The four epidemiological stages in the global evolution of inflammatory bowel disease

Kaplan, Gilaad G.; Windsor, Joseph W.

doi:10.1038/s41575-020-00360-x

Cited by 731 publications

(511 citation statements)

References 93 publications

(172 reference statements)

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“…According to previously eminent evidence [20], most of the countries included in our study or/and classi ed by IHME in Asia regions have just experienced two phases of IBD evolution(stages) epidemiological by 2020, emergence and acceleration in incidence (shifting from sporadic cases to markedly increase in the number of new cases). In other words, in Asia, we will confront two additional stages in the evolution of the IBD, compounding prevalence and prevalence equilibrium (increment and drop down in prevalent cases).…”

Section: Discussionmentioning

confidence: 90%

The Emerging Epidemic of Inflammatory Bowel Disease in Asia and Iran by 2035: A Modeling Study

Olfatifar

Zali

Pourhoseingholi

et al. 2021

Preprint

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Background: The projection studies are imperative to optimize the future need for health care systems and proper response to the public health problems such as inflammatory bowel disease (IBD). Methods: To accomplish this, we established an illness-death model based on available data to project the future prevalence of IBD in Asia regions and Iran separately from 2017 to 2035. We applied two deterministic and stochastic approaches. Results: For 2035 compared to 2020, we projected a 2.5-fold increase in prevalent cases for Iran with 69 thousand cases, a 2.3-fold increment for North Africa and the Middle East with 220 thousand cases, quadrupling of the prevalence for India with 2.2 million cases, a 1.5-fold increment for East Asia region with 4.5 million cases and a 1.6-fold increase in prevalence for High‐income Asia‐Pacific and Southeast Asia regions with 183 and 199 thousand cases respectively. Conclusions: Our results showed an emerging epidemic for the prevalence of IBD in Asia regions or/and countries. Hence, we suggest the need for emergency action to control this increasing trend in Asia and Iran.

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Section: Discussionmentioning

confidence: 90%

The Emerging Epidemic of Inflammatory Bowel Disease in Asia and Iran by 2035: A Modeling Study

Olfatifar

Zali

Pourhoseingholi

et al. 2021

Preprint

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“…In western world, it is now in the stage of compounding prevalence, with a stable incidence of 12 to 26 per 100,000 persons, but with a steeply rising prevalence which will be 1% by 2030 in many regions. [ 3 ] Nonalcoholic fatty liver disease (NAFLD) is one of the major metabolic that occur in almost 1 in every 4 people of the world. [ 4 ] Thus, the study on GI field has always been a pivotal part of medicine research.…”

Section: Introductionmentioning

confidence: 99%

Global research status of gastroenterology and hepatology

et al. 2021

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Background: There are no reports on global research status of gastroenterology and hepatology (GI). This study was conducted to reveal the current global research status and trends in GI. Methods: Articles published during 2009 to 2018 in international GI journals were retrieved from the PubMed database. The top 20 countries by output were determined. The gross domestic product (GDP) of each country was also retrieved to figure out the correlation between outputs in GI and economy. The 5 highest-ranking countries were compared in the number of total articles, articles per capita, articles published in top journals, the accumulated impact factor (IF), and average IF. Total articles and articles per capita of the 5 countries were conducted time-trend analysis. The frequently-used terms in titles and abstracts of articles published in 2009 and 2018 were retrieved to conduct co-occurrence analysis to figure out the change of research highlights in GI. Results: A total of 120,267 articles were included, of which 116,485 articles were from 20 highest-output countries. There was a positive correlation between output and GDP ( r = 0.921, P < .001). The USA, Japan, China, Italy, and the UK were the 5 highest-ranking countries. The USA was the largest contributor with 26,215 articles, accounting for 17.4% of the total, but with no significant increasing trend ( P = .122). Other 4 countries all showed increasing trends (all P < .001). For articles per capita, Italy ranked 1st among the 5 countries with 1591.0 articles per 10 million. The USA showed a decreasing trend ( P = .026), other 4 countries all showed increasing trends (all P < .001). The UK had the highest average IF (6.685). For change of research highlights, it is more inclined to research of endoscopy, inflammatory bowel diseases, and nonalcoholic fatty liver disease. Conclusion: It is delightful that the global research output in GI field would be continuingly increased as the major highest-output countries showed increasing trends. However, the developing countries fell behind both in quantity and quality when compared with developed countries.

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“…Epidemiological analyses raise concerns regarding the increased incidence of patients with in ammatory bowel disease (IBD) worldwide; the incidence is estimated to have increased more than 2-fold in selected industrialized countries of the Western world between 2010 and 2030, thus representing global IBD burden 1 . Ulcerative colitis (UC) is an IBD, characterized by in ammation and ulceration of the mucosa limited to the colorectum in patients with repeated relapse and remission; it leads to adverse effects on the quality of life of the patients and the risk of colon cancer 2,3 .…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Colon Crypt Stem Cells in Preserved Epithelial Cell Clumps in Dextran Sulfate Sodium-induced Mouse Model of Ulcerative Colitis

Kobayashi

Yamashita

Ichikawa

et al. 2021

Preprint

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Crypt stem cells rescue the colorectum from refractory ulcers in ulcerative colitis (UC). We previously reported that clumps of a few epithelial cells were scattered in ulcer regions in a dextran sulfate sodium (DSS)-induced mouse model of UC; however, the origin of the clumps is unknown. We determined the immunohistochemical expression of stem-cell markers in the epithelial clumps in female Balb/c mice administered DSS in drinking water for 6 days, followed by withdrawal of DSS for 6 days. Similar to the characteristics of UC, the ulcers were more severe in the distal region close to the anus than in the proximal region of the colorectum. Quantitative analyses revealed that the epithelial clumps appeared in relation to the severity of ulcer, and they expressed the cell adhesion molecules E-cadherin and β-catenin. Among stem cell markers, the epithelial clumps primarily expressed + 5 cell marker Dll1, followed by + 4 cell marker Bmi1 and crypt stem cell marker Lgr5 in that order. Nuclear expression of Sox9, but not Ki-67 and β-catenin was identified in the clumps. The present results suggest that the epithelial clumps comprised crypt-derived stem cells with the potential to regenerate crypts, which could serve as a potential treatment strategy for UC.

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The four epidemiological stages in the global evolution of inflammatory bowel disease

Cited by 731 publications

References 93 publications

The Emerging Epidemic of Inflammatory Bowel Disease in Asia and Iran by 2035: A Modeling Study

The Emerging Epidemic of Inflammatory Bowel Disease in Asia and Iran by 2035: A Modeling Study

Global research status of gastroenterology and hepatology

Characteristics of Colon Crypt Stem Cells in Preserved Epithelial Cell Clumps in Dextran Sulfate Sodium-induced Mouse Model of Ulcerative Colitis

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