The Fourth Bioelectronic Medicine Summit “Technology Targeting Molecular Mechanisms”: current progress, challenges, and charting the future

Abstract

There is a broad and growing interest in Bioelectronic Medicine, a dynamic field that continues to generate new approaches in disease treatment. The fourth bioelectronic medicine summit “Technology targeting molecular mechanisms” took place on September 23 and 24, 2020. This virtual meeting was hosted by the Feinstein Institutes for Medical Research, Northwell Health. The summit called international attention to Bioelectronic Medicine as a platform for new developments in science, technology, and healthcare. The meeting was an arena for exchanging new ideas and seeding potential collaborations involving teams in academia and industry. The summit provided a forum for leaders in the field to discuss current progress, challenges, and future developments in Bioelectronic Medicine. The main topics discussed at the summit are outlined here.

Bioelectronic Medicine for Sports: Justification of Biophysical Mechanisms and Clinical F Easibility of Use

“…Біоелектронна медицина -це результат новаторських відкриттів механізмів нейронного контролю біологічних процесів, які становлять патогенез захворювань, і навіть розроблення пристроїв для модуляції цих специфічних нейронних ланцюгів задля терапії за допомогою електронів замість ліків. Біоелектронна медицина знаходиться на передньому краї потенційної революції у лікуванні захворювань та є перспективним напрямом для наукових досліджень (Datta-Chaudhuri, et al, 2021;Ezeokafor, et al, 2021;Ganzer, Sharma, 2019;Gibney, et al, 2021;Olofsson, et al, 2017;Sanjuan-Alberte, et al, 2018;Singh, et al, 2022;Sevcencu, 2022).…”

Development of polarization-sensitive optical coherence tomography imaging platform and metrics to quantify electrostimulation-induced peripheral nerve injury in vivo in a small animal model

“…Therapeutic electrical neuromodulation devices are under active development for the treatment of numerous diseases and conditions, 1 , 2 including epilepsy, depression, digestion/bowel function, hunger regulation, 3 – 6 rheumatoid arthritis, and Crohn’s disease. 7 , 8 However, electrode implantation, unsafe stimulus parameters, prolonged application of electrical stimulation, or constriction of local nerve blood flow, can all potentially damage the nerve, cause loss of function, or result in reduced treatment effectiveness. 9 , 10 Disease states further complicate assessment of neural activity and behavior, as many pathways are not fully understood, even under healthy conditions.…”

Bioelectronic Medicine for Sports: Justification of Biophysical Mechanisms and Clinical Feasibility of Use

“…Bioelectronic medicine is the result of pioneering discoveries of mechanisms for neural control of biological processes that underlie disease, and the development of devices to modulate these specific neural circuits as therapy using electrons instead of drugs. Bioelectronic medicine is at the forefront of a potential revolution in the treatment of diseases and is a promising area of scientific research (Datta-Chaudhuri et al, 2021;Ezeokafor et al, 2021;Ganzer, Sharma, 2019;Gibney et al, 2021;Olofsson et al, 2017;Sanjuan-Alberte et al, 2018;Singh et al, 2022;Sevcencu, 2022). This is all so, because the science of the 21 st century has advanced significantly and crossed the global rubicon understanding the microlevel organization of substance.…”