The forgotten art of cold therapeutic properties in cancer: A comprehensive historical guide

The present study examined the effects of the в-adrenergic receptor agonist, isoproterenol, on contractile activity of right ventricle papillary muscles in the rat heart at near-physiological temperature (30°C) and under conditions of deep hypothermia (10°C). Isoproterenol exerts a pronounced positive inotropic effect at 30°C. After agonist addition, the force of contraction increases from 1.2 ± 0.1 mN in control to 2.4 ± 0.4 mN that leads to a reliable acceleration of time parameters of contraction. So, time-to-maximum contraction decreased from 101 ± 6 ms to 85 ± 4 ms; time-to-50% relaxation declined from 55 ± 3 ms to 36 ± 1 ms. Under hypothermic conditions, isoproterenol produced a powerful negative inotropic effect, reducing the force of contraction from 2.2 ± 0.4 mN to 1.2 ± 0.4 mN. Similarly as at 30°C, there was a tendency for increase in contraction speed, so time-to-maximum contraction decreased from 717 ± 52 ms to 624 ± 50 ms, and time-to-50% relaxation was shortened from 667 ± 86 ms to 450 ± 40 ms. Thus, under conditions of deep hypothermia at 10°C, the isoproterenol-induced inotropy changes from positive to negative, while negative lusitropic effect remains clear.

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The forgotten art of cold therapeutic properties in cancer: A comprehensive historical guide

Cited by 4 publications

References 66 publications

Regional Anesthesia with Cryoneurolysis: an Ancient Technique with New Possibilities for Acute Pain

Regional Anesthesia with Cryoneurolysis: an Ancient Technique with New Possibilities for Acute Pain

Deep Hypothermia Inverts the Inotropic Effect of Isoproterenol in the Rat Myocardium

The inversion of the inotropic effect of isoproterenol in the rat myocardium during deep hypothermia

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