The formation and release of aurothioglucose from thioglucose-loaded gold nanoparticles by NIR irradiation: a combined anti-cancer effect of thermotherapy and chemotherapy without the risk of uncontrollable drug burst release and leakage

Lai, Lantao; Bi, Guangming; Sun, Yiwei; Shen, Mingyi; Su, Yubo; Che, Xin; Meng, Dali

doi:10.1039/d1nj04108h

Cited by 2 publications

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“…Herein, we proposed a competitive ABPP strategy (Figure B), including identification experiments and reactivity classification experiments for the target profiles in proteomes of four Au(I) complexes: Auranofin (AF), − Aurothioglucose (ATG), − Aurothiomalate (ATM), − and Aaurothiosulfate (ATS) − (Figure A). Of these Au(I) complexes, AF has been approved by the US Food and Drug Administration for Phase II clinical trial to treat cancer .…”

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Quantitative Chemoproteomic Profiling of Targets of Au(I) Complexes by Competitive Activity-Based Protein Profiling

et al. 2022

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Owing to the encouraging pharmacological action and acceptable toxicity profile, Au(I) complexes have attracted growing interest in the application of disease treatment. In order to investigate their potential target proteins and related bioinformation, herein, we screened four Au(I) complexes and explored the binding proteins utilizing a competitive activity-based protein profiling (ABPP) strategy, including identification experiments and reactivity classification experiments, which offers a simple and robust method to identify the target proteins of Au(I) complexes. We quantified the target proteins of the four Au(I) complexes and found that most of proteins were associated with cancer. In addition, the newly Au(I)-binding proteins and biological gold− protein interaction pathways were exhibited. Furthermore, we estimated the correlation between target proteins of Au(I) complexes and various cancers, which will promote the development of the gold anticancer drugs.

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Quantitative Chemoproteomic Profiling of Targets of Au(I) Complexes by Competitive Activity-Based Protein Profiling

et al. 2022

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The Inhibition Mechanism of Auranofin on Thioredoxin Reductase 1 at the Molecular Level: A New Use of the Old Drug

Wang,

Liu,

et al. 2024

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The formation and release of aurothioglucose from thioglucose-loaded gold nanoparticles by NIR irradiation: a combined anti-cancer effect of thermotherapy and chemotherapy without the risk of uncontrollable drug burst release and leakage

Abstract: Gold nanoparticles (GNPs) have thermotherapy effect on several kinds of solid tumors under the irradiation of near infrared light (NIR).

Cited by 2 publications

References 21 publications

Quantitative Chemoproteomic Profiling of Targets of Au(I) Complexes by Competitive Activity-Based Protein Profiling

Quantitative Chemoproteomic Profiling of Targets of Au(I) Complexes by Competitive Activity-Based Protein Profiling

The Inhibition Mechanism of Auranofin on Thioredoxin Reductase 1 at the Molecular Level: A New Use of the Old Drug

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