The past 10 years have seen a resurgence in studies of the Milky Way's interstellar medium (ISM) driven by new surveys of the Galactic plane at wavelengths from 4 microns to 20 cm. These surveys, which include the H I International Galactic Plane Survey, the Spitzer GLIMPSE and MIPSGAL surveys, the recently commenced Herschel HI-GAL survey, and several surveys of CO J = 1-0, are allowing us to trace the evolution of the ISM on scales of parsecs and sub-parsecs from warm and diffuse through to cold, dusty molecular gas. Together with hydrodynamical simulations of ever-increasing sophistication our understanding of the ISM in the disk of the Milky Way has evolved from the 1970's simplistic models of cold clouds surrounded by warm gas to a complex mixture of phases intertwined and interconnected, whose cooling is driven by colliding flows. Here I focus on the "frothy" ISM, where structure and evolution is impacted by bubbles, shells and supershells. I discuss the role of these objects in cooling, the formation of molecules and even the transfer of matter out of the disk of the Galaxy.