The formulation of carvedilol transdermal patch with resin gum as rate control

Abstract

Carvedilol is widely prescribed for long-term hypertension treatment. It is rapidly absorbable by oral administration, but its bioavailability is merely about 20% in humans. Drug delivery is therefore imperative to overcome this weakness. One form of transdermal drug delivery system is a patch. Transdermal patch is composed of various systems, for instance, a reservoir that uses a rate control layer to manage the rate of drug release. This research aimed to observe the effect of using resin gum as the control of drug release rate on the physical characteristics and release of carvedilol in a transdermal patch. The patches were prepared in 5 formulas with different quantities of resin gum, namely 50, 100, 150, 200, and 250 mg. Afterward, they were evaluated physically, and their dissolution and diffusion rates were analyzed. The results showed that resin gum with concentrations of 150 mg and 200 mg was physically qualified for rate control. Besides, the results of dissolution and diffusion tests revealed that transdermal patches with 150 mg of resin gum exhibited the best drug release and penetration.

Formulasi Patch Transdermal Dari Kombucha Teh Hijau Sebagai Antibakteri Staphylococcus aureus

“…Patch merupakan salah satu sediaan transdermal yang berfungsi sebagai sistem penghantaran obat dengan cara ditempel di kulit. Beberapa keunggulan sediaan transdermal ini diantaranya: memberikan efek obat dalam jangka waktu yang lama, pelepasan obat dengan dosis yang konstan, cara penggunaanya mudah, dan dapat mengurangi frekuensi pemberian obat (Kriplani et al, 2018;Yati & Pamungkas, 2018). Dalam sediaan transdermal, patch termasuk ke dalam sistem matrik yang terdiri dari dua komponen utama, yaitu backing layer dan matrik (Chourasia et al, 2019).…”