The folic acid endophenotype and depression in an elderly population

Naumovski, Nenad; Veysey, Martin; Ng, Xiaowei; Boyd, Lyndell; Dufficy, Lisa; Blades, Barbara; Travers, Cheryl; Lewis, Peter; Sturm, Jonathan; Townley-Jones, Maureen; Yates, Zoë; Roach, Paul D.; Lucock, Mark

doi:10.1007/s12603-010-0135-5

Cited by 9 publications

(6 citation statements)

References 26 publications

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“…These findings suggest that cysteinylglycine may have a role in the pathophysiology of CVD and cancer. Recently, it was reported that cysteinylglycine was negatively associated with depression in an elderly population [39]. …”

Section: Discussionmentioning

confidence: 99%

Serum Folate Is Significantly Correlated with Plasma Cysteine Concentrations in Healthy Industry Workers

Mansoor¹,

Hervig²,

Stakkestad³

et al. 2011

Ann Nutr Metab

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Background: A low concentration of serum folate is associated with an increased risk of cardiovascular disease. Extracellular cysteine is involved in aging, cancer and cardiovascular disease. The relationship between serum folate and plasma cysteine is poorly understood. Therefore, we investigated this relationship in industry workers, whose health has economic implications. Methods: The concentration of serum folate was determined by the Access ImmunoAssay System Sanofi Pasteur. Plasma cysteine and homocysteine were measured by an ion-pair HPLC method. The concentrations of serum triglycerides were determined by an enzymatic colorimetric method. Results: We detected a positive correlation between the concentration of serum folate and plasma cysteine, whereas the concentration of serum folate was negatively correlated with plasma homocysteine and serum triglycerides. In a multiple regression analysis with adjustment for age, BMI and smoking, serum folate as the dependent variable exhibited a strong relationship with plasma cysteine, and a negative relationship with plasma homocysteine and serum triglycerides. Conclusion: We observed significant correlations between serum folate, plasma cysteine and serum triglyceride concentrations in industry workers, implying that folate may modulate key aspects of the body’s cysteine and lipid metabolism.

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Section: Discussionmentioning

confidence: 99%

Serum Folate Is Significantly Correlated with Plasma Cysteine Concentrations in Healthy Industry Workers

Mansoor¹,

Hervig²,

Stakkestad³

et al. 2011

Ann Nutr Metab

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“…During the clinical assessment, all participants completed a face-to-face MMSE (41), selfcompleted a Hospital Anxiety and Depression Scale score (HADS) (42), and the neurologist obtained a brief medical history. Written informed consent for participation in this study, from participants that scored less than 24 on MMSE, was obtained by a registered proxy who was assessed as having the necessary cognitive capacity (41).…”

Section: Cognitive Testingmentioning

confidence: 99%

“…All participants completed estimation of daily intake of nutrients during an intervieweradministered validated food frequency questionnaire (FFQ), (23,42,43)…”

Section: Dietary Intake Of B-vitaminsmentioning

confidence: 99%

Relationship Between B-Vitamin Biomarkers and Dietary Intake with Apolipoprotein E є4 in Alzheimer’s Disease

D’Cunha

Georgousopoulou

Boyd

et al. 2019

Journal of Nutrition in Gerontology and Geriatrics

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The potential for B-vitamins to reduce plasma homocysteine (Hcy) and reduce the risk of Alzheimer's disease (AD) has been described previously. However, the role of Apolipoprotein E є4 (APOE4) in this relationship has not been adequately addressed. This case-control study explored APOE4 genotype in an Australian sample of 63 healthy individuals (female=38; age=76.9±4.7y) and 63 individuals with AD (female=35, age=77.1±5.3y). Findings revealed 55 of 126 participants expressed the APOE4 genotype, with 37 of 126 having both AD and the APOE4 genotype. Analysis revealed an increased likelihood of AD when Hcy levels are >11.0µmol/L (p=0.012), Cysteine levels were <255µmol/L (p=0.033) and Serum Folate was <22.0nmol/L (p=0.003; in males only). In females, dietary intake of total folate <336µg/day (p=0.001), natural folate <270µg/day (p=0.011) and vitamin B2 <1.12mg/day (p=0.028) was associated with an increased AD risk. These results support Hcy, Cys, and SF as useful biomarkers for AD, irrespective of APOE4 genotype and as such should be considered as part of screening and managing risk of AD.

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“…[20] The short form of the Arthritis Impact Measurement Scales 2 (AIMS2-SF) questionnaire was also used to evaluate health-related quality of life outcomes in individuals with arthritis as a tool which has been validated in individuals with arthritis and has been used other rheumatic conditions.. [21,22] Food Frequency Questionnaire All participants completed an estimation of daily nutrient intake during an intervieweradministrated validated food frequency questionnaire (FFQ). [23,24] The use of FFQ allowed for consideration of episodic consumption of food items consumed only a few times a year on special occasions such as a religious event, seasonal variations, and the overall variability of day-to-day diets. [25] The FFQ required participants to recall from a list of food items the type and quantity of food consumed over the past year.…”

Section: Measurementsmentioning

confidence: 99%

Assessing the diet quality of individuals with rheumatic conditions: a cross-sectional study

et al. 2020

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Arthritis along with other rheumatic conditions is a significant cause of chronic pain and disability, affecting around 3.5 million Australians. However, little is known regarding the overall diet quality of those living with arthritis. This study aimed to assess the dietary quality of Australians living in the Australian Capital Territory region with rheumatic conditions. This cross-sectional study analysed dietary intake data of individuals living with rheumatic conditions using a validated food frequency questionnaire. Dietary quality was assessed using the Healthy Eating Index-2015 (HEI-2015 to examine associations between diet composition, age, income and arthritis impact using the short form of the Arthritis Impact Measurement Scales 2 (AIMS2-SF). Participants, predominantly female (82.6%), were grouped by age: 18-50 years (n=32), 50-64 years (n=31), and 65+ years (n=23). Significant correlations were observed between age and HEI-2015 (r s =0.337, p=0.002) and income and AIMS2-SF (r s =-0.353, p<0.001). The mean HEI-2015 score for the 18-49 years group was Fair (72.1±12.3), lower than both the 50-64 years group score of Good (81.5±9.72) (p=0.004), and the 65+ years group score of Good (81.8±12.1) (p=0.007). Dietary fibre, seafood and plant protein, fatty acids, and refined grains were identified as dietary components of concern for the 18-49 years group, and total fruit and added sugar were components of concern for people in the worst tertile for the AIMS2-SF. People aged between 18-49 years were consuming a lower quality diet compare to people aged 50 years and over.Further research is needed to understand why this association is occurring in this high socioeconomic region of Australia (a high-income country).

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The folic acid endophenotype and depression in an elderly population

Cited by 9 publications

References 26 publications

Serum Folate Is Significantly Correlated with Plasma Cysteine Concentrations in Healthy Industry Workers

Serum Folate Is Significantly Correlated with Plasma Cysteine Concentrations in Healthy Industry Workers

Relationship Between B-Vitamin Biomarkers and Dietary Intake with Apolipoprotein E є4 in Alzheimer’s Disease

Assessing the diet quality of individuals with rheumatic conditions: a cross-sectional study

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