The FML-vaccine (Leishmune®) against canine visceral leishmaniasis: A transmission blocking vaccine

Saraiva, Elvira M.; Barbosa, André de Figueiredo; Santos, Fernanda Nunes; Borja-Cabrera, G.P.; Nico, Dirlei; Souza, Lucieri O.P.; Mendes-Aguiar, Carolina de O; Souza, Edilma Paraguai de; Fampa, Patrı́cia; Parra, L.E.; Menz, Ingrid; Dias, Jaime Galvão; Oliveira, Sandra Maria de; Palatnik-de-Sousa, Clarisa B.

doi:10.1016/j.vaccine.2005.11.061

Cited by 99 publications

(86 citation statements)

References 38 publications

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“…These antibodies, after ingestion by the vector during the blood meal, are thought to block the parasite fertilization process in the vector by competing with Leishmania to bind to the vector's midgut, with significant results for L. infantum and L. chagasi (Saraiva et al 2006). These findings demonstrated that the vaccine is a potential vector transmission blocker, opening a new perspective for VL control through vector transmission blocking (Dantas-Torres 2006).…”

Section: Insecticidal Plantsmentioning

confidence: 95%

“…Although this measure is focused directly on the canine reservoir, experimental studies have demonstrated that Lu. longipalpis females fed on vaccinated dogs can develop receptors for the antibodies produced by the vaccine antigen fucose-mannose ligand (FML), preventing new forms of Leishmania chagasi ingested by the insect in other blood meals (Saraiva et al 2006). This study was based on previous experiments to produce a "transmission blocker" vaccine against malaria (Arévalo-Herrera & Herrera 2001).…”

Section: Insecticidal Plantsmentioning

confidence: 99%

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Control of phlebotomine (Diptera: Psychodidae) leishmaniasis vectors

Ámora¹,

Beviláqua²,

Feijó³

et al. 2009

Neotrop. entomol.

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Controle de Flebotomíneos (Diptera: Psychodidae) Vetores de Leishmanioses RESUMO -Os fl ebotomíneos são vetores de importância médica e veterinária, podendo transmitir leishmanioses, bartoneloses e algumas arboviroses. A adaptação de algumas espécies a locais que passaram por modifi cações humanas as aproxima dos domicílios, podendo facilitar a transmissão das doenças, e as estratégias adotadas para seu controle têm sido controvertidas. No tocante às leishmanioses, por exemplo, o que sustenta a utilização do controle vetorial e de reservatórios como estratégias de intervenção é a conjectura de que a incidência de infecção em humanos está diretamente relacionada ao número de cães infectantes e a fatores entomológicos. Dessa forma, o controle do vetor pode então oferecer solução menos onerosa e mais prática, o que conduziria a medidas preventivas efi cazes em um maior número de focos de leishmaniose. Não obstante, na complexidade dos fatores envolvidos, o controle químico continua sendo indispensável e o uso de inseticidas biológicos e plantas inseticidas, por exemplo, representam áreas de estudo a serem incentivadas e desenvolvidas, pois apresentam resultados promissores. A análise em questão representa uma oportunidade de avaliação das medidas até então adotadas, principalmente em relação aos métodos e à efi cácia dos componentes entomológicos dos programas de controle das leishmanioses. PALAVRAS-CHAVE: Antropozoonose, Lutzomyia, PhlebotomusABSTRACT -Phlebotomines are of medical and veterinary concern as they vector leishmaniasis, bartonellosis and some arboviruses. The adaptations of some species to places modifi ed by humans bring these vectors into contact with dwellings, which can facilitate disease transmission, and the vector control strategies adopted have rendered controversial results. Regarding leishmaniasis, for instance, which vector and reservoirs control can be effective, there is an assumption that the incidence of human infection is directly related to the number of infectious dogs, as well as to entomological factors. Therefore, vector control can provide a cheaper and more practical solution to prevent cases of leishmaniasis. Nevertheless, due to the complexity of the factors involved, chemical control is still essential, and biological insecticides and insecticide plants, for example, represent areas for study that should be encouraged and developed since they show promising results. This paper summarizes the control strategies adopted so far, especially the methods and effi ciency of the entomological components of leishmaniasis control programs.

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Section: Insecticidal Plantsmentioning

confidence: 95%

Section: Insecticidal Plantsmentioning

confidence: 99%

Control of phlebotomine (Diptera: Psychodidae) leishmaniasis vectors

Ámora¹,

Beviláqua²,

Feijó³

et al. 2009

Neotrop. entomol.

View full text Add to dashboard Cite

show abstract

“…In regard to proteins expressed on the surface of parasites (other than Plasmodium) transmitted to humans by insect vectors (Table 2), only a limited number has been tested as potential TBVs (Tonui et al 2001a;Saraiva et al 2006). …”

Section: Other Pathogen Molecule-based Tbv Candidatesmentioning

confidence: 99%

“…Interestingly, a commercially available treatment for canine visceral leishmaniasis (Leishmune ® ) was recently shown to function as a TBV in sand flies (Saraiva et al 2006). Leishmune ® (FML-vaccine) is a protective vaccine made of L. donovani fucose-manose ligand and the adjuvant saponin, which was successfully tested in a phase III vaccine trial (da Silva et al 2000).…”

Section: Other Pathogen Molecule-based Tbv Candidatesmentioning

confidence: 99%

“…Leishmune ® (FML-vaccine) is a protective vaccine made of L. donovani fucose-manose ligand and the adjuvant saponin, which was successfully tested in a phase III vaccine trial (da Silva et al 2000). Although the surface molecule (FML) was isolated from L. donovani, Leishmune ® exhibited transmission blocking activity in the New World sand fly Lutzomyia longipalpis when infected with Leishmania infantum chagasi (Saraiva et al 2006). Antibodies produced in dogs following Leishmune ® injection reduced Lu.…”

Section: Other Pathogen Molecule-based Tbv Candidatesmentioning

confidence: 99%

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