The Framingham School Nevus Study

Oliveria, Susan A.; Geller, Alan C.; Dusza, Stephen W.; Marghoob, Ashfaq A.; Sachs, Dana L.; Weinstock, Martin A.; Buckminster, Marcia; Halpern, Allan C.

doi:10.1001/archderm.140.5.545

Cited by 56 publications

(75 citation statements)

References 37 publications

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“…Zalaudek et al [7] found that the predominance of dermoscopic types of melanocytic nevi varies according to individual’s age, and that there is a predominance of the globular pattern in children, the latter being consistent with a previous study [20]. However, there are no studies defining the most characteristic patterns in children of our population and relating particular pattern predominance with constitutional and environmental factors.…”

Section: Introductionsupporting

confidence: 84%

“…Our aims were to investigate the number and dermoscopic patterns of melanocytic nevi among Spanish children, and to assess constitutional and environmental factors associated with the number of nevi and the dermoscopic pattern. Interestingly, there are only 2 reports in the literature regarding dermoscopic pattern prevalence in children [7, 20], and no assessment of the association of constitutional and environmental factors and dermoscopic patterns has been conducted.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence Study of Nevi in Children from Barcelona

et al. 2008

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Background: Malignant melanoma is becoming an increasingly important problem in public health as incidence rates have been increasing continuously in Caucasian populations. Childhood and adolscence is an important time of life for the formation and evolution of nevi, and the presence of a higher number of nevi in early life could predict a major risk of developing melanoma. Objectives: (1) To determine the number of nevi and the dermoscopic pattern predominance in children of our population. (2) To relate it to constitutional and environmental factors. Methods: Clinical and dermoscopic examinations were performed in 180 children aged 1–15 years. A questionnaire including topics such as past history of sunburns, tanning ability, tendency to sunburn, history of sunlight exposure, use of sunscreens, tendency to freckle and family history of cancer was completed in a face-to-face interview with the parents. On clinical examination, we evaluated hair color, eye color, number of nevi and the presence of nevi in specific locations. All melanocytic lesions were examined dermoscopically, and all patterns were registered as present or absent. We also registered the predominant dermoscopic pattern of the child, defined as being present in more than 40% of all of the individual’s nevi. Results: The mean number of moles was 17.5. Male gender, past history of sunburns, facial freckling and family history of breast cancer were independent risk factors for having a higher number of nevi. We found that 61.1% of children had nevi on the face and neck, 17.2% on the buttocks, 11.7% on the scalp, 19.4% had acral nevi and 31.7% had congenital nevi. We found the presence of nevi in some of these locations to be a risk factor for having a higher number of nevi. The most frequent dominant dermoscopic pattern found in our population was the globular type. Interestingly, we found that the homogeneous pattern predominates in the youngest children, the reticular pattern predominates in adolescents and the dominant globular pattern is constant among all ages evaluated. Conclusion: This is the first study clinically and dermoscopically characterizing nevi in children from our population, and evaluating constitutional and environmental risk factors.

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Section: Introductionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Prevalence Study of Nevi in Children from Barcelona

et al. 2008

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“…Preliminary findings using these data were published as an ancillary analysis in a prior study [28]. In this initial study, dermoscopic changes were noted in 10% (n = 5/50) of the study population at 1-year follow-up.…”

Section: Resultsmentioning

confidence: 83%

“…The methods have been described in detail [28]. Briefly, skin examinations and photography of back nevi were performed and follow-up skin examinations and photography were conducted 1 year later.…”

Section: Methodsmentioning

confidence: 99%

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Clinical and Dermoscopic Changes in Common Melanocytic Nevi in School Children: The Framingham School Nevus Study

LaVigne

Oliveria²,

Dusza³

et al. 2005

Dermatology

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Background: Nevi are potential precursors of malignant melanoma and are important risk factors for the development of the disease. Childhood may be a critical time for the formation and evolution of nevi. Objectives: To document the development of new nevi and to document the clinical and dermoscopic changes in index nevi in school children during a 1-year follow-up. Methods: Digital photographs and dermoscopic images of the back of subjects were compared at baseline and 1-year follow-up to assess changes in nevi counts and in clinical and dermoscopic features of index nevi. Results: Overall participation rate was 81% (42/52). 56.4% of study participants were found to have an increased number of nevi at 1-year follow-up. All nevi were small and clinically insignificant. Fifty percent of study participants were found to have dermoscopic changes in their index nevi at 1-year follow-up. Eighty-five percent of these changes were classified as subtle and 15.0% as obvious. Conclusions: A significant portion of students developed new nevi over the course of 1 year. Most index nevi remained stable in pattern and structure. Benign dermoscopic changes occurred in 50.0% of index nevi. However, none of the dermoscopically changed nevi revealed any major changes and the overall nevus pattern remained unchanged. The relevance of these changes is uncertain and further follow-up may elucidate their significance.

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