2016
DOI: 10.1016/j.cbpa.2016.07.005
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The formate bio-economy

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Cited by 263 publications
(192 citation statements)
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“…Analogous to other ThDP‐dependent enzymes that form similar ThDP carbanion/enamine intermediates, we speculated that 1 can act as nucleophile in a carboligation reaction with an electrophilic carbon center, essentially reversing the native OXC/HACL reactions. This would enable nucleophilic C 1 ‐extension reactions employing formyl‐CoA or oxalyl‐CoA as the donor, which can in turn be produced from the cheap carbon sources formate and oxalate, respectively. Recently, Chou et al.…”
Section: Methodsmentioning
confidence: 99%
“…Analogous to other ThDP‐dependent enzymes that form similar ThDP carbanion/enamine intermediates, we speculated that 1 can act as nucleophile in a carboligation reaction with an electrophilic carbon center, essentially reversing the native OXC/HACL reactions. This would enable nucleophilic C 1 ‐extension reactions employing formyl‐CoA or oxalyl‐CoA as the donor, which can in turn be produced from the cheap carbon sources formate and oxalate, respectively. Recently, Chou et al.…”
Section: Methodsmentioning
confidence: 99%
“…Recently, formate has been applied to support cell growth of E. coli and Saccharomyces cerevisiae , or to provide reducing power for autotrophic growth on CO 2 by engineered E. coli . With FDH* and other NCD‐linked enzymes, it may provide fascinating opportunities to selectively deliver reducing power, together with CO 2 if an NCD‐linked enzyme such as ME* is involved, for valuable metabolite production, which fits well with the idea of the formate bio‐economy . The benefits to use formate in lieu of CO 2 for microbial transformation lie in its better safety, good mass transfer and more importantly, capability of affording a stoichiometric amount of reducing equivalent.…”
Section: Methodsmentioning
confidence: 91%
“…Among the possible reactions, direct hydrogenation of CO 2 to formic acid or the conjugate base formate is of special interest. Formate can serve as substrate for production of other carbon containing products by chemical or biotechnological processes or utilized directly for leather processing, food preservative, or as deicing agent [2, 3]. As substrate for biological fermentations, it overcomes mass transfer limitations of gaseous substrates such as synthesis gas [4].…”
Section: Introductionmentioning
confidence: 99%