The food additive E171 and titanium dioxide nanoparticles indirectly alter the homeostasis of human intestinal epithelial cells <i>in vitro</i>

Dorier, Marie; Béal, David; Tisseyre, Céline; Marie-Desvergne, Caroline; Dubosson, Muriel; Barreau, Frédérick; Houdeau, Eric; Herlin‐Boime, Nathalie; Rabilloud, Thierry; Carrière, Marie

doi:10.1039/c8en01188e

Cited by 44 publications

(32 citation statements)

References 61 publications

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“…As there are reports of effects in the liver (Wang et al 2007, Cui et al 2011, Wang et al 2013, Shukla et al 2014, Azim et al 2015, Talamini et al 2019, Cornu, Beduneau, and Martin 2020 and intestine (Urrutia-Ortega et al 2016, Bettini et al 2017, Proquin et al 2018, Dorier et al 2019, Talamini et al 2019 in animal studies, we focused on these organs. With regard to the intestine, animal studies predominantly studied the effects on the colon.…”

Section: Introductionmentioning

confidence: 99%

Possible effects of titanium dioxide particles on human liver, intestinal tissue, spleen and kidney after oral exposure

et al. 2020

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Recent studies reported adverse liver effects and intestinal tumor formation after oral exposure to titanium dioxide (TiO 2). Other oral toxicological studies, however, observed no effects on liver and intestine, despite prolonged exposure and/or high doses. In the present assessment, we aimed to better understand whether TiO 2 can induce such effects at conditions relevant for humans. Therefore, we focused not only on the clinical and histopathological observations, but also used Adverse Outcome Pathways (AOPs) to consider earlier steps (Key Events). In addition, aiming for a more accurate risk assessment, the available information on organ concentrations of Ti (resulting from exposure to TiO 2) from oral animal studies was compared to recently reported concentrations found in human postmortem organs. The overview obtained with the AOP approach indicates that TiO 2 can trigger a number of key events in liver and intestine: Reactive Oxygen Species (ROS) generation, induction of oxidative stress and inflammation. TiO 2 seems to be able to exert these early effects in animal studies at Ti liver concentrations that are only a factor of 30 and 6 times higher than the median and highest liver concentration found in humans, respectively. This confirms earlier conclusions that adverse effects on the liver in humans as a result of (oral) TiO 2 exposure cannot be excluded. Data for comparison with Ti levels in human intestinal tissue, spleen and kidney with effect concentrations were too limited to draw firm conclusions. The Ti levels, though, are similar or higher than those found in liver, suggesting these tissues may be relevant too.

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Section: Introductionmentioning

confidence: 99%

Possible effects of titanium dioxide particles on human liver, intestinal tissue, spleen and kidney after oral exposure

et al. 2020

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“…Brookite has rarely been used or studied thus far, due to its scarcity in the environment (Allen et al, 2010) and difficulties in preparing significant amounts of good quality material (Gong and Selloni, 2007). Both rutile and anatase forms are widely employed in consumer products like toothpaste, sunscreens, food, paints, plastics, paper, and biomedical devices (Wang et al, 2007;Middlemas et al, 2013;de la Calle et al, 2017;Barbosa et al, 2018;Leong and Oh, 2018;Dorier et al, 2019). Furthermore, they are also used in environmental oriented applications including wastewater treatment (Yuzer et al, 2015), air purification (Paz, 2010) and soil remediation (Yang and Xing, 2009).…”

Section: Introductionmentioning

confidence: 99%

Biochemical and histopathological impacts of rutile and anatase (TiO2 forms) in Mytilus galloprovincialis

Leite

Coppola

Monteiro

et al. 2020

Science of The Total Environment

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“…in vitro exposure of bronchial (E. Y. Chen et al, 2011;Kim et al, 2017) and colonic (Dorier et al, 2019) epithelial cell lines to TiO 2 NP stimulated an increase in mucus production. We found a similar increase following a single, high dose of oral TiO 2 NPs in our study.…”

Section: Discussionmentioning

confidence: 94%

Acute high‐dose titanium dioxide nanoparticle exposure alters gastrointestinal homeostasis in mice

Kurtz

Mitchell

Nielsen

et al. 2020

J of Applied Toxicology

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Human exposure to a wide variety of engineered nanoparticles (NPs) is on the rise and use in common food additives increases gastrointestinal (GI) exposure. Host health is intricately linked to the GI microbiome and immune response. Perturbations in the microbiota can affect energy harvest, trigger inflammation and alter the mucosal barrier leading to various disease states such as obesity and inflammatory bowel diseases. We hypothesized that single high‐dose titanium dioxide (TiO2) NP exposure in mice would lead to dysbiosis and stimulate mucus production and local immune populations. Juvenile mice (9‐10 weeks) were gavaged with 1 g/kg TiO2 NPs and examined for changes in mucosa‐associated bacteria abundance, inflammatory cytokines, mucin expression and body mass. Our data provide support that TiO2 NP ingestion alters the GI microbiota and host defenses promoting metabolic disruption and subsequently weight gain in mice.

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The food additive E171 and titanium dioxide nanoparticles indirectly alter the homeostasis of human intestinal epithelial cells in vitro

Abstract: Repeated exposure to E171 or TiO2-NPs, in vitro, induce moderate inflammation and mucus secretion in intestinal cells.

Cited by 44 publications

References 61 publications

Possible effects of titanium dioxide particles on human liver, intestinal tissue, spleen and kidney after oral exposure

Possible effects of titanium dioxide particles on human liver, intestinal tissue, spleen and kidney after oral exposure

Biochemical and histopathological impacts of rutile and anatase (TiO2 forms) in Mytilus galloprovincialis

Acute high‐dose titanium dioxide nanoparticle exposure alters gastrointestinal homeostasis in mice

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