicinal plant worldwide due to a broad diversity of phenolic compounds with pharmacological properties [1]. The aerial parts of H. perforatum wild-growing plants represented the main source of naphthodiathrones, acyl-phloroglucinols, flavonol glycosides, flavan-3-ols, and phenolic acids, while roots synthesized significant amounts of xanthones [2,3]. The naphthodianthrone hypericin commonly distributed into dark glands on the leaf and petal margins has been shown as a powerful photosensitizer used in photodynamic therapy of cancer and virus diseases [4].…”

Section: Introductionmentioning

confidence: 99%

“…The naphthodianthrone hypericin commonly distributed into dark glands on the leaf and petal margins has been shown as a powerful photosensitizer used in photodynamic therapy of cancer and virus diseases [4]. In addition, prenylated phloroglucinols and flavonoids possessed antidepressant, anti-inflammatory, antimicrobial, antioxidant, and wound-healing activities [1,2]. The xanthones have been proposed as promising compounds with antibacterial, antifungal, and antidiabetic properties [5,6].…”

Section: Introductionmentioning

confidence: 99%

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Production of Phenylpropanoids, Naphthodianthrones and Antioxidant Status of Hypericum perforatum L. Transgenic Shoots

Tusevski,

Todorovska,

Todorovska

et al. 2024

Horticulturae

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Fifteen transgenic shoot clones (TS A-TS O) regenerated from Hypericum perforatum hairy roots were evaluated for growth characteristics, phenylpropanoid, and naphthodianthrone production, as well as non-enzymatic and enzymatic antioxidant status. Transgenic shoots displayed higher biomass production and non-altered phenotypes compared to control shoots. Phenylpropanoid production in TS was not related to phenylalanine ammonia lyase activity indicating that alternative enzymes could be involved in the regulation of phenylpropanoid/flavonoid biosynthesis. The positive correlation between phenylpropanoids (phenolic acids, flavonoids, flavan-3-ols, tannins) and non-enzymatic antioxidant assays suggested that these compounds are the main contributors to the redox state and radical scavenging properties of TS clones. More importantly, enhanced naphthodianthrone production (hypericin, pseudohypericin and protopseudohypericin) in TS was associated with the number of leaf dark glands. Concerning the enzymatic antioxidant status of TS, guaiacol peroxidase was shown as the main enzyme that turns down H2O2 levels, while the upregulation of superoxide dismutase coincided with decreased O2•− production. The efficiency of antioxidant enzymes for O2•− and H2O2 neutralization decreased the level of MDA and consequently delayed lipid peroxidation in TS clones. Altogether, H. perforatum transgenic shoots could be proposed as a prospective biotechnological system for scale-up production of naphthodianthrones and phenylpropanoids with antioxidant properties.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Production of Phenylpropanoids, Naphthodianthrones and Antioxidant Status of Hypericum perforatum L. Transgenic Shoots

Tusevski,

Todorovska,

Todorovska

et al. 2024

Horticulturae

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“…According to previous studies, 0.5 g of H. perforatum mixed with 100 g of wheat flour enhances the bioactive compounds of wheat cookies [4], and H. perforatum water honey extract is used to extend the shelf life of bread [5]. In addition, it is reported that H. perforatum is a safe and non-cytotoxic ingredient as it is used in pharmaceuticals, cosmetics, and foods [6,7]. Mastic is a natural resin derived from the P. lentiscus var.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Antifungal Activity of Various Natural Extracts in a Sustainable Saccharomyces cerevisiae Model Using Cell Viability, Spot Assay, and Turbidometric Microbial Assays

