The Follicle-Stimulating Hormone-Content of the Hypophysis of the Rat as Influenced by Gonadectomy and Oestrogen Treatment

Paesi, F. J. A.; Jongh, S. E. de; Hoogstra, M. J.; Engelbregt, A.

doi:10.1530/acta.0.0190049

Cited by 15 publications

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“…The pituitaries of this age group showed proliferation of heavily granulated PAS positive gonadotrophs. A similar increase in pituitary FSH content was observed by in mice of the Holtzman strain 3 months after ovariectomy, and similar findings have been reported by Paesi, de Jongh, Hoogstra & Engelbregt (1955) in rats. In strain ICRC, on the other hand, a significant decrease in pituitary FSH content was found 15 days after ovariectomy.…”

Section: Discussionsupporting

confidence: 89%

Follicle-Stimulating Hormone Content of the Pituitary Glands of Intact and Ovariectomized Mice of Different Strains

Karande¹,

Sheth²,

Ranadive³

1970

Journal of Endocrinology

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The follicle-stimulating hormone (FSH) content of the pituitaries of intact and ovariectomized mice of the strains C3H/Jax and ICRC, which differ in their adrenocortical responses to ovariectomy was measured at different ages. It was always higher in intact ICRC than that in intact C3H mice, particularly in younger age groups. Ovariectomy caused a fivefold increase in the FSH content in C3H mice after 1 month which was maintained up to 6 months. Thereafter there was a gradual decrease up to 12 months. The increase in pituitary FSH content in ICRC mice after ovariectomy was much less and occurred at a later age. These results agree with cytological observations on the pituitaries of these two strains.

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Section: Discussionsupporting

confidence: 89%

Follicle-Stimulating Hormone Content of the Pituitary Glands of Intact and Ovariectomized Mice of Different Strains

Karande¹,

Sheth²,

Ranadive³

1970

Journal of Endocrinology

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“…Castration of male and female rats, which increases FSH and LH secretion (6), results in altered ratios of hypothalamic content of norepinephrine and dopamine (7). Increased fluorescence of the dopaminergic fibers in the median eminence has been observed in pseudopregnant and lactating rats ( 1 ) .…”

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confidence: 99%

Effect of Dopamine on the Biological Activity and in Vitro Release of ACTH and FSH

Loon

Kragt

1970

Experimental Biology and Medicine

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Considerable evidence is accumulating suggesting that catecholamines play a role in the regulation of anterior pituitary hormone secretion. In addition to the widespread distribution of noradrenergic nerve terminals in the hypothalamus, there is a particularly prominent group of dopaminergic nerve endings in the median eminence ( 1 ) . Stressful stimuli, such as electric shock, hemorrhage, and hypoglycemia which stimulate ACTH secretion, cause a decrease in brain norepinephrine content ( 2), and norepinephrine turnover in hypothalamic nerve terminals is increased under the influence of immobilization stress (3). Furthermore, reserpine, a catecholamine-depleting agent, stimulates ACTH secretion (4), whereas, amphetamine, a catecholamine-releasing agent, inhibits ACTH secretion ( 5 ) .Alterations in hypothalamic catecholamines also appear to be correlated with changes in gonadotropin and prolactin secretion. Increased fluorescence of the dopaminergic fibers in the median eminence has been observed in pseudopregnant and lactating rats ( 1 ) . Castration of male and female rats, which increases FSH and LH secretion (6), results in altered ratios of hypothalamic content of norepinephrine and dopamine (7). Alterations in brain norepinephrine turnover have been reported in castrated male and female rats (8). Finally, drugs such as reserpine and a-methyltyrosine which are known to deplete brain catecholamines (9, 10) have been shown to delay the onset of puberty (1 l ) , inhibit ovulation (12, 13), induce pseu-dopregnancy ( 12), and cause increased prolactin secretion and lactation (14) in the female rat.There are several ways that brain monoamines may affect the secretion of anterior pituitary hormones. Possible mechanisms include serving as transmitters in neural pathways providing input to neurons secreting releasing factors; mediation of presynaptic inhibition on the terminals of such neurons; altering flow in the hypothalamic-hypophyseal portal blood vessels; or direct action on the anterior pituitary cells. This paper reports results of a series of experiments in which the possibility of a direct action of dopamine on the pituitary was tested by incubating anterior pituitary tissue with dopamine in vitro and measuring the amount of ACTH and FSH in the incubation medium.Methods. Anterior pituitary glands were obtained from 200-250 g male Sprague-Dawley rats (Berkeley Pacific Company) that were sacrificed by decapitation. Four halves of hemisected rat anterior pituitaries were preincubated in 2 5-ml Erlenmeyer flasks containing 3 ml of medium 199 for 20-30 min a t pH 7.4 and 37' under constant gassing with 95% 02-5% COz. This preincubation medium was then discarded, replaced by fresh medium, and the incubation was continued for 6 hr under identical conditions.

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“…These four types of cells could be differentiated from each other by the previous mentioned criteria. It (Warwick, 1946;Paesi et al, 1955). It is probable that enhanced uptake of H3-leucine by gonado- trophs of castrated rats would suggest the promoted biosynthesis of the gonadotrophin (FSH, LH).…”

Section: Resultsmentioning

confidence: 99%

EFFECT OF CASTRATION AND ADMINISTRATION OF ESTROGEN ON THE H<SUP>3</SUP>-LEUCINE UPTAKE BY ADENOHYPOPHYSIAL CELLS

Kobayashi

Kigawa

et al. 1967

Endocrinol Japon

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The relative rate of protein(hormone) synthesis by various cell types in anterior pituitary of the female mature rat has been studied by means of autoradiographic technique. Normal, castrated and estrogen-treated castrated rats were injected with tritiated leucine and their pituitaries were removed and pared and autoradiographic grains were counted on the film overlying the cytoplasm of individual cells. Castration promoted the uptake rate of H3ieucine by gonadotrophs, but did not affect the uptake rate of H3-leucine by the other cells. However, the elevated rate of H3-leucine uptake by gonadotrophs of castrated rats was suppressed by estrogen administration.

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The Follicle-Stimulating Hormone-Content of the Hypophysis of the Rat as Influenced by Gonadectomy and Oestrogen Treatment

Cited by 15 publications

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Follicle-Stimulating Hormone Content of the Pituitary Glands of Intact and Ovariectomized Mice of Different Strains

Follicle-Stimulating Hormone Content of the Pituitary Glands of Intact and Ovariectomized Mice of Different Strains

Effect of Dopamine on the Biological Activity and in Vitro Release of ACTH and FSH

EFFECT OF CASTRATION AND ADMINISTRATION OF ESTROGEN ON THE H<SUP>3</SUP>-LEUCINE UPTAKE BY ADENOHYPOPHYSIAL CELLS

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