The formation of fibers via complementary base pairing of DNA-conjugated bovine serum albumin

Wei, Jing; Sun, Si; Lu, Qian; Gao, Pengcheng; Wang, Yan; Li, Xianhe; Jiang, Yong

doi:10.1016/j.cclet.2017.09.055

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…Supramolecular architectures constructed by the self-assembly of organic molecular building blocks are of great interest owing to their electro-optical properties and potential applications for new discoveries in materials science. − Self-assembly of π-conjugated units holds high utility in the development of supramolecular structures with novel dimensionalities and morphologies. , The highly ordered π-conjugated units are crucial for further applications in areas such as molecular electronics, biomimetic chemistry, and drug delivery systems. − Rod–coil systems are proven to be one of the most promising candidates due to their considerable ability to spontaneously self-organize for the fabrication of various supramolecular nanostructures. − Lee and other research groups systematically investigated a variety of rod–coil molecules, including H-shaped, k-shaped, dumbbell-shaped, and macrocycle rod–coil molecules. − These molecules self-assembled into various well-defined nanoassemblies, including lamellar, columnar, and three-dimensional tetragonal and hexagonal structures in the bulk state, depending on the molecular shape, length of the coil or rod segments, external stimuli, and temperature of the system. Rod–coil molecules with poly(ethylene oxide) (PEO) chains exhibit good solubility and biocompatibility in aqueous solution and facilitate the formation of various supramolecular aggregates with well-defined shapes and sizes, such as micelles, ribbons, planar networks, vesicles, helices, and tubules.…”

Section: Introductionmentioning

confidence: 99%

Morphological Control of Coil–Rod–Coil Molecules Containing m-Terphenyl Group: Construction of Helical Fibers and Helical Nanorings in Aqueous Solution

et al. 2018

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Rod-coil molecules, composed of rigid segments and flexible coil chains, have a strong intrinsic ability to self-assemble into diverse supramolecular nanostructures. Herein, we report the synthesis and the morphological control of a new series of amphiphilic coil-rod-coil molecular isomers 1-2 containing flexible oligoether chains. These molecules are comprised of m-terphenyl and biphenyl groups, along with triple bonds, and possess lateral methyl or butyl groups at the coil or rod segments. The results of this study suggest that the morphology of supramolecular aggregates is significantly influenced by the lateral alkyl groups and by the sequence of the rigid fragments in the bulk and in aqueous solution. The molecules with different coils self-assemble into lamellar or oblique columnar structures in the bulk state. In aqueous solution, molecule 1a, with a lack of lateral groups, self-assembled into large strips of sheets, whereas exquisite nanostructures of helical fibers were obtained from molecule 1b, which incorporated lateral methyl groups between the rod and coil segments. Interestingly, molecule 1c with lateral butyl and methyl groups exhibited a strong self-organizing capacity to form helical nanorings. Nanoribbons, helical fibers, and small nanorings were simultaneously formed from the 2a-2c, which are structural isomers of 1a, 1b, and 1c. Accurate control of these supramolecular nanostructures can be achieved by tuning the synergistic interactions of the noncovalent driving force with hydrophilic-hydrophobic interactions in aqueous solution.

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Section: Introductionmentioning

confidence: 99%

Morphological Control of Coil–Rod–Coil Molecules Containing m-Terphenyl Group: Construction of Helical Fibers and Helical Nanorings in Aqueous Solution

et al. 2018

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Silibinin-Albumin Nanoparticles: Characterization and Biological Evaluation Against Oxidative Stress-Stimulated Neurotoxicity Associated with Alzheimer’s Disease

Pan

Ban

Xu³

2021

j biomed nanotechnol

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Alzheimer’s disease (AD) is strongly associated with oxidative stress which can damage neural cells. Silibinin has shown potential antioxidative effects. However, due to its low solubility in water, silibinin provides low biological activity and bioavailability. Therefore, to increase its pharmacological effects, silibilin was encapsulated into human serum albumin (HSA) nanoparticles and well-characterized by DLS and TEM techniques. The antioxidant activity of silibinin-HSA nanoparticles was evaluated on LPS-induced oxidative stress in neuron-like cells (SH-SY5Y) through MTT, antioxidant activity and apoptotic assay. It was shown that the mean diameter of HSA and silibinin-HSA nanoparticles were 88 and 105 nm, respectively with a drug loading of 24.08%, drug encapsulation rate of 94.72%, and the yield of silibinin-HSA nanoparticles of around 83.41% and the HSA nano-formulation released silibinin for 15 h. The results displayed that cell viability was reduced by LPS (10 μg/mL), who’s also determined to stimulate oxidative stress and apoptosis. However, co-incubation of cells with silibinin (50 μg/mL) or silibinin-HSA nanoparticles led to the recovery of cell viability, activation of SOD and CAT, increase of GSH content, and reduction of ROS level, Caspase-3 activity and fragmentation of DNA. It was also indicated that the neuroprotective and antioxidant activities of silibinin-HAS nanoparticles was greater than free silibinin, indicating that using albumin can be a potential formulation approach for improving the antioxidant efficacy of silibinin.

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The formation of fibers via complementary base pairing of DNA-conjugated bovine serum albumin

Cited by 2 publications

References 22 publications

Morphological Control of Coil–Rod–Coil Molecules Containing m-Terphenyl Group: Construction of Helical Fibers and Helical Nanorings in Aqueous Solution

Morphological Control of Coil–Rod–Coil Molecules Containing m-Terphenyl Group: Construction of Helical Fibers and Helical Nanorings in Aqueous Solution

Silibinin-Albumin Nanoparticles: Characterization and Biological Evaluation Against Oxidative Stress-Stimulated Neurotoxicity Associated with Alzheimer’s Disease

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