Letsiou,

Pyrovolou,

Konteles

et al. 2024

Applied Sciences

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Saccharomyces cerevisiae is a sustainable yeast with many applications in the food industry. Here, we study the use of a Saccharomyces cerevisiae model composed of three different industrial strains (a wine, a beer and a baker’s strain) to assess the antifungal activity of three organic plant-based extracts (Hypericum perforatum 10% w/w, Pistacia lentiscus var. Chia 20% w/w and Rosmarinus officinalis 6% w/w). Three different methods were employed (agar disc diffusion, spot assay, and growth curve analysis). Only the Rosmarinus officinalis extract (6% w/w) exhibited inhibitory activity against all the tested yeast strains in the agar disc diffusion method. In the spot assay, all extracts and their carrier oils (sunflower oil and caprylic triglyceride) exerted similar mild antifungal activity. In the growth curve analysis, all extracts significantly lowered the growth rate of the yeasts, but this was not observed for the carrier oils. The results highlighted that it is important to consider more than one method for testing the antimicrobial activity of different compounds. The three yeast strains exhibited differences in their susceptibility to pharmaceutical antifungals, and the beer and baker’s yeasts were resistant to itraconazole. Moreover, polyphenols were detected in all natural extracts which may be linked to their antifungal activity. Our results suggest that we might consider multiple use of these natural extracts in the food industry as food additives or even preservatives to delay food spoilage.

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“…1 H. perforatum is a member of the Hypericum genus, which comprises over 480 species; although native to Europe, North Africa, Western Asia and India, it is now a cosmopolitan species spread throughout the world. 2 Turkey is one of the important centers of the genus with 107 taxa identified, 49 of which are endemic. 3 In our country, H. perforatum is known by names such as "Sarı kantaron, Binbir delik otu, Yara otu, Kan otu, Mayasıl otu, Kuzu kıran".…”

Section: Introductionmentioning

confidence: 99%

Determination of Antimicrobial, Anticarcinogenic Activity of Bioactive Components of Hypericum Perforatum L. Plant

Akkaya,

Çelik,

Ertaş

et al. 2024

International Journal of Chemistry and Technology

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Hypericum perforatum L. (St John's wort), although primarily utilized in traditional medicine, is also frequently employed in modern therapy. Within the scope of the study, H. perforatum was collected from Kahramanmaraş region and dried. Extracts derived from above-ground parts were analyzed to determine their levels of total phenolic and flavonoid compounds, as well as their antioxidant, anticancer and antimicrobial properties. Following the GC-MS analysis of the extracts, a total of 18 distinct fatty acids were identified. The main fatty acid components were identified as behenic (37.90 %), linoleic (21.22 %), gamma-linolenic (15.87 %), oleic (9.45 %) and palmitic acid (7.64 %). The plant extracts were found to have a total phenolic content of 60.22 mg GAE g-1 and a flavonoid content of 7.68 µg QE g-1, as determined through analysis. Additionally, FRAP and IC50 values were determined as 26.96 µg AAE g-1 and 0.44 µg mL-1, respectively. The antimicrobial activities of H. perforatum extracts were investigated among a total of 11 microorganisms, including 9 bacteria and 2 yeasts. It has been observed that extracts possess significant antimicrobial activity against all tested microorganisms. H. perforatum extracts were observed to have dose-dependent inhibition of all organisms. It was observed that H. perforatum extracts killed cancer cells at concentrations of 0.1 mg mL-1 and above on H1299, MCF-7 and HUVEC cancer cell lines.

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The flower of Hypericum perforatum L.: A traditional source of bioactives for new food and pharmaceutical applications

Cited by 12 publications

References 120 publications

Production of Phenylpropanoids, Naphthodianthrones and Antioxidant Status of Hypericum perforatum L. Transgenic Shoots

Production of Phenylpropanoids, Naphthodianthrones and Antioxidant Status of Hypericum perforatum L. Transgenic Shoots

Exploring the Antifungal Activity of Various Natural Extracts in a Sustainable Saccharomyces cerevisiae Model Using Cell Viability, Spot Assay, and Turbidometric Microbial Assays

Determination of Antimicrobial, Anticarcinogenic Activity of Bioactive Components of Hypericum Perforatum L. Plant

